A.G. Scientific, Inc. Datasheets for Biological Materials
Biological materials are biocompatible materials, natural or man-made, that comprise a whole or a part of a living structure or biomedical device that performs, augments, or replaces a natural function
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| Product Name | Notes |
|---|---|
| ** INQUIRE for lead time from stock *** Active enzyme purified from E. coli. The rate of caspase enzymatic hydrolysis can be measured by release of AMC from the Ac-DEVD-AMC... | |
| ** Inquire for price and availability. | |
| **Inquire for availability. Used to screen caspase inhibitors, study enzyme regulation, determine caspase substrate specificity, or as positive control in caspase activity assays. Produced from E.coli. ~25,000U/mg protein. Recommend 1U... | |
| 17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90). Hsp90 is a protein chaperone that binds to signaling... | |
| A 0.5 M solution of ethylenediaminetetra acetic acid disodium (EDTA) in water (pH 8.0). | |
| A 10 mM ( 1 mg in 221 μl) of Pyrintegrin (Cat. No. 1729-1) in anhydrous DMSO. | |
| A 10 mM (1 mg in 190 μl) solution of the negative control Q-VE-OPh (Cat. No, 1171-1) for the caspase inhibitor Q-VD-OPh (Cat. No. 1170-1) in DMSO. | |
| A 10 mM (1 mg in 195 μl) solution of caspase inhibitor Q-VD-OPh (Cat. No, 1170-1) in DMSO. | |
| A 10 mM (1 mg in 209 μl) solution of PD184352 (Cat. No. 1585-1) in anhydrous DMSO. | |
| A 10 mM (1 mg in 260 μl) solution of SB-431542 (Cat. No. 1674-1) in anhydrous DMSO. | |
| A 10 mM (5 mg in 1051 μl) solution of MG-132 (Cat. No.1703-5) in anhydrous DMSO. | |
| A 10 mM (5 mg in 1075 μl) solution of CHIR99021 (Cat. No. 1677-5) in anhydrous DMSO. | |
| A 10 mM (5 mg in 1870 μl) solution of PD98059 (Cat. No. 1666-5) in anhydrous DMSO. | |
| A 10 mM (5 mg/1627 μl) solution of PI -3 Kinase inhibitor LY 294002 (Cat. No.1667-5) in DMSO. | |
| A 10 mM (500 μg in 132 μl) solution of Gö 6976 (Cat. No. 1711-500) in anhydrous DMSO. | |
| A 100 mM (25 mg in 469.4 μl) solution of Sunitinib Malate (Cat. No. 1611-25) in anhydrous DMSO. | |
| A 100 mM (25 mg in 538.1 μl) solution of Tozasertib (Cat. No. 1595-25) in anhydrous DMSO. | |
| A 100 mM solution of ATP in de-ionized water. | |
| A 2% solution of AEC in DMF | |
| A benzimidazole analog that acts as a potent and selective IKK-ε kinase inhibitor (IC50 ~15.8 μM). | |
| A benzimidazole analog that acts as a potent and selective inhibitor of IKK-ε kinase (IC50 = 40 nM); displays >125-fold selectivity over IKK-α and IKK-β. | |
| A benzoquinoid ansamycin antibiotic that acts as a cell permeable inhibitor of tyrosine kinase and inducer of Heat Shock Proteins. Hsp90 inhibitor. Demonstrates anti-angiogenesis activity. | |
| A biological antioxidant that helps protect cells from reactive oxygen species such as free radicals and peroxides. Glutathione is nucleophilic at sulfur and attacks poisonous electrophilic conjugate acceptors. | |
| A biotinylated derivative of the tetrapeptide inhibitor ASTD-FMK, which acts as a competitive inhibitor for the cleavage site of pro-EMAP II (Endothelial monocyte-activating polypeptide). EMAPII, which is a proinflammatory cytokine... | |
| A bisperoxovanadium compound that acts as a potent protein phosphotyrosine phosphatase (PTP) inhibitor as well as an insulin receptor kinase (IRK) activator. Also a potent PTEN inhibitor (IC50 = 31... | |
| A bisperoxovanadium compound that acts as a potent protein phosphotyrosine phosphatase (PTP) inhibitor as well as an insulin receptor kinase (IRK) activator. Also an excellent insulin mimetic in vitro and... | |
| A bitter-tasting crystalline alkaloid,derived from ipecac root and used in the treatment of amebiasis and as an emetic.Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. | |
