A.G. Scientific, Inc. Necrostatin-5 N-1229

Description
Inhibits non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5 A. Degterev, et al.; Nat. Chem. Biol. 4, 313 (2008).
Description
Inhibits non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5 A. Degterev, et al.; Nat. Chem. Biol. 4, 313 (2008).

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A.G. Scientific, Inc.
San Diego, CA, USA
Necrostatin-5
N-1229
Necrostatin-5 N-1229
Inhibits non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5 A. Degterev, et al.; Nat. Chem. Biol. 4, 313 (2008).

Inhibits non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5
A. Degterev, et al.; Nat. Chem. Biol. 4, 313 (2008).

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Technical Specifications

  A.G. Scientific, Inc.
Product Category Biological Materials
Product Number N-1229
Product Name Necrostatin-5
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