A.G. Scientific, Inc. Ro 31-8220 methanesulfonate R-2418

Description
Cell-permeable. A potent bisindolylmaleimide inhibitor of protein kinase C (PKC) isoforms (IC50 = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-î³, and PKC-îµ, respectively). It inhibits protein kinase A (PKA) (IC50 = 0.9 μM) and calcium/calmodulin kinase II (IC50 = 17 μM) at much higher concentrations. Also inhibits glycogen synthase kinase-3 (GSK-3) (IC50 = 6.8 nM).
Description
Cell-permeable. A potent bisindolylmaleimide inhibitor of protein kinase C (PKC) isoforms (IC50 = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-î³, and PKC-îµ, respectively). It inhibits protein kinase A (PKA) (IC50 = 0.9 μM) and calcium/calmodulin kinase II (IC50 = 17 μM) at much higher concentrations. Also inhibits glycogen synthase kinase-3 (GSK-3) (IC50 = 6.8 nM).

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A.G. Scientific, Inc.
San Diego, CA, USA
Ro 31-8220 methanesulfonate
R-2418
Ro 31-8220 methanesulfonate R-2418
Cell-permeable. A potent bisindolylmaleimide inhibitor of protein kinase C (PKC) isoforms (IC50 = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-î³, and PKC-îµ, respectively). It inhibits protein kinase A (PKA) (IC50 = 0.9 μM) and calcium/calmodulin kinase II (IC50 = 17 μM) at much higher concentrations. Also inhibits glycogen synthase kinase-3 (GSK-3) (IC50 = 6.8 nM).

Cell-permeable. A potent bisindolylmaleimide inhibitor of protein kinase C (PKC) isoforms (IC50 = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively). It inhibits protein kinase A (PKA) (IC50 = 0.9 μM) and calcium/calmodulin kinase II (IC50 = 17 μM) at much higher concentrations. Also inhibits glycogen synthase kinase-3 (GSK-3) (IC50 = 6.8 nM).

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Technical Specifications

  A.G. Scientific, Inc.
Product Category Biological Materials
Product Number R-2418
Product Name Ro 31-8220 methanesulfonate
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