A.G. Scientific, Inc. Splitomicin S-2441

Description
Potent inhibitor of yeast NADâº-dependent histone deacetylase Sir2p (IC50 = 60 μM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.
Description
Potent inhibitor of yeast NADâº-dependent histone deacetylase Sir2p (IC50 = 60 μM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.

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Company
Product
Description
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A.G. Scientific, Inc.
San Diego, CA, USA
Splitomicin
S-2441
Splitomicin S-2441
Potent inhibitor of yeast NADâº-dependent histone deacetylase Sir2p (IC50 = 60 μM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.

Potent inhibitor of yeast NADâº-dependent histone deacetylase Sir2p (IC50 = 60 μM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.

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Technical Specifications

  A.G. Scientific, Inc.
Product Category Biological Materials
Product Number S-2441
Product Name Splitomicin
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