Inhibits Stat3.Stat3 complex formation and Stat3-DNA binding activity in vitro (IC50 = 86 &plusm; 33 μM) and Stat3-dependent transcriptional activities. S3I-201 inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin and inhibits the growth of human breast tumors in vivo.
| A.G. Scientific, Inc. | |
|---|---|
| Product Category | Biological Materials |
| Product Number | S-2444 |
| Product Name | Stat3 Inhibitor I, S3I-201 |
