A.G. Scientific, Inc. TMF-α Inhibitor T-1252

Description
A cell-permeable indoly-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promotin sbunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 μM). Shown to selectively inhibit TNF-α, but not IL-1β-induced IkB-α degradation in HeLa cells (IC50 = 4.6 μM).
Description
A cell-permeable indoly-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promotin sbunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 μM). Shown to selectively inhibit TNF-α, but not IL-1β-induced IkB-α degradation in HeLa cells (IC50 = 4.6 μM).

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Product
Description
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A.G. Scientific, Inc.
San Diego, CA, USA
TMF-α Inhibitor
T-1252
TMF-α Inhibitor T-1252
A cell-permeable indoly-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promotin sbunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 μM). Shown to selectively inhibit TNF-α, but not IL-1β-induced IkB-α degradation in HeLa cells (IC50 = 4.6 μM).

A cell-permeable indoly-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promotin sbunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 μM). Shown to selectively inhibit TNF-α, but not IL-1β-induced IkB-α degradation in HeLa cells (IC50 = 4.6 μM).

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Technical Specifications

  A.G. Scientific, Inc.
Product Category Biological Materials
Product Number T-1252
Product Name TMF-α Inhibitor
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