Panobinostat (LBH589) is a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The IC50 values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.23&plusm;0.06, 283&plusm;29, 75&plusm;4, 47&plusm;5 and 89&plusm;12 nM, respectively. And to A2780 proliferation, IC50 value is 4.6&plusm;1.8 nM.
| A.G. Scientific, Inc. | |
|---|---|
| Product Category | Biological Materials |
| Product Number | P-2380 |
| Product Name | Panobinostat (LBH589) |
