A.G. Scientific, Inc. Necrosis Inhibitor-5 N-1223

Description
Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondria. Selectively blocks oxidative stress-induced necrotic death (0.1μM Necrosis Inhibitor 5, prevented ëœ50% cell death in H9C2 cells exposed to 400μM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or Etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as, CCL4- induced acute liver and chronic liver fibrosis in rodent models. in vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress. in vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis. Ischemia & Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis & Acute Tubular Necrosis. Cell Media: Cell Therapy, CHO Growth. Lit. Ref.: H.J. Kim, et al.; Arch. Pharm Res, 33, 1813 (2010).
Description
Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondria. Selectively blocks oxidative stress-induced necrotic death (0.1μM Necrosis Inhibitor 5, prevented ëœ50% cell death in H9C2 cells exposed to 400μM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or Etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as, CCL4- induced acute liver and chronic liver fibrosis in rodent models. in vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress. in vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis. Ischemia & Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis & Acute Tubular Necrosis. Cell Media: Cell Therapy, CHO Growth. Lit. Ref.: H.J. Kim, et al.; Arch. Pharm Res, 33, 1813 (2010).

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A.G. Scientific, Inc.
San Diego, CA, USA
Necrosis Inhibitor-5
N-1223
Necrosis Inhibitor-5 N-1223
Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondria. Selectively blocks oxidative stress-induced necrotic death (0.1μM Necrosis Inhibitor 5, prevented ëœ50% cell death in H9C2 cells exposed to 400μM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or Etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as, CCL4- induced acute liver and chronic liver fibrosis in rodent models. in vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress. in vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis. Ischemia & Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis & Acute Tubular Necrosis. Cell Media: Cell Therapy, CHO Growth. Lit. Ref.: H.J. Kim, et al.; Arch. Pharm Res, 33, 1813 (2010).

Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondria. Selectively blocks oxidative stress-induced necrotic death (0.1μM Necrosis Inhibitor 5, prevented Ëœ50% cell death in H9C2 cells exposed to 400μM t-BuOOH for 2 hours LDH assay used).
Does not protect against staurosporine or Etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as, CCL4- induced acute liver and chronic liver fibrosis in rodent models.
in vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress.
in vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis.
Ischemia & Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis & Acute Tubular Necrosis.
Cell Media: Cell Therapy, CHO Growth.
Lit. Ref.: H.J. Kim, et al.; Arch. Pharm Res, 33, 1813 (2010).

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Technical Specifications

  A.G. Scientific, Inc.
Product Category Biological Materials
Product Number N-1223
Product Name Necrosis Inhibitor-5
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