A.G. Scientific, Inc. Necrosis Inhibitor-2 N-1221

Description
Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondra. Selectively blocks oxidative stress-induced necrotic cell death. (0.1μM Necrosis inhibitor 2 prevented ëœ50% cell death in H9C2 cells exposed to 400 μM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide induced apoptosis. Protects cells against cold shock, hypoxia abd oxidative stress in vitro. in vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress. in vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis. Ischemia & Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis & Acute Tubular Necrosis. Cell Media: Cell Therapy, CHO Growth. H.J. Kim et al. Arch. Pharm. Res. 33. 1813 (2010).
Description
Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondra. Selectively blocks oxidative stress-induced necrotic cell death. (0.1μM Necrosis inhibitor 2 prevented ëœ50% cell death in H9C2 cells exposed to 400 μM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide induced apoptosis. Protects cells against cold shock, hypoxia abd oxidative stress in vitro. in vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress. in vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis. Ischemia & Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis & Acute Tubular Necrosis. Cell Media: Cell Therapy, CHO Growth. H.J. Kim et al. Arch. Pharm. Res. 33. 1813 (2010).

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A.G. Scientific, Inc.
San Diego, CA, USA
Necrosis Inhibitor-2
N-1221
Necrosis Inhibitor-2 N-1221
Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondra. Selectively blocks oxidative stress-induced necrotic cell death. (0.1μM Necrosis inhibitor 2 prevented ëœ50% cell death in H9C2 cells exposed to 400 μM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide induced apoptosis. Protects cells against cold shock, hypoxia abd oxidative stress in vitro. in vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress. in vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis. Ischemia & Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis & Acute Tubular Necrosis. Cell Media: Cell Therapy, CHO Growth. H.J. Kim et al. Arch. Pharm. Res. 33. 1813 (2010).

Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondra. Selectively blocks oxidative stress-induced necrotic cell death. (0.1μM Necrosis inhibitor 2 prevented Ëœ50% cell death in H9C2 cells exposed to 400 μM t-BuOOH for 2 hours LDH assay used).
Does not protect against staurosporine or etoposide induced apoptosis. Protects cells against cold shock, hypoxia abd oxidative stress in vitro.
in vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress.
in vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis.
Ischemia & Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis & Acute Tubular Necrosis.
Cell Media: Cell Therapy, CHO Growth.
H.J. Kim et al. Arch. Pharm. Res. 33. 1813 (2010).

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Technical Specifications

  A.G. Scientific, Inc.
Product Category Biological Materials
Product Number N-1221
Product Name Necrosis Inhibitor-2
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