| A Ca2+ slow channel agonist. | |
| A cell permeable potent and selective inhibitor of protein kinase C (IC50 = 87 nM) and protein kinase A (IC50 = 2.7 μM). Refer to G-1063 for Bisindolylmaleimide I. | |
| A cell permeable, potent, selective, inhibitor of protein kinases (PKA, Ki=48nM, and PKG) and protein kinase Cμ (PKCμ). Also inhibits Ca2+/calmodulin-depe ndent protein kinase II, casein kinase I and myosin... | |
| A cell- permeable activator of AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. In vivo, pharmacologic activation of AMPK with AICAR mimics... | |
| A cell-permeable Ca2⺠antagonist and vasodilator. Inhibits protein kinase A (Ki = 1.6 μM), protein kinase G (Ki = 1.6 μM), myosin light chain kinase (Ki = 36... | |
| A cell-permeable cAMP analog that is more resistant to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells. | |
| A cell-permeable cGMP analog having greater resistance to hydrolysis by phosphodiesterases than cGMP. Activates cGMP-dependent protein kinase (PKG), slows or inhibits the intracellular calcium oscillations of tracheal smooth muscle cells... | |
| A cell-permeable compound that acts as a selective, potent , and reversible inhibitor of non-moscule myosin II. Inhibits the ATPase and gliding motility of human platelets (≤100μM) whithout affecting myosin... | |
| A cell-permeable indole derivative that acts as an antioxidant and mitochondrial metabolism modifier. IPAM binds to the rate-limiting component of oxidative phosphorylation in complex I of the respiratory chain and... | |
| A cell-permeable negative control compound for protein kinase C inhibition studies (IC50 >100 μM). Blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k in vivo (IC50 8 μM). Refer to G-1063... | |
| A cell-permeable potent inhibitor of Raf kinase inhibitor protein (RKIP) with Raf1 kinase interaction. Blocks eukaryotic cell migration (ICâ‚…â‚€ = 14 μM for inhibition of wound closure in MDCK cell... | |
| A cell-permeable, ATP-competitive inhibitor of casein kinase 1 (CK1) (IC50 = 0.3 μM). Also inhibits ALK5 (IC50 = 0.5 μM) and p38É'MAP kinase (IC50 = 12 μM). Displays selectivity over... | |
| A cell-permeable, potent, and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC50 = 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and... | |
| A chemotherapy drug used in the treatment of hematological malignancies. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This... | |
| A convenient set consisting of eight Receptor Tyrosine Kinase (RTK) inhibitors. The eight inhibitors are: 5 mg of Axitinib (Cat. No. 1581-5), 5 mg of Canertinib (Cat. No. 1617-5), 5... | |
| A convenient set consisting of five Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase (TK) inhibitors. The five inhibitors are: 5 mg of Canertinib (Cat. No. 1617-5), 100 mg of Erlotinib,... | |
| A convenient set consisting of five Hedgehog (Hh) signaling pathway inhibitors and a negative control. The five inhibitors are: 50 μg of Cyclopamine-KAAD (Cat. No. 1910-50), 5 mg of GANT58... | |
| A convenient set consisting of five phosphoinositide 3-kinase (PI 3-kinase) inhibitors. The five inhibitors are: 1 mg of IC87114 (Cat. No. 1661-1), 5 mg of LY-294002 (Cat. No. 1667-5), 1... | |
| A convenient set containing eight ready-to-use capase family inhibitors. The set contains 25 μl (2 mM in DMSO) each of the following five inhibitors: Caspase-1 Inhibitor, Z-YVAD(OMe)-FMK; Caspase-2 Inhibitor, Z-VD(OMe)-VAD(OMe)-F... | |
| A convenient set containing five ready-to-use capase family inhibitors. The set contains 25 μl (2 mM in DMSO) each of the following five inhibitors: Caspase-1 Inhibitor, Z-YVAD(OMe)-FMK; Caspase-3 Inhibitor, Z-D(OMe)-E(OMe)-VD(O... | |
| A convenient set containing seven ready-to-use capase family inhibitors. The set contains 25 μl (2 mