A.G. Scientific, Inc. Datasheets for Biological Materials
Biological materials are biocompatible materials, natural or man-made, that comprise a whole or a part of a living structure or biomedical device that performs, augments, or replaces a natural function
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| Product Name | Notes |
|---|---|
| (Synthetic) Prenylated flavonoid. Phytoestrogen. Induces apoptosis in mature adipocytes. | |
| ** Inquire for product availability ** | |
| *USE W-1028* Anti-cancer antibiotic that binds tightly to DNA. Appears to overcome MRP-mediated multidrug resistance. | |
| 3,3',5,5'-Tetramethy lbenzidine (TMB) has been shown to be a safe, sensitive substrate for the assay of horseradish peroxidase (HRP). Initially, in the presence of HRP and hydrogen peroxide, a one-electron... | |
| 3,3'5,5'-Tetramethyl benzidine (TMB) has been shown to be a safe-sensitive substrate for the assay of horseradish peroxidase (HRP). Initially, in the presence of HRP and hydrogen peroxide, a one-electron oxidation... | |
| 5-Methylcytidine | |
| A 1 M solution of Tris HCl in water (pH 6.8) | |
| A 10% soultion of NP-40 in water. | |
| A bisphosphonate compound that inhibits bone resorption, the natural, ongoing process of bone being destroyed by osteoclasts. Also inhibits farnesyl diphosphate synthase (IC50 = 200 nM). | |
| A broad spectrum matrix metalloprotease (MMP) inhibitor with IC50 values of 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively. It covalently binds to... | |
| A cell permeable bis(1H-2-indolyl)-1- methanone compound that acts as a highly selective, ATP-competitive and reversible inhibitor of platelet-derived growth factor receptor tyrosine kinase. Also potently inhibits Flt3 activity. Sensitzes 32D... | |
| A cell permeable general inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM),... | |
| A cell-permeable indoly-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promotin sbunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 μM). | |
| A cell-permeable piperazinyl-quinazol ine carboxamide compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of PDGF receptor family of tyrosine kinases. Affects the activities of other kinases only... | |
| A cell-permeable purine compound that induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells (ECâ‚…â‚€ = 1 μM) and in MC3T3-E1 lineage-committed preosteoblasts. Also shown to induce transdifferentiation in pre-adipocytes... | |
| A cell-permeable purine derivative that acts as an antagonist of aryl hydrocarbon receptor and promotes the self-renewal of hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a... | |
| A cell-permeable quinolinyl-thiourea compound that acts as a potent, ATP-competitive, and reversivle inhibitor of PDGFR. Inhibits c-kit receptor only at much highter concentrations. Shown to potently inhibit neointima formation in... | |
| A cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR. The IC50 values are 2, 8, 20, 26, 48, 83, 88, 150... | |
| A cell-permeable, potent, and selective human A3 adenosine receptor antagonist (K1 = 0.66 μM) and an aurora kinase inhibitor (IC50's of 30-550 nM for blast colony formation assay). Induces dedifferentiation... | |
| A cell-permeable, reversible and selective inhibitor of the deubiquitinating activity of human USP14 (IC50 = 4-5 μM). IU1 promotes cell survival during proteotoxic stress and selectively stimulates ubiquitin-dependent protein degradation... | |
| A cell-permeable, reversible, and selective Rac1 inhibitor; inhibiting Rac1 activation by the Rac-specific guanine nucleotide exchange factors (GEFs) TrioN an Tiam 1 without affecting the closely related GTPases, Cdc42, and... | |
| A cocktail of five phosphatase inhibitors which has been optimized for the inhibition of protein tyrosine phosphatases, acid and alkaline phosphatases. Recommended for use with tissue and cell extracts including... | |
| A cocktail of five protease inhibitors which has been optimized for the inhibition of a broad range of proteases and esterases. 1X stock solution contains 500 μM AEBSF. HCl, 150... | |
| A cocktail of five protease inhibitors which has been optimized for the inhibition of a broad range of proteases and esterases. A 1x stock solution contains 500uM AEBSF.HCl, 150nM Aprotinin,... | |
| A cocktail of four phosphatase inhibitors which has been optimized for the inhibition of both serine/threonine and protein tyrosine phosphatases. Reconstitute each vial with 1 ml H2O to obtain a... | |
| A cocktail of four protease inhibitors which has been optimized for the inhibition of a broad range of serine proteases. 1X stock solution contains 500 μM AEBSF. HCl, 420 nM... | |
| A cocktail of four protease inhibitors which has been optimized for the inhibition of serine, cysteine but not metalloproteases. Reconstitute each vial with 1 ml H2O to obtain a 100X... | |
| A competitive cytidine deaminase inhibitor and multidrug resistance modulator. Makes tumor cells more sensitive to radiation therapy making it useful for cancer treatment | |
| A component of the oligomycin complex (O-1060). Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F1F0), preventing phosphoryl group transfer. Induces apoptosis. Bulk pricing available, inquire for more details. | |
| A component of the oligomycin complex (O-1060). Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F1F0), preventing phosphoryl group transfer. Induces apoptosis. Bulk available, inquire for pricing details. | |
| A constituent of the pepper Piper longum L. that selectively kills cancer cells but not normal cells. Piperlongumine increases the level of reactive oxygen species (ROS) and apoptotic cell death... | |
| A convenient set consisting of eight inhibitors useful for studying JAK/STAT signaling pathway. The inhibitors are: 5 mg of AG 490 (Cat. No. 1570-5), 5 mg of CP-690550 (Cat. No. | |
| A convenient set consisting of eleven inhibitors useful for the study of PI3-K/Akt/mTOR pathway. The 11 inhibitors are: 1 mg of Akt Inhibitor, Isozyme-selective (Cat. No. 1708-1), 5 mg of... | |
| A convenient set consisting of fourteen inhibitors useful for the study of EGFR signaling pathway. The fouteen inhibitors are: 5 mg of AG 490 (Cat. No. 1570-5), 1 mg of... | |
| A convenient set consisting of seven inhibitors useful for the study of MAP Kinase signaling pathway. The seven inhibitors are: 1 mg of PD 184352 (Cat. No. 1585-1), 5 mg... | |
| A convenient set of eight small molecule modulators useful in stem cell research. The eight modulators are: 5 mg of BIX01294, 5 mg of CHIR99021, 5 mg of PD 184352,... | |
| A convenient set of five small molecules useful for generating human induced pluripotent stem cells (iPSC) from primary cells. The five products are: 1 mg of A-83-01, 2 mg of... | |
| A convenient set of five small molecules useful for self-renewal in stem cells and induced pluripotent stem cells (iPSCs). The five products are: 1 mg of A-83-01, 5 mg of... | |
| A convenient set of three inhibitors useful for sustaining embryonic stem (ES) cell self-renewal. The three inhibitors are: 5 mg of CHI99021, 5 mg of PD 184352, and 500 μg... | |
| A convenient set of three small molecules useful for promoting the transformation of fibroblasts into stem cells. The three products are: 2 mg of PD 0325901, 1 mg of SB-431542,... | |
| A convenient, sterile-filtered cocktail solution (1000X, in DMSO) containing four signaling inhibitors YPAC (Y-27632, a ROCK inhibitor, 10.0 mM; PD0325901, a MEK Inhibitor,1.0 mM; A83-01, a ALK5 inhibitor, 0.5 mM; | |
| A convenient, sterile-filtered cocktail solution (1000X, in DMSO) containing four small molecules useful for enhancing the reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs). The four... | |
| A custom concentration cocktail for optimum inhibition of calcium-dependent endopeptidases, trypsin-like serine proteases, papain, and cysteine proteases, Contains2mg/ml antipain, 0.5mg mg/ml leupeptin; 50 mg/ml EDTA in water. | |
| A custom concentration cocktail for optimum inhibition of calcium-dependent endopeptidases, trypsin-like serine proteases, papain, and cysteine proteases. CONTAINS: 0.2mg/ml antipain; 0.05mg/ml leupeptin; 50mg/ml EDTA in water. | |
| A direct activator of soluble Guanylyl Cyclase (sGC), independent of Nitric Oxide. | |
| A DNA methyltransferase (DNMT) inhibitor. RG-108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences. In combination with BIX 01294... | |
