A.G. Scientific, Inc. SU 1498 S-2447

Description
A potent and selective inhibitor (IC50 = 700 nM) of vascular endothelial growth factor receptor 2 (VEGFR 2) (also known as Flk1). Very weak inhibitor of PDGFR-kinase (IC50 >50 μM), EGFR-kinase (IC50 >100 μM)and HER-2 kinase (IC50>100 μM). SU1498 has been shown to cause accumulation of phosphorylated ERK and inhibits its activity in vivo and in vitro by inhibition of ERK dephosphorylation.
Description
A potent and selective inhibitor (IC50 = 700 nM) of vascular endothelial growth factor receptor 2 (VEGFR 2) (also known as Flk1). Very weak inhibitor of PDGFR-kinase (IC50 >50 μM), EGFR-kinase (IC50 >100 μM)and HER-2 kinase (IC50>100 μM). SU1498 has been shown to cause accumulation of phosphorylated ERK and inhibits its activity in vivo and in vitro by inhibition of ERK dephosphorylation.

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Product
Description
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A.G. Scientific, Inc.
San Diego, CA, USA
SU 1498
S-2447
SU 1498 S-2447
A potent and selective inhibitor (IC50 = 700 nM) of vascular endothelial growth factor receptor 2 (VEGFR 2) (also known as Flk1). Very weak inhibitor of PDGFR-kinase (IC50 >50 μM), EGFR-kinase (IC50 >100 μM)and HER-2 kinase (IC50>100 μM). SU1498 has been shown to cause accumulation of phosphorylated ERK and inhibits its activity in vivo and in vitro by inhibition of ERK dephosphorylation.

A potent and selective inhibitor (IC50 = 700 nM) of vascular endothelial growth factor receptor 2 (VEGFR 2) (also known as Flk1). Very weak inhibitor of PDGFR-kinase (IC50 >50 μM), EGFR-kinase (IC50 >100 μM)and HER-2 kinase (IC50>100 μM). SU1498 has been shown to cause accumulation of phosphorylated ERK and inhibits its activity in vivo and in vitro by inhibition of ERK dephosphorylation.

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Technical Specifications

  A.G. Scientific, Inc.
Product Category Biological Materials
Product Number S-2447
Product Name SU 1498
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