A.G. Scientific, Inc. MK-2206 M-2382

Description
A highly selective non-ATP competitive allosteric Akt inhibitor with IC50's of 8 nM, 2 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. MK-2206 potently inhibits phosphorylation of Thr³â°â¸ and Serâ´â·³ in 3T3-L1 adipocytes with IC50 values of 0.11 and 0.18 μM, respectively as well as downstream effects of insulin on GLUT4 translocation (IC50 = 0.47 μM) and glucose transport (IC50 = 0.14 μM). In addition, treatment with MK-2206 causes a robust, concentration-depend ent activation of autophagy in human glioma cell lines LN229 and T98G.
Description
A highly selective non-ATP competitive allosteric Akt inhibitor with IC50's of 8 nM, 2 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. MK-2206 potently inhibits phosphorylation of Thr³â°â¸ and Serâ´â·³ in 3T3-L1 adipocytes with IC50 values of 0.11 and 0.18 μM, respectively as well as downstream effects of insulin on GLUT4 translocation (IC50 = 0.47 μM) and glucose transport (IC50 = 0.14 μM). In addition, treatment with MK-2206 causes a robust, concentration-depend ent activation of autophagy in human glioma cell lines LN229 and T98G.

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A.G. Scientific, Inc.
San Diego, CA, USA
MK-2206
M-2382
MK-2206 M-2382
A highly selective non-ATP competitive allosteric Akt inhibitor with IC50's of 8 nM, 2 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. MK-2206 potently inhibits phosphorylation of Thr³â°â¸ and Serâ´â·³ in 3T3-L1 adipocytes with IC50 values of 0.11 and 0.18 μM, respectively as well as downstream effects of insulin on GLUT4 translocation (IC50 = 0.47 μM) and glucose transport (IC50 = 0.14 μM). In addition, treatment with MK-2206 causes a robust, concentration-depend ent activation of autophagy in human glioma cell lines LN229 and T98G.

A highly selective non-ATP competitive allosteric Akt inhibitor with IC50's of 8 nM, 2 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. MK-2206 potently inhibits phosphorylation of Thr³â°â¸ and Serâ´â·³ in 3T3-L1 adipocytes with IC50 values of 0.11 and 0.18 μM, respectively as well as downstream effects of insulin on GLUT4 translocation (IC50 = 0.47 μM) and glucose transport (IC50 = 0.14 μM). In addition, treatment with MK-2206 causes a robust, concentration-dependent activation of autophagy in human glioma cell lines LN229 and T98G.

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Technical Specifications

  A.G. Scientific, Inc.
Product Category Biological Materials
Product Number M-2382
Product Name MK-2206
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