| A donor of superoxide and nitric oxide, which spontaneously forms peroxynitrite. Useful in free radical research. NOTE: 10mg & 50mg in limited supply, inquire for availability. | |
| A fungal metabolite that causes an increase in endoplasmic reticulum ATP-dependent calcium pump activity. | |
| A fungal metabolite that specifically inhibits phosphatidylinositol 3-kinase (PI-3), mitogen-activated protein kinase (MAPK) and myosin light-chain kinase (MLCK). Seeking published researchers utilizing our Wortmannin product? Hit the hot link for... | |
| A glycopeptide antibiotic used in the diagnosis of the bleeding disorder, von Willebrand's disease (VWD). Ristocetin CoFactor Activity Assay is used to diagnose VWD while the Ristocetin Induced Platelet Agglutination... | |
| A glycylglycine type of antibiotic derived from tetracycline. Inhibits protein translation in bacteria by binding to the 30S ribosomal subunit and blocking entry of amino-acyl tRNA molecules into the A... | |
| A highly potent ATP-noncompetitive MEK inhibitor. It inhibits MEK with an in vitro IC50 of 1-1.3 nM. It does not inhibit other kinases. Highly recommended tool to inhibit MKK1 or... | |
| A highly potent, selective and irreversible thrombin inhibitor. | |
| A highly selective inhibitor of inducible Nitric Oxide Synthase (iNOS). | |
| A highly selective non-ATP competitive allosteric Akt inhibitor with IC50's of 8 nM, 2 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. MK-2206 potently inhibits phosphorylation of Thr³â°â¸ | |
| A Hsp90 inhibitor. NVP-AUY922 has excellent potency against Hsp90 in a fluorescence polarization binding assay with an IC50 of 21 nmol/L against the β-isoform and of 13 nmol/L for the... | |
| A member of the ecdysteroid family, which are involved in basic invertebrates functions, such as molting, metamorphosis, reproduction, metabolism and excretion. | |
| A microtubule-binding molecule that induces reversible fission of multinucleated myotubules into mononucleated fragments. Induces changes in the expression levels of genes implicated in extracellular matrix remodeling, inflammation, coagulation, signal transduction,... | |
| A naturally occurring flavonoid that shows anti-complement, anti-inflammatory and free radical scavenger activity. Inhibits the production of the inflammatory mediators nitric oxide (NO), TNF-α and IL-12 in activated macrophages. Also... | |
| A necroptosis inhibitor. The biological activity of necrostatin-7 (Nec 7) is different from that of necrostatin 1 to necrostatin 5 as Nec 7 does not inhibit RIP1 kinase. Nec-7 may... | |
| A negative control for the Src family kinase inhibitor PP2 (Cat. No. 1767-1,5). Inhibits the activity of EGFR kinase at an IC50 = 2.7 μM. | |
| A Nitric Oxide Donor, useful for reliable generation of Nitric Oxide (NO) in vitro or in vivo. Half Life (t1/2) for NO release at 37°C is 39 minutes. | |
| A novel small molecule that helps in promoting human embyronic stem cell (hESC) survival by > 30-fold. The dramatic increase in cell survial has been attributed to the protection of... | |
| A p38 MAP kinase inhibitor. VX-702 dose-dependently inhibited the production of IL-6, IL-1β and TNFα (IC50 = 59, 122 and 99 ng/ml, respectively). Pre-incubation of platelets with VX-702 (1 μM)... | |
| A phytotoxic cycli tetrapeptide which is an inhibitor of chloroplast F1-ATPase (CF1). Inquire for bulk & other package size pricing. | |
| A plant-derived flavanoid. Cell-permeable. Inhibits PIM1 kinase (IC50 = 1.1 μM), PI 3-Kinase (IC50 = 3.8 μM) and phospholipase A2 (IC50 = 2 μM). Also acts as an anti-tumor agent; | |
| A potent (Ki = 0.6 nM), specific and reversible proteasome inhibitor. It inhibits cell proliferation of H460 cells (Human non-small cell lung cancer cell lines) with an IC50 of 0.1... | |
| A potent and selective ALK (anaplastic lymphoma kinase) inhibitor that blocked the growth of ALCL (anaplastic large cell lymphoma)-derived and ALK-dependent cell lines with IC50 = 2-10 nM. NVP-TAE684 treatment... | |
| A potent and selective FGFR1 tyrosine kinase inhibitor (IC50 = 21.5 nM). Blocking of the FGFR signaling pathway by PD 173074 leads to self-renewal of stem cells via ERK1/2 activation. | |
| A potent and selective in vitro mTOR inhibitor that targets the ATP domain of mTOR (IC50 = 8 nM). Inhibits other PI 3-Kinases only at much higher concentrations. Recently it... | |
| A potent and selective inhibitor (IC50 = 700 nM) of vascular endothelial growth factor receptor 2 (VEGFR 2) (also known as Flk1). Very weak inhibitor of PDGFR-kinase (IC50 >50 μM),... | |
| A potent and selective inhibitor of fibroblast growth factor receptor (FGFR) (IC50 = 0.03 μM for FGFR1) and vascular endothelial growth factor receptors (VEGFR) (IC50 = 0.02 μM for VEGFR2). | |
| A potent and selective inhibitor of Ras farnesyltransferase. Inquire for other sizes/ bulk. | |
| A potent and selective inhibitor of the TGF-β 1 receptor ALK5 (IC50 = 94 nM). It inhibits ALK4 only at higher concentrations (IC50 = 140 nM). Suppresses renewal in embryonic... | |
| A potent and selective protein kinase C inhibitor (ICâ‚…â‚€=15nM for rat brain PKC). | |
| A potent and specific inhibitor of the protein kinase c-Raf (ICâ‚…â‚€ = 70 nM). Inhibits c-Raf with ten-fold increased potency compared to B-Raf, but does not inhibit many other protein... | |
| A potent inhibitor of kinase insert domain-containing receptor [KDR/vascular endothelial growth factor receptor (VEGFR) 2] tyrosine kinase activity (IC50 = 40 nM). This compound also inhibits fms-like tyrosine kinase 4... | |
| A potent inhibitor of Neuronal and Inducible Nitric Oxide Synthase. | |
| A potent inhibitor of sirtuin 2 (SIRT2) (IC50 = 3.5 μM). AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRt3. Inhibition of SIRT2 rescued α-synuclein toxicity and modified... | |
| A potent inhibitor of Src-family protein tyrosine kinases. Inquire for more details, pricing & lead time. | |
| A potent inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; ICâ‚…â‚€=0.69 nM). Also inhibits the growth of primary human tumor cell cultures. | |
| A potent mTOR (mammalian target of rapamycin) inhibitor (IC50 = ~10 nM for mTORC1 and mTORC2, respectively). Displays no activity against PI 3-kinase or 76 other kinases tested. | |
| A potent, cell-permeable and ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3) (Ki= 9 nM for GSK-3α). Has little activity against 24 other protein kinases (IC50 > 10 μM). Stimulates glycogen... | |
| A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-k inase pathways. It is significantly more potent and active... | |
| A potent, cell-permeable reversible, and selective inhibitor of EGF receptor (EGFR)tyrosine kinase activity (ICâ‚…â‚€=0.45 nM). The reversible nature of this compound makes it a less effective antitumor agent than PD... | |
| A potent, cell-permeable, irreversible, and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (ICâ‚…â‚€=0.70 nM. Does not inhibit other protein kinases. Acts by binding to the catalytic domain of... | |
| A potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO; IC50 = 300 nM). Does not affect catalase or glutathione peroxidase activities. Also displays no effect on... | |
| A potent, selective inhibitor of neuronal Nitric Oxide Synthase. | |
| A potent, selective inhibitor of Nitric Oxide sensitive Guanylyl Cyclase (IC50=20 nm). Solutions may slowly decompose. | |
| A pyridinyl imidazole which acts as a specific inhibitor of p38 MAP Kinase. Does not inhibit the MAP kinase homologs JNK and p42 MAP kinase. | |
| A ready-to-use buffer useful for lysing cells and tissues for radioimmunoprecipita tion assay. RIPA buffer also results in low background in immunoprecipitation/ pull down assays. The buffer (1X) contains 150... | |
| A selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC50 =0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell... | |
| A selective ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in humans. Displays antitumor and antiviral properties. Stimulates antibody secretion, cytokine production, protection from apoptosis... | |
| A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes... | |
| A small-molecule chemical inhibitor of Sonic hedgehog (Shh) signaling, that blocks hedgehog signaling through specific binding and blockade of Shh signaling factor. It is the first characterized hedgehog inhibitor whose... | |
| A specially formulated cocktail of five protease inhibitors with broad specificity for the inhibition of aspartic, cysteine, serine, and metalloproteases, as well as aminopeptidases. Recommended for use with bacterial cell... | |
| A specially formulated cocktail of four protease inhibitors with broad specificity for the inhibition of serine, cysteine, aspartic and metallo-proteases. Recommended for use with fungal and yeast extracts. 1 ml... | |
| A specially formulated cocktail of six protease inhibitors with broad specificity for the inhibition of aspartic, cysteine and serine proteases as well as aminopeptidases. 1ml is recommended for the inhibition... | |
| A specially formulated cocktail of six protease inhibitors with broad specificity for the inhibition of aspartic, cysteine and serine proteases as well as aminopeptidases. When reconstituted to 1 ml, each... | |
| A specially formulated cocktail of six protease inhibitors with broad specificity for the inhibition of serine, cysteine, aminopeptidases, and metalloproteases. Reconstitute with 100ml H20 to obtain 100ml cocktail solution. The... | |
| A specially formulated cocktail of three phosphatase inhibitors that will inhibit alkaline phosphatases and serine/threonine protein phosphatases such as PP1 and PP2A. Recommended for use with tissue and cell extracts,... | |
| A specially formulated cocktail of three phosphatase inhibitors that will inhibit both serine/threonine and alkaline phosphatases. Liquid. In 1 ml DMSO. Each vial contains 2.5 mM (-)-p-Bromotetramiso le oxalate, 500... | |
| A specially formulated cocktail of three protease inhibitors with selective specificity for the inhibition of cysteine proteases, including calpains, cathepsins and papain. Liquid. In 1 ml DMSO. Each vial contains... | |
| A specific, ATP-competitive small molecule inhibitor of the catalytic activity of Met. Displays selectivity for Met enzyme versus a panel of other tyrosine kinases with the following IC50 values: Met... | |
| A Stat3 phosphorylation inhibitor. LLL12 inhibits STAT3 phosphorylation (Tyr705) and STAT3 activities and down-regulates STAT3 downstream targets; inhibits proliferation, colony formation, and cell migration and induces apoptosis in various human... | |
| A STAT3 signaling pathway inhibitor. Niclosamide potently inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively... | |
| A substrate of PI3-Kinase II & III, used for high-throughput screening. Synthetic, free acid. Refer to P1557 for PI(3) diC16 | |
| A synthetic peptide that irreversibly inhibits activity of caspase-2. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro... | |
| A synthetic peptide that irreversibly inhibits activity of LEVD-dependent caspases (e.g., caspase-4). The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for... | |
| A synthetic peptide that is cell permeable, nontoxic and used as a negative control to the caspase inhibitor Q-VD-OPH, the new generation of caspase inhibitor. It is stable in aqueous... | |
| A synthetic peptide that is potent, cell permeable, nontoxic and irreversibly inhibits caspase activity to blocks apoptosis. The new generation of caspase inhibitor is more stable in aqueous environment and... | |
| A synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs. Pam3CSK4 is a potent activator of the proinflammatory transcription factor NF-kB. Activation is mediated by the... | |
| A Tankyrase (TNKS) inhibitor (IC50 = 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of... | |
| A terpenoid lactone derived from Azadirachta indica (Neem tree) that displays a variety of biological activities including anti-malarial and anticancer activity. Recently it has also been shown that nimbolide sensitizes... | |
| A useful tool for elucidating melanocyte stem cell regeneration, recruitment and maintenance mechanisms. Specifically ablates zebrafish larval melanocytes or melanoblasts, and this melanocytotoxicity is dependent on tyrosinase activity. | |
| A vanadium complex that acts as a highly potent and specific inhibitor of Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN). | |
| A water soluble form of the potent p38 (SAPK2a) inhibitor SB202190. | |
| A water-soluble diester prodrug of the active ingredient Tenofovir, that belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (NtRTIs), which block reverse transcriptase, an... | |
| A widely utilized inhibitor of Nitric Oxide Synthase (NOS). | |
| Activity: >40 units/mg powder. One unit is defined as amount of enzyme required to generate 1umol of H202 per minute at 37C, pH 6.5. Contaminate info: Glutamate oxalacetate transaminase (GOT)... | |
| Acts as a general metalloprotease inhibitor. Chelates iron, zinc and other divalent metals. Forms a red chelate with Fe2+ that absorbs maximally at 510 nm and can be used as... | |
| Acts as a potent inhibitor of glutamate carboxypeptidase II (NAAG peptidase) and an mGluR3-selective agonist. | |
| All-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase. | |
| An allosteric phosphoinositide-dep endent protein kinase-1 (PDK1) activator (Kd =10.3 μM). Binds exlusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site. It has recently been found... | |
| An analog of Mitoxantrone (Cat. No. 1885-50, 250) that displays antitumor properties with fewer toxic effects on cardiac tissue. Acts as a topoisomerase II poison and intercalating agent. | |
| An analog of polyunsaturated fatty acid. A potent vasodilator. | |
| An anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release , stimulates the insulin... | |
| An anti-diabetic agent. It reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of... | |
| An anti-diabetic drug of the biguanide class. Increases AMPK activity without increasing AMP/ATP. Also acts as a mitochondrial complex I inhibitor. | |
| An anti-tumor antibiotic and type II topoisomerase inhibitor. It disrupts DNA synthesis and DNA repair in both healthy and cancer cells. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of... | |
| An antidiabetic thiazolidinedione (TDZ) drug with anti-inflammatory and anti-tumor activities. A potent and selective PPARÉ£ agonist. The EC50 values for transactivation of human and murine PPARÉ£ in a cell-based assay... | |
| An antioxidant and an inhibitor of NF-kB; prevents induction of nitric oxide synthase (NOS) by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis... | |
| An extremely potent and specific inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 25 pM). Inhibits other purified kinases only at micromolar or higher concentrations. | |
| An immunosuppressant and a potent inhibitor of NF-κB activation in T cells, with an almost complete inhibition at 200 nM. Suppresses cytokine production (IFN-γ, TNF-α, IL-2 and IL-4) and inhibits... | |
| An indolocarbazole derivative with antineoplastic properties. Acts as a potent inhibitor of several tyrosine kinases including FLT3, JAK2, and TrkA with IC50 values of 3, 1, and 25 nM, respectively. | |
| An inhibitor of monoamine oxidase (MAO) and prostacyclin synthase. Potently suppresses the enzymatic activity of Lysine-Specific Demethylase 1 (LSD1) (IC50 2 μM for BHC110/LSD1). When combined with GSK-3 Inhibitor CHIR99021... | |
| An irreversible inhibitor of serine proteases (such as thrombin, trypsin and chymotrypsin) and mammalian acetylcholinesterase . It causes sulfonylation of the active-site serine residues. Inhibits cysteine proteases like papain (reversible... | |
| Anti-tumor agent isolated from the bark of the yew tree. A patient with breast cancer and SCD had a painful crisis after receiving paclitaxel as part of her chemotherapy regimen. | |
| Antibiotic which acts as a potassium (K+) ionophore. Induces K+ conductivity in cell membranes. Also active in vitro against Mycobacterium Tuberculosis, and as an apoptosis inducer. Valinomycin is used diagnostically... | |
| AZD0530 is a dually active inhibitor of c-Src and Bcr-ABL, on bone resorption. AZD0530 inhibited tumor growth in a manner independent of dose and inhibited phosphorylation of focal adhesion kinase... | |
| Belongs to an alkylphospholipid class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine induces apoptotic cell death in a... | |
| Belongs to the family of orphan ligands which include polyketides like leptomycin B, callystatin A and other related compounds. Cytotoxic secondary metabolite (IC50=50 pg/ml in mouse cell line L929) That... | |
| Benzodiazepine antagonist. | |
| Biological buffer with a pKa of 6.15 (20°C). Useful in plant tissue culture. | |
| Biotinylated form of S-100b protein from porcine brain (product S-2112). S-100b is composed of β-subunits, purified from porcine brain. Elevated S-100b serum levels are markers of stroke and cerebral edema. | |
