Inhibits activation of MAP kinase. Also anti-inflammatory and anti-secretory. Parthenolide Inhibits TNF/IL-1β - or TNF-Induced Production of IL-81 Parthenolide Inhibits I B Kinase, NF- B Activation, and Inflammatory Response in Cystic Fibrosis Cells and Mice. Aicha Saadane, Sophia Masters, et al, Jun 2007; 36: 728 - 736. NF-κB inhibitor parthenolide and the COX-2 inhibitor NS398 each inhibited hepatocellular carcinoma growth in a concentration-depend
ent manner. In addition, the combination of parthenolide and NS398 reduced the concentration of NS398 required to inhibit hepatocellular carcinoma growth.2 Parthenolide Cooperates with NS398 to Inhibit Growth of Human Hepatocellular Carcinoma Cells through Effects on Apoptosis and G0-G1 Cell Cycle Arrest. Matthew C. Ralstin, Earl A. Gage, et al, Jun 2006; 4: 387 - 399. Parthenolide Inhibits Taxol-Mediated Activation of IKK in the A549 Cell Line.3 Nuclear Factor- B Inhibition by Parthenolide Potentiates the Efficacy of Taxol in Non - Small Cell Lung Cancer In vitro and In vivo, Dianliang Zhang, Lin Qiu, et al, Jul 2009; 7: 1139 - 1149. The NF-κB inhibitor, parthenolide, may enhance chemosensitivity to paclitaxel in the treatment of patients with gastric cancer. 4 Enhances Response to Chemotherapy in Gastric Cancer. ITSURO SOHMA, YOSHIYUKI FUJIWARA, et al, Jan 2011; 8: 39 - 47. Parthenolide Disrupts the Interaction of MDM2 and HDAC1 with p53 and Activates p53.5 Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions. Y.N. Vashisht Gopal, Ekkawit Chanchorn, et al, Mar 2009; 8: 552 - 562.
Inhibits activation of MAP kinase. Also anti-inflammatory and anti-secretory.
Parthenolide Inhibits TNF/IL-1β - or TNF-Induced Production of IL-81 Parthenolide Inhibits I B Kinase, NF- B Activation, and Inflammatory Response in Cystic Fibrosis Cells and Mice. Aicha Saadane, Sophia Masters, et al, Jun 2007; 36: 728 - 736.
NF-κB inhibitor parthenolide and the COX-2 inhibitor NS398 each inhibited hepatocellular carcinoma growth in a concentration-dependent manner. In addition, the combination of parthenolide and NS398 reduced the concentration of NS398 required to inhibit hepatocellular carcinoma growth.2 Parthenolide Cooperates with NS398 to Inhibit Growth of Human Hepatocellular Carcinoma Cells through Effects on Apoptosis and G0-G1 Cell Cycle Arrest. Matthew C. Ralstin, Earl A. Gage, et al, Jun 2006; 4: 387 - 399.
Parthenolide Inhibits Taxol-Mediated Activation of IKK in the A549 Cell Line.3 Nuclear Factor- B Inhibition by Parthenolide Potentiates the Efficacy of Taxol in Non - Small Cell Lung Cancer In vitro and In vivo, Dianliang Zhang, Lin Qiu, et al, Jul 2009; 7: 1139 - 1149.
The NF-κB inhibitor, parthenolide, may enhance chemosensitivity to paclitaxel in the treatment of patients with gastric cancer. 4 Enhances Response to Chemotherapy in Gastric Cancer. ITSURO SOHMA, YOSHIYUKI FUJIWARA, et al, Jan 2011; 8: 39 - 47.
Parthenolide Disrupts the Interaction of MDM2 and HDAC1 with p53 and Activates p53.5 Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions. Y.N. Vashisht Gopal, Ekkawit Chanchorn, et al, Mar 2009; 8: 552 - 562.
