Highly cell permeable purine compound that acts as a selective and ATP-competitive inhibitor of Cdks (IC50=6.6μM, 0.41μM, 5.5μM, 15μM and 3.9μM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk4/cyclin D, Cdk5/p25 and Cdk7/cyclin H) and displays anti-cancer properties. Causes cell cycle arrest at the G2/M phase and induces apoptosis by activating caspases and downregulating survivin.
| A.G. Scientific, Inc. | |
|---|---|
| Product Category | Biological Materials |
| Product Number | N-1175 |
| Product Name | NU6140 |