| Biotinylated form of S100 alpha protein purified from porcine brain (product S-2098). The S-100 proteins are acidic Ca2⺠binding proteins found predominately in glial cells. Product is not... | |
| BioVision's loading Buffer (3X) is a ready-to-use buffer solution for the preparation of protein samples to be separated in SDS-polyacrylamide gel electrophoresis (SDS-PAGE). | |
| Brain- permeable. A potent and selective sirtuin 2 deacetylase (SIRT2) inhibitor. Reduces neuronal cholesterol by inhibiting SIRT2 activity. | |
| BV-7604 | |
| Cell permeable adenylate cyclase inhibitor. | |
| Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondra. Selectively blocks oxidative stress-induced necrotic cell death. (0.1μM Necrosis inhibitor 2 prevented Ëœ50% cell death in H9C2 cells... | |
| Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondria. Selectively blocks oxidative stress-induced necrotic death (0.1μM Necrosis Inhibitor 5, prevented Ëœ50% cell death in H9C2 cells exposed... | |
| Cell permeable SOD mimetic. Also a peroxynitrite scavenger but not a Nitric Oxide NO scavenger. Attached are published references from researchers who have used our MnTBAP product. We respectfully thank... | |
| Cell permeable SOD mimetic. Catalyzes the dismutation of O2- even in the presence of excess EDTA. | |
| Cell permeable, potent competitive inhibitor of factor inhibiting HIF (Hypoxia-inducible Factor) asparagine hydroxylase (FIH, IC50 0.4mM). Does not inhibit PHDs (prolyl hydroxylase domain-containing proteins; HIF-PHs). | |
| Cell permeable, selective inhibitor of Src family tyrosine kinases. | |
| Cell permeable. Acts as a positive regulator of autophagy, acting via mTOR-independent mechanism. SMER28 increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and... | |
| Cell-permeable, Adenylate cyclase inhibitor. (IC50-250uM). | |
| Cell-permeable, small molecule agonist of TGR5 G-protein coupled receptor. This agonist has shown to increase glucagon like peptide-1 (GLP-1) secretion from primary intestinal cells. | |
| Cell-permeable. A 10 mM (1 mg in 321 μl) solution of Thiazovivin (Cat. No. 1681-1) in anhydrous DMSO. | |
| Cell-permeable. A derivative of Wortmannin (Cat. No. 1670-1), that potently and irreversibly inhibits PI 3-kinase with selectivity for p110⺠(IC50 = 0.1 nM). Displays antitumor activity. | |
| Cell-permeable. A dipeptide that acts as a selective and reversible PPARγ antagonist (KD ~ 8 μM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner... | |
| Cell-permeable. A high affinity synthetic ligand specific to both retinoic acid-related orphan receptors É' (RORÉ') and γt (RORγt). SR1001 inhibits interleukin-17 (TH17) cell differentiation and function as well as suppressing... | |
| Cell-permeable. A high-affinity small molecule inhibitor of KMO (kynurenine 3-monoxygenase or kynurenine 3-hydroxylase)(Ki = 4.8 nM, IC50 = 37 nM). | |
| Cell-permeable. A macrophage migration inhibitory factor (MIF) antagonist. ISO-1 inhibits MIF pro-inflammatory activities by targeting MIF tautomerase activity. Also inhibits tumor necrosis factor (TNF) release from macrophages isolated from LPS-... | |
| Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and... | |
| Cell-permeable. A peptide-based inhibitor, PY*LKTK-mts (mts = membrane translocating sequence) that selectively inhibits constitutive and ligand-induced activation of Stat3 in vivo. Also suppresses transformation by Src oncoprotein that requires constitutive... | |
| Cell-permeable. A potent and ATP-competitive inhibitor of PDGF, VEGF and FGF receptor tyrosine kinases (RTKs) with IC50 values of 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2. FGFR1... | |
| Cell-permeable. A potent and selective HDAC6 (histone deacetylase 6) inhibitor. Displays 1093-fold selectivity over HDAC1 (IC50 values of 15 nM for HDAC6 vs 16.4 μM for HDAC1). Tubastatin A was... | |
| Cell-permeable. A potent and selective inhibitor of PI 3-K isoforms p110β/p110δ(IC50 p110β = 0.13 μM, p110δ = 0.63 μM). | |
| Cell-permeable. A potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) (IC50 = 8 nM). Displays >33-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα. | |
| Cell-permeable. A potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: IC50 = 37 nM for hSCD1, (4 nM for mSCD1). Also exhibited in vivo efficacy with dose-dependent desaturation... | |
| Cell-permeable. A potent and selective inhibitor of Stat3 SH2 domain:pTyr interactions; also disrupts the binding of Stat3 to the IL-6R/gp130 peptide, GpYLPQTVNH2 and induces antitumor effects in vitro. | |
| Cell-permeable. A potent and selective multi-targeted tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor and c-kit, key proteins responsible for tumor growth and... | |
| Cell-permeable. A potent and specific inhibitor of Cdc42, a small GTPase of the Rho subfamily (IC50 = 2 μM). | |
| Cell-permeable. A potent antagonist of Hedgehog (Hh) signaling pathway. Antagonizes smoothened receptor activity (KD = 12 nM) and inhibits SAG (Cat. No. 1939-500,1000) activity. SANT-2 should be a useful tool... | |
| Cell-permeable. A potent bisindolylmaleimide inhibitor of protein kinase C (PKC) isoforms (IC50 = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively). It inhibits... | |
| Cell-permeable. A potent inhibitior of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (Kd = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM in... | |
| Cell-permeable. A potent inhibitor of the human epidermal growth factor receptor 2 (HER2) tyrosine kinase (IC50 = 6 nM). Displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. | |
| Cell-permeable. A potent, selective and ATP-competitive inhibitor of PI 3-kinase β (IC50 = 5 nM for p110β). Inhibits other PI3K isoforms at higher concentrations (IC50 = 0.1 μM for p110δ,... | |
| Cell-permeable. A potent, selective, and reversible MMP-9 Inhibitor (IC50 = 5 nM). Inhibits MMP-1 (IC50 = 1.05 μM) and MMP-13 (IC50 = 113 nM) only at much higher concentrations. | |
| Cell-permeable. A potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk) (Ki = 10 nM for mClk1/Sty; IC50 = 20 nM, 200 nM, >10 μM, and 15 nM for... | |
| Cell-permeable. A selective JAK3 inhibitor. Blocks STAT signaling and induces apoptosis via down-regulation of anti-apoptotic gene expression. | |
| Cell-permeable. A selective NOD1 (nucleotide-binding oligomerization domain 1) inhibitor. Selectively inhibits NOD1-dependent activation of NF-kB in HEK293 cells (IC50 = 0.56&plusm;0.04 μM). Displays high selectivity (>36-fold) over MDP-stimulated signaling in... | |
| Cell-permeable. A selective, non-competitive Calpain inhibitor (Ki = 210 nM and 370 nM for Calpain-1 and Calpain-2, respectively). Interacts with the calcium-binding domain of calpain. | |
| Cell-permeable. A sulfonylhydrazone (Shz) small molecule that acts as an enhancer of myocardial regenerative repair by stem cells. Potently induces Nkx2.5 and a subset of other cardiac markers, including myocardin,... | |
| Cell-permeable. A synthetic tricyclic nucleoside which acts as a specific inhibitor of the Akt signaling pathway. It selectively inhibits the phosphorylation and activation of Akt1, -2 and -3 but does... | |
| Cell-permeable. A TGE-β type I receptor (ALK5) inhibitor. Inhibits ALK5 autophosphorylation (IC50 = 4nM). Can replace one of the four reprogramming factors Sox-2. RepSox has been successfully used in the... | |
| Cell-permeable. A thiazolidinedione (TZD) derivative that acts as a selective peroxisome proliferator-activat ed receptor gamma (PPARγ) agonist (EC50 = 0.69 μM). An antidiabetic agent; improves insulin sensitivity. | |
| Cell-permeable. A useful negative control for FMK-labeled caspase inhibitors. Also, an irreversible inhibitor of cathepsins B, L, and S, and likely cathepsin H, as well as cruzain and papain. | |
| Cell-permeable. An antipsychotic drug and D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7 receptor. A Stat5 inhibitor; decreases Stat5 tyrosine phosphorylation, but does not affect Bcr-Abl... | |
| Cell-permeable. An irreversible ubiquitin-activating enzyme (E1) inhibitor (IC50 10 μM). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-κB activation, blocks degradation of p53, increases p21 levels and induces apoptosis... | |
| Cell-permeable. An oxindole derivative that acts as a potent, reversible, and ATP-competitive Spleen tyrosine kinase (Syk) inhibitor (IC50 = 14 nM). Has been shown to effectively inhibit FcεRI-mediated degranulation in... | |
