A.G. Scientific, Inc. UNC0638 U-2473

Description
Cell-permeable. UNC0638 is a potent G9a HMTase inhibitor, exhibiting an IC50 value of 50 value of 19 nM, but is more than 10,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and SUV39H2. UNC0638 inhibits H3K9 dimethylation in MDA-MB231 cells with an IC50 value of 81 nM and demonstrates favorable separation of functional and toxic effect.
Description
Cell-permeable. UNC0638 is a potent G9a HMTase inhibitor, exhibiting an IC50 value of 50 value of 19 nM, but is more than 10,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and SUV39H2. UNC0638 inhibits H3K9 dimethylation in MDA-MB231 cells with an IC50 value of 81 nM and demonstrates favorable separation of functional and toxic effect.

Suppliers

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Product
Description
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A.G. Scientific, Inc.
San Diego, CA, USA
UNC0638
U-2473
UNC0638 U-2473
Cell-permeable. UNC0638 is a potent G9a HMTase inhibitor, exhibiting an IC50 value of 50 value of 19 nM, but is more than 10,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and SUV39H2. UNC0638 inhibits H3K9 dimethylation in MDA-MB231 cells with an IC50 value of 81 nM and demonstrates favorable separation of functional and toxic effect.

Cell-permeable. UNC0638 is a potent G9a HMTase inhibitor, exhibiting an IC50 value of 50 value of 19 nM, but is more than 10,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and SUV39H2. UNC0638 inhibits H3K9 dimethylation in MDA-MB231 cells with an IC50 value of 81 nM and demonstrates favorable separation of functional and toxic effect.

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Technical Specifications

  A.G. Scientific, Inc.
Product Category Biological Materials
Product Number U-2473
Product Name UNC0638
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