| Cell-permeable. Salermide is an inhibitor of SIRT1 and SIRT2. In vitro, Salermide has a stronger inhibitory effect on SIRT2 than on SIRT1. It induces massive apoptosis in tumor cells through... | |
| Cell-permeable. Selectively induces neuronal differentiation of primary hippocampal neural progenitor cells. It is more potent and selective compared to retinoic acid. Also suppresses astrocyte differentiation. | |
| Cell-permeable. Selectively inhibits the tyrosine kinase activity of Jak3 with an IC50 value of 78 μM without affecting the enzymatic activity of JAK1, JAK2, or other protein tyrosine kinases. Also... | |
| Cell-permeable. UNC0638 is a potent G9a HMTase inhibitor, exhibiting an IC50 value of 50 value of 19 nM, but is more than 10,000-fold selective against SET7/9 (a H3K4 HMTase), SET8... | |
| Chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Reversibly blocks p53 dependent transcriptional activation and apoptosis. Inquire for bulk pricing. | |
| Control compound for 6BIO. | |
| CpG oligodeoxynucleotide (Type C) with phosphorothioate backbone. Specific ligand for TLR9 (Toll-like receptor 9). For inactive control compound see ODN M383. | |
| Cytotoxic secondary metabolite that inhibits cell growth of mammalian cell lines in the picomolar range (IC50=0.2ng/ml with L929 mouse cells) including multi-drug resistant HeLa cells (IC50=0.1ng/ml with KB-V1). | |
| Description: P21-activated kinase 1, kinase domain, corresponding to 248 - 545 of full-length human PAK1. Protein Type:Kinase. Source:E. coli. *Underlined amino acids (GPHM) are from HRV 3C cleavage site. *Phosphorylated... | |
| Endothelin converting enzyme inhibitor (ECE) (IC50=0.68μM). Inhibits neutral endopeptidase 24.11 & neprilysin 2. | |
| Epidermal Growth Factor Inhibitor. Inhibitor of the mitogenic activity of epidermal growth factor (EGF). A G1 phase cell cycle inhibitor displaying antiproliferative behavior against human cell lines KB and K562... | |
| Extracelluar domain of human TNF-R2 (aa1-257) is fused to the Fc portion of human IgG1. The recombinant fusion protein is produced in HEK 293T cells. rhTNF-R2:Fc can be used to... | |
| Extracellular domain of human TNF-R1 (aa 1-211) is fused to the Fc portion of human IgG1. The recombinant fusion protein is produced in HEK 293T cells. Application: rhTNF-R1:Fc fusion protein... | |
| Fluorogenic proteasome substrate. Also acts as a substrate for many other proteinases. Good for measuring the chymotrypsin-like peptidase activity of the 20S proteasome | |
| Fluorogenic substrate for Alzheimer's disease amyloid A4-generating enzymes and for measuring the peptidase activity of the 20S proteasome. | |
| Fluorogenic substrate for MMP-2 and MMP-7. | |
| Fluorogenic substrate for MMP-3 and MMP-9. | |
| From Streptomycs Platensis. Trichostatin A inhibits Histone deacetylase. Trichostatin A blocks cell cycle progression at the GI phase in Hela cells. Trichostatin A also demonstrates immunosuppressive activity. * Bulk stock... | |
| GABAA receptor agonist. (Inquire for HBr formulation). See M-1057 for HBr formulation. | |
| Glycopeptide antibiotic that inhibits gm-positive microorganisms. Interferes with cell wall synthesis. Often used with cefotaxime or carbenicillin to produce a wide spectrum of activity against gm-positive and g negative bacteria. | |
| H-Tyr-Pro-Ser-Lys-Pr o-Asp-Asn-Pro-Gly-Gl u-Asp-Ala-Pro-Ala-Gl u-Asp-Met-Ala-Arg-Ty r-Tyr-Ser-Ala-Leu-Ar g-His-Tyr-Ile-Asn-Le u-Ile-Thr-Arg-Gln-Ar g-Tyr-NH2. Merck Index: (Antimycin A1) & 721 (Antimycin A3) | |
| High purity biological buffer. Pre-weighed based on molar weight instead of grams in ready-to-use pouches. Stock solutions easy and fast to prepare. DNase, RNase and Proteases not detected. Ready-to-use. Prepare... | |
| High Purity phospholipid utilized for liposome production. * Product is currently unavailable from regular stock, please inquire for lead time & pricing details ** | |
| Highly cell permeable purine compound that acts as a selective and ATP-competitive inhibitor of Cdks (IC50=6.6μM, 0.41μM, 5.5μM, 15μM and 3.9μM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk4/cyclin D, Cdk5/p25 and... | |
| Highly purified for use in molecular biology application. Contact A.G. Sci for other sizes & pricing, as well as detailed product specification data. (Reported pH range 10.5 - 11.5) | |
| Highly specific inhibitor of acyl-coenzyme A:cholesterol acetyltransferase 2 (ACAT2). | |
| Host: Human recombinant MGMT produced in E. coli. Purified with Glutathiose-Sepharos e 4B and thrombin cleavage. Specific Activity: 100 units/μl. 1 unit removes 100fmol O6-methylguanine from DNA. | |
| Human TWEAK is a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. TWEAK, like many ohter members of the TNF family, is able to induce... | |
| Inactive negative control for use in studies involving olomoucine | |
| Induces differentiation of human promyelocytic leukemia cells. In COS-7 cells nidulal selectively activates AP-1 dependent signal transduction in a mannner similar to TPA. | |
| Inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer... | |
| Inhibitor of calpain I, calpain II, cathepsin B and cathepsin L. Inhibits neutral cysteine proteases and the proteasome. | |
| Inhibitor of histone deacetylase (HDAC). Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation. | |
| Inhibitor of tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1). Inhibits αFGF-induced tyrosine phosphorylation of ERK1 and ERK2 (IC50=20-4μM) and the tyrosine phosphorylation of the PDGF receptor and... | |
| Inhibitor of VEGF-induced angiogenesis. Also anti-allergic agent. | |
| Inhibits activation of MAP kinase. Also anti-inflammatory and anti-secretory. Parthenolide Inhibits TNF/IL-1β - or TNF-Induced Production of IL-81 Parthenolide Inhibits I B Kinase, NF- B Activation, and Inflammatory Response in... | |
| Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in the activation... | |
| Inhibits non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway:... | |
| Inhibits soluble TRAIL-induced apoptosis in a conc. Rang of 50-100 μg/ml. | |
| Inhibits soluble TRAIL-induced apoptosis in a conc. Range of 2-10 ug/ml. | |
| Inhibits soluble TRAIL-induced apoptosis. Range of 0.1-0.5ug/ml. | |
| Inhibits Stat3.Stat3 complex formation and Stat3-DNA binding activity in vitro (IC50 = 86 &plusm; 33 μM) and Stat3-dependent transcriptional activities. S3I-201 inhibits the expression of the Stat3-regulated genes encoding cyclin... | |
| Inhibits the GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) as well as synergizes the Wnt/β-catenin signaling pathway. The Wnt/β-catenin signaling pathway regulates cell fate and behavior during embryogenesis, adult... | |
| Inhibits the protein tyrosine kinase Syk. | |
| Inhibits TNF-α biosynthesis. Angiogenesis inhibitor. | |
| Ins(1,2,5,6)P4 | |
| Ins(1,4,5,6)P4, K+ | |
| Ins(1,4,5,6)P4, NH4+ | |
| Ins(2,4,5)P3 | |
| Ins(3,4,5,6)P4 | |
| Ionophoric. Chelates monovalent cations, preferably sodium ions and transports them passively through biological membranes. Displays antimicrobial and cytotoxic properties and selective and potent antimalarial activity. | |
| L-type Ca2+ channel agonist. Vasodilator. | |
| Ligand with various binding profiles dependent on vanilloid receptors. Agonist at rat TRPV1 (EC50 between 3 and 10μM), but reported to be inactive at human TRPV1 (EC50>10μM). Induces apoptosis through... | |
| Liver-selective nitric oxide donor that blocks TNF-α-induced apoptosis and toxicity. | |
| Low-affinity NMDA receptor antagonist. Stimulates dopamine release. ** Inquire for lead time. | |
| Macrotetrolide antibiotic which acts as a monovalent cation ionophore and demonstrates high selectivity for ammonium and potassium. Our results showed that nonactin is a potent inhibitor of intracellular glycosylation.1 Nonactin... | |
| Meropenem is an ultra-broad spectrum, beta-lactam antibiotic belonging to the subgroup carbapenem and is used to treat a wide variety of infections, including meningitis and pneumonia. Bulk pricing available, inquire... | |
| Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases[1]. It inhibits phospholipase A2 (PLA2) and fatty... | |
| Mizoribine, immunosuppressant that is believed to achieve immunosuppression by inhibiting DNA synthesis in the S phase of the cell cycle thus preventing the division and proliferation of lymphocytes. Recently it... | |
| mTOR inhibitor with anti-cancer activity. It has anti-angiogenic effects which may contribute to the antitumor activity of temsirolimus observed in breast cancer. Temsirolimus shows synergistic in vivo anti-myeloma effects in... | |
| Mycotoxin commonly found in grains. | |
| Mycotoxin which inhibits the uptake of potassium. | |
| n-Octyl-β-D-Glucopyr anoside, a non-ionic detergent, intended for solubilizing membrane-bound proteins in their native state and for the preparation of lipid vesicles. n-Octyl-β-D-Glucopyr anoside well defined chemical structure, small uniform micelles... | |
| NANA is a predominant Sialic acid in mammalian cells. NANA residues are found in glycoproteins found in cell membrane and glycolipids in neuronal membranes. | |
| Natural Ca2+ blocker, which acts at the sacroplasmic reticulum. Contact A.G. Scientific to confirm lead time from stock. | |
| Natural occurring form. Substrate for PIP4K α and β. Inhibited by PI(4,5)P2. | |
| Natural occurring form. Substrate for PIP4K α and β. | |
| Natural occurring form. Substrate for PIP5K. Inhibited by PI(4,5)P2. | |
| Nedaplatin is an analog of platinum-based anti-cancer drugs such as carboplatin and cisplatin. It has cytotoxic activity in human ovarian tumors. The administration of either nedaplatin or cisplatin prior to... | |
| Non-ionic Detergent & Emulsifier. (CMC 0.35 mM, HLB 12.4, Cloud Point 22°C). 10% aqueous solution of Triton X-114 highly purified & aseptically filled under GMP conditions with pharmaceutical grade water. | |
| Non-ionic Detergent useful for isolation of membrane proteins. (CMC 0.2-0.9 mM, HLB 13, Cloud Point 64°C). 10% aqueous solution of Triton X-100 highly purified & aseptically filled under GMP conditions... | |
| Non-ionic Detergent. 10% aqueous solution of Tween 80 of highly purified & aseptically filled under GMP conditions with pharmaceutical grade water. Extremely low aldehyde & peroxide impurities (100 μM) enable... | |
| Non-peptide tachykinin antagonist with strong affinity for NK1 and NK2 receptors. | |
| NU6102 is a 1,000-fold more potent inhibitor of CDK1/cyclin B (IC50=9.5 nM) and CDK2/cyclin A3 (IC50=9.5 nM) than NU2058. NU6102 is selective for CDK1 and CDK2 compared to CDK4/D1 (IC50=1.6... | |
| Obestatin decreases food intake and body weight in rodents. Obestatin also counteracts ghrelin's effect by decelerating gastric emptying and decreasing intestinal contractility. | |
| Olaparib | |
| ONPG is used in colormetric and spectrometric assays for the detection of β-galactosidase activity which are of interest in clinical, enviromental, food and molecular biology arenas. ONPG is hydrolysed by... | |
| Ophiobolin A is the dominant member of a class of phytotoxic metabolites produced by plant pathogenic fungi. Ophiobolin A acts as an inhibitor of calmodulin action in calcium regulation. In-house... | |
| Ophiobolin B is a minor member of a class of phytotoxic metabolites produced by Bipolaris and other genera of plant pathogenic fungi. Ophiobolin B acts as an inhibitor of calmodulin... | |
| Ordoless disulfide reducing agent. More stable, resistant to air oxidation and effective than DTT. pH range is 1.5 to 8.5 | |
| Oridonin, a diterpenoid isolated from Rabdosia rubescens displays anti-inflammatory, anti-bacterial, anti-tumor effects and has been used for the treatment of human cancers, especially esophageal carcinoma. Exposure to oridonin induces apoptosis... | |
| Oxaliplatin is a third-generation, diaminocyclohexane-c ontaining platinum anti-cancer drug. The anticancer activity and the antitumor specificity of oxaliplatin mainly depend on human organic cation transporters (OCT) 1 and OCT2. | |
| OxiRed, which has been marketed under the name Amplex Red™ reagent, is a highly sensitive and stable probe for H2O2, is a fluorogenic (EX/EM = 535/587 nm) and Colorometric (l... | |
| P21-activated kinase 2, kinase domain, corresponding to 227 - 524 of full-length human PAK2. Protein Type:Kinase Source:E. coli *Underlined amino acids (GPM) are from HRV 3C cleavage site. *PAK2-KD sequence... | |
| Panobinostat (LBH589) is a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The IC50 values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective,... | |
| Paraherquamide A was first reported as a mycotoxin related to the indole tremorgenic mycotoxins. Subsequent research identified a potent non-toxic paralysis of nematodes which led to the metabolite's development as... | |
| Paraherquamide E is a member of the paraherquamide family which cause a potent non-toxic paralysis of nematodes and has led to investigation of their potential as anthelmintics. Although paraherquamide A... | |
| PBS-Tween buffer contains the non-ionic detergent Tween® 20 which acts through blocking. It has the ability to reduce non-specific binding and protein-protein interaction during the wash step in protein and... | |
| Pencillin-Streptomyc in is an antibacterial sterile-filtered solution used against both Gram-negative and Gram-positive bacteria in cell cultures. It is a combination of a beta-lactam and aminoglycoside antibiotic. Penicillin, the beta... | |
| Penicillin G Potassium is a naturally occurring beta lactam antibiotic produced by the Penicillium fungus. | |
| Peptide YY (3-36) [PYY3-36] is a Y2R agonist, inhibiting food intake and reducing weight gain in rats and humans after peripheral injection | |
| Pestalotin is a pyran-2-one metabolite produced by Pencillium decumbens. It has been reported to act as a gibberellin synergist and plant growth stimulator. Pestalotin did not influence elongation of rice... | |
| Phosphodiesterase inhibitor. Blocks the synthesis of TNF-α. | |
| Phosphoinositide 3-kinases (PI(3)K´s) phosphorylate the 3´-OH position of inositol phospholipids. The heterodi-meric complex consists of a catalytic subunit (p110α) and a regulatory adaptor subunit (p85α). Specific Activity: ~1nmole/min/mg using phosphatidylinositol... | |
| Phosphoinositide 3-kinases (PI(3)K´s) phosphorylate the 3´-OH position of inositol phospholipids. The heterodi-meric complex consists of a catalytic subunit (p110α) and a regulatory adaptor subunit (p85α). Specific Activity: ~4.5nmoles/min/mg using phosphatidylinositol... | |
| Phytotoxin. Causes plant cell necrosis at nanomolar concentrations. Demonstrated to be produced by bacterial nitrix oxide synthases (NOS). | |
| PI(3)P-Na+, di C16 | |
| PI(3,4,5)P3-Na+, di C8 | |
| PI(3,5)P2-Na+, di C16 | |
| PI(4,5)P2-Na+ di C16 | |
| Piericidin A is the major analogue of a family of pyridyl antibiotics isolated from selected Streptomyces sp. It is a specific, potent inhibitor of NADH-ubiquinone oxidoreductase (Complex I) that binds... | |
| Pimaricin is a macrocyclic tetraene originally isolated from Streptomyces natalensis in 1957. Pimaricin exhibits broad spectrum antifungal activity against yeast and filamentous fungi by binding specifically to ergoesterol to block... | |
| Pimecrolimus is a cell-selective inhibitor of inflammatory cytokines developed for the treatment of inflammatory skin diseases, such as allergic contact dermatitis, atopic dermatitis, plaque-type psoriasis, and irritant contact dermatitis. It... | |
| PKC 412 is an inhibitor of serine, threonine, and tyrosine kinases. A potential inhibitor of FLT-3 kinase, including mutant forms found in acute myeloid leukemia in vitro and in vivo. | |
| Pleuromutilin is a diterpene produced by several species of basidomycetes, notably the genus Pleurotus, discovered in 1951. Pleuromutilin is a potent and highly selective antibiotic active against a range of... | |
| Potent and cell permeable inhibitor of p38 (SAPK2a), IC50-30nM. Inhibits p38α and p38β isoforms. Good for probing p38 MAP kinase function in vivo and in vitro. | |
| Potent and cell permeable Tie-2 inhibitor (IC50=600nm). | |
| Potent and highly specific inhibitor of all ubiquitin deconjugating enzymesin including UCHs, USPs, and DUBs. Specific Activity: Ki=2.5nM vs. UCH Isopeptidase-T. Product is useful in the stabilisation of ubiquitin-protein conjugates... | |
| Potent and selective inhibitor of cyclin-dependent kinases (cdks). Selective for CDK1, CDK2, and CDK5. Attached is a published references from researchers who have used our Roscovitine product. We respectfully thank... | |
| Potent and specific inhibitor of MEK1 and MEK2. Blocks the production of inflammatory cytokines and matrix metalloproteinases. Does not inhibit PKA, PKC or CaM KII. | |
| Potent immunosuppressant; reported to be 10 to 100-fold more potent than cyclosporin (C1199). Fungal antibiotic. Apoptosis inducer, depletes cellular sphingolipids. Inhibits proliferation of an IL-2-dependent mouse cytotoxic cell line CTLL-1... | |
| Potent inhibitor of Ca activated K(maxi K) channel. inhibits binding of charybdotoxin. | |
| Potent inhibitor of Ca activated K(maxi K) channel. | |
| Potent inhibitor of yeast NADâº-dependent histone deacetylase Sir2p (IC50 = 60 μM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either... | |
| Potent mouse skin tumor promoter. Also activates Protein Kinase C. | |
| Potent, cell Permeable and selective inhibitor of p38 (SAPK2a). | |
| Potent, cell permeable cysteine thioether displaying anti-mitotic and anti-tumor properties. Inhibits mitosis by blocking basal and microtubule-activate d ATPase activities of the mitotic kinesin Eg5 (IC50=1 uM and 140nm). Induces... | |
| Potent, cell permeable non-tubulin-interact ing mitosis inhibitor. Blocks mitosis (IC50 = 14 μM) by binding to the mitotic kinesin Eg5, a motor protein required for spindle bipolarity. | |
| Potent, cell permeable non-tubulin-interact ing mitosis inhibitor. Blocks mitosis (IC50=600nM) by binding to the mitotic kinesin Eg5. | |
| Potent, high-affinity, selective and non-competitive NMDA receptor antagonist. | |
| Potent, reversible and cell permeable proteasome inhibitor. Inhibits NF-κB activation. Seeking published scientists that has used our MG-132? Click on the HOT LINK for the free scientific paper. http://www.fasebj.or g/content/23/2/503.f... | |
| Potent, reversible inhibitor of histone deacetylase 1 (HDAC1) and 3 (HDAC3). Induces cell growth arrest at both G1 and G2 phases. Induces apoptosis. | |
| Potent, water-soluble poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor. | |
| Powerful inhibitor of PKCδ. 10-fold more potent to PKCδ than PKCα or PKCβ. Also inhibits Ca2+/Calmodulin dependent kinase III. | |
| Preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM). Has no inhibitory activity towards HDAC8 (IC50>100 μM). | |
| Prepare a 1:5 dilution of KillerTRAIL™ or SuperKillerTRAIL™ with KillerTRAIL™ Storage and Dilution Buffer. For immediate use, keep prediluted KillerTRAIL™ or SuperKillerTRAIL™ on ice until adding to cells | |
| Procaspase-activatin g compound 1 (PAC-1) directly activates procaspase-3 to caspase-3, a transformation that allows induction of apoptosis even in cells that have defective apoptotic machinery. In cancer cells, PAC-1 had... | |
| Produced in E. coli. The extracellular domain of human TRAIL (aa95-281) is fused at the N-terminus to a His-tag and a linker peptide. Affinity purified. Note: this protein does not... | |
| Product is a synthetic microtubule inhibitor. | |
| Progesterone receptor antagonist; stimulates prolactin secretion. Also acts as Pgp inhibitor. | |
| Propidium Iodide (PI) binds to double-stranded DNA, but it can only cross the plasma membrane of nonviable cells. When viewed using a fluorescence microscope with a rhodamine filter, cells that... | |
| Protease Inhibitor Cocktail V, EDTA-Free is a cocktail of four protease inhibitors which has been optimized for the inhibition of serine, cysteine but not metalloproteases. Suitable for use as Protease... | |
| Protein A/G/L is a genetically engineered protein that combines the IgG binding profiles of all Protein A, Protein G and Protein L. It is a gene fusion product. Recombinant fusion... | |
| Protein G binds to the constant region of many species of immunoglobulin G. Protein G can be used to detect, quantify and purify IgG antibodies and antibody/antigen complexes. Recombinant Protein... | |
| Protein L has the unique ability to bind through kappa light chain interactions without interfering with the antibody's antigen-binding site. This gives Protein L the ability to bind a wider... | |
| Proteinase K is a non-specific serine protease used in the following applications: inactivation of Rnase and Dnases, isolation of high molecular weight DNA, isolation of RNA or the isolation of... | |
| Purified from bovine brain. Contains primarily stearic and nervoic acids. Precursor to ceramide second messengers via the action of shingomyelinase. | |
| Quinomycin A is a cyclic depsipeptide metabolite, Quinomycin A has broad activity against bacteria, fungi, and viruses. Also used as anti-tumor agent. Recent studies show Quniomycin A to be a... | |
| Radicicol, a macrocyclic antifungal antibitotic, has been shown to bind to a highly conserved pocket in the Hsp90 (heat shock protein 90) chaperone protein and inhibit the intrinsic ATPase activity... | |
| Recommended for purification of proteins containing His.Tag sequences. A specially formulated cocktail of five protease inhibitors with broad specificity for the inhibition of cysteine, serine, aspartic, thermolysin-like proteases and aminopeptidases. | |
| Recommended for use with mammalian cell and tissue extracts. A specially formulated cocktail of six protease inhibitors with broad specificity for the inhibition of aspartic, cysteine and serine proteases as... | |
| Recommended for use with plant cell extracts. A specially formulated cocktail of six protease inhibitors with broad specificity for the inhibition of aspartic, cysteine, serine, metalloproteases as well as aminopeptidases. | |
| Resiniferatoxin-type phorboid vanilloid with capsaicin-like selectivity for TRPV1 (Ki=60nM). Reported to have tumor promoting properties. | |
| Resistoflavine is a rare, boat-shaped, pentacyclic polyketide isolated from several species of Streptomyces, often co-produced with resistomycin. Resistoflavine exhibits weak antibacterial activity against Gram positive and Gram negative bacteria and... | |
| Resveratrol is a minor product found in wine and grapes. Found to reduce serum lipids, inhibit platelet aggregation. Resveratrol act as a chemopreventative agent and as an antioxidant. Resveratrol |... | |
| Reveromycin C is a minor analogue of the reveromycin complex isolated from a Streptomyces sp. Published information suggests that reveromycin C exhibits comparable potency to reveromycin A, its butyl homologue. | |
| Reveromycin D, the isopentyl analogue, is a minor component of the reveromycin complex isolated from a Streptomyces sp.. Published information on reveromycin D suggests that it is more active than... | |
| Riveromycin is a much less active analogue of Reveromycin A formed by rearrangement of the 6:6 spiroketal to a 5:6 spiroketal. Lacking much of the biological activity of Reveromycin A,... | |
| Rosuvastatin belongs to a class of compounds called statins that is used to reduce plasma cholesterol levels and prevent cardiovascular disease. It competitively inhibits hydroxymethylglutary l-coenzyme A (HMG-CoA) reductase, an... | |
| S-100 alpha protein purified from porcine brain. The S-100 proteins are acidic Ca2⺠binding proteins found predominately in glial cells. Evidence indicates that upon binding to Ca2... | |
| S-100b isoform composed of ββ-subunits, purified from porcine brain. Elevated S-100b serum levels are markers of stroke and cerebral edema. The S-100 proteins are acidic Ca2⺠binding proteins,... | |
| Sandramycin is a high molecular weight, symmetric, cyclic depsipeptide belonging to the quinomycyn class produced by Kribbella sp.. Sandramycin has potent antitumor and antibacterial activity and is thought to act... | |
| SB-203580 is a pyridinyl imidazole which acts as a specific inhibitor of p38 MAP Kinase. SB-203580 does not inhibit the MAP kinase homologs JNK and p42 MAP kinase. Attached is... | |
| SDS Solution (10% in Hâ‚‚O) | |
| Second generation orally active CCR5 antagonist, which is also a potent inhibitor of HIV-1 entry into target cells, with a mean IC50 =0.46 nM and IC90 =1~10 nM to HIV... | |
| Selective inhibitor of anandamide uptake that does not activate vanilloid receptor VR1. | |
| Selective inhibitor of cAMP-specific phophodiesterase, PDE IV. Attached is a few published reference from researchers who have used our Rolipram product. We respectfully thank them for their trust in our... | |
| Selective Inhibitor of Protein Kinase C. | |
| Selective mGluR antagonist. | |
| Selective, potent cAMP phosphodiesterase inhibitor. Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells. | |
| Selectively binds to PI3K SH3 (Km=7.6 μm). SEQUENCE: Arg-Lys-Leu-Pro-Pro- Arg-Pro-Arg-Arg | |
| Selectively inhibits P-glycoprotein. Effectively reverses Pgp-mediated drug resistance in NCI.ADR cells, but has not effect on the drug sensitivities of MCF7/VP cells that overexpress MRP1. | |
| Sensitivity: 0.2ng/ml. Quantity: 96 wells. Application: Quantitative measurement of human resistin in serum, plasma and tissue culture medium. | |
| Simvastatin | |
| Sincalide corresponds to the C-terminal octapeptide of cholecystokinin (CCK) which acts on receptors within the gallbladder wall causing it to contract. Cholecystography. | |
| Source: Bacillus Megaterium. Activity: > 5μ/mg | |
| Source: Goat. Immunogen: Synthetic peptide corresponding to aa 33-63 of the extracelluar domain of human TRAIL-R3. Specificity: Recognizes human TRAIL-R3. | |
| Source: Produced in E. coli. Lyphilized from 25mM TRIS, pH7.5, containing 25mM Sodium Chloride. Reconstitution: Reconstitute in 200μl distilled water, let dissolve completely. Application: ELISA, Western blot. | |
| Source: Rabbit. Immunogen: Raised against complete O6-methylguanine-DNA methyltransferase of human origin. Specificity: Recognizes human MGMT Application: WB (1:100-1:1000). | |
| Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 1-18 (M1VDTESPICPLSPLEADD 18) of mouse PPARα. Specificity: Recognizes mouse, human, and rat PPARα. Detects a ~52 kDa band in WB. Does not... | |
| Source: Rabbit. Immunogen: synthetic peptide corresponding to aa 30-47 of human SPRR2A and SPRR2B . Specificity: Recognizes human SPRR2. Application: ICC, IHC(ps), WB. | |
| Source: Rabbit. Immunogen: Synthetic peptite corresponding to the C-terminal region (I484KKTETDMSLHPLLQ4 98) of PPARγ2. Specificity: Recognizes mouse & rat PPARγ2 (~55 kDa) in WB. Also reacts with rec. rat PPARα | |
| Source: Rabbit. Immunogen: Unique Synthetic peptide corresponding to aa 1-14 (M1EQPQEETPEAREE14) of mouse PPARδ. Sequence is 86% conserved in human PPARδ. Specificity: Recognizes mouse PPARγ. Detects a ~49 kDa band... | |
| SP600125, SP-600125 is a potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40nM for JNK-1 and JNK-2 and 90nM for JNK-3). SP600125, SP-600125 exhibits... | |
| Specific cGMP-phosphodiestera se inhibitor (PDE5: IC50=0.2-0.8μM, PDE1: IC50=2.6μM, PDE2: IC50>10μM, PDE3: IC50>10μM, PDE4: IC50>10μM). Handling: Warning! Toxic. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means... | |
| Specific, compeptitive transition state substrate analog inhibitor of dipeptidyl peptidase IV (DPP-IV, DPIV, CD26, CD-26). Useful in diabetes research, as well as, protein preservation studies & transport. | |
| ST638 is a tyrosine kinase inhibitor (IC50 = 370 nM). It suppresses tyrosine phosphorylation induced by tumor necrosis factor (TNF-α) and phorbol myristate acetate (PMA) in neutrophils and by angiotensin... | |
| Stauprimide is a semi-synthetic analogue of the staurosporine family of indolocarbazoles. Stauprimide was first published in 1994 as part of an extensive structure-activity investigation to improve the selective inhibition of... | |
| Stem Cell Fate Regulator Set IV is a convenient set of three small molecules useful for promoting the survival of embryonic stem cells (ESCs). Stem Cell Fate Regulator Set IV... | |
| Substrate for PIP5K. Inhibited by PI(4,5)P2. | |
| Substrate of PI3-kinase II & III, used for high throughput screening. Synthetic, free acid. Soluble in organic solvents, can be brought into aqueous media as lipid vesicles using brief sonification. | |
| Sulochrin is a fungal metabolite isolated from a number of Aspergillus and Penicillium sp.. An antiangiogenic agent, it inhibits vascular endothelial growth factor (VEGF) leading to inhibition of capillary-like tube... | |
| Sunitinib is a potent inhibitor of CSF-1 receptor kinase in an enzyme assay, with an IC50 of 7 nM, and inhibits receptor phosphorylation in a cellular assay with an IC50... | |
| Survivin, a member of the inhibitor of apoptosis (IAP) family, is also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5 and in humans is encoded by the BIRC5 gene. | |
| Synthetic peptide corresponding to aa 1-16 (M1GETLGDSPIDPESDS16 ) of human PPARg2. Specificity: Recognizes mouse PPARg2. Detects a band of ~56 kDa by Western Blot. Does not cross-react with PPARa or... | |
| Synthetic peptide corresponding to aa 33-63 of the exptracllular domain of human TRAIL-R3. | |
| Synthetic peptide corresponding to aa 68-94 of the extracellular domain of human TRAIL-R2. | |
| Teicoplanin is a lipoglycopeptide antibiotic extracted from Actinoplanes teichomiceticus. Acts against Gram-postive bacteria including methicillin-resistan t Staphylococcus aureus and Enterococcus fecalis. Its mechanism of action is through inhibition of bacterial... | |
| TES is used to make buffer solutions. It has a pKa value of 7.550 (I=0, 25°C).[1] It is one of the Good's buffers and can be used to make buffer... | |
| Tetracycline is a broad spectrum protein synthesis inhibiting antibiotic. | |
| the (S)-enantiomer of the potent cyclin-dependent kinase (cdk) inhibitor Roscovitine (#R1016). Potently inhibits p34cdc2/cyclin B kinase (ICâ‚…â‚€ = 800 nM). | |
| The free form of pNA can be used as a colorimetric marker and reference standard in colorimetric enzyme assays using pNA-based substrates. | |
| The kinase assays with recombinant JNK1α1 enzyme in the presence or absence of the L-JNKI1 or TAT peptides were performed as described. The L-TAT peptide serves as a control. In... | |
| The macrolide antibiotic Venturicidin B, isolated from a Streptomyces sp., is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector. Venturicidin B was originally isolated... | |
| The major flavanone found in grapefruit. Acts as an antioxidant, free radical scavenger and carbohydrate metabolism promoter. Shows cytotoxicity in various human cell lines and promotes apoptosis in rat C6... | |
| The mitogen-activated protein (MAP) kinase intracellular signaling pathways are involved in the regulation of various cellular functions. One of these pathways, the Raf/MEK/ERK pathway, plays a major role in the... | |
| The peptide isused for blocking the antibody activity of Survivin (S-2148). It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of... | |
| The recombinant Protein A is a genetically engineered protein containing five Ig-binding regions of protein A and 6x His-tag on N-terminus and C-terminus. Cell wall binding region, albumin binding region... | |
| The set contains 10 μg of rhsTRAIL plus 2x50ug of an enhancer. In the presence of the enhancer, TRAIL induces apoptosis in a conc. Rang of 1-100ng/ml. | |
| Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit in vitro RNA synthesis directed by all three yeast... | |
| Thiostreptin is a thiazole-containing peptide antibiotic used in molecular biology applications. The thiostrepton-resista nt gene is commonly used as a selective marker for recombinant DNA/plasmid technologies. Thiostrepton inhibits protein synthesis... | |
| This formulation consists of 2mg Mitomycin C in 48mg NaCl. This is not a sterile formulation. Refer to M1108 for our standard Mitomycin C product. | |
| Tomatidine is a steroidal alkaloid found in the skins of unripe tomatoes. Structurally Tomatidine resembles cylopamine (Cat. No. 1578-5), but does not inhibit the Hedgehog (Hh) signaling pathway. May be... | |
| Tozasertib inhibits Aurora kinases A, B and C with Ki values of 0.6, 18 and 4.6 nM, respectively. It also inhibits Flt-3 and Abl as well as their mutant forms. | |
| Trichostatin C is the first example of a glucopyranosyl hydroxamate from nature. The conjugation may act to protect the less stable N-OH group of Trichostatin A. Trichostatin C displays antifungal,... | |
| Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC50 = 4 nM). Displays 1000-fold more selectivity for HDAC6 over other... | |
| Use in preparatioin of ion-selective membranes for ion-selective electrodes. | |
| Water soluble form. Substrate for PIP4K α and β. Inhibited by PI(4,5)P2. | |
| Water soluble form. Substrate for PIP4K α and β. | |
| Widely used diabetes inducer in rodents. It has been demonstrated that STZ's inhibition of Bata-cell O-GlcNAcase is the mechanism that accounts for its diabetogenic toxicity. | |
| Withaferin A is cell permeable and potent angiogenesis inhibitor from the family of withanolides.Withafe rin A inhibits endothelial cells (HUVEC) sprouting in vitro (IC50=12nM) and in vivo. Withaferin A exhibits... | |
| WY-14,643 is a widely used activator of peroxisome proliferator activator receptors (PPARs). WY-14,643 (PPAR activator) belong to the family of nuclear hormone receptor transcription factors. | |
| X-gal is an organic compound consisting of glactose linked to a substituted indole. X-gal is used to indicate whether a cell expresses the ß-glactosidase enzyme, which is encoded by the... | |
| X-Galactosaminide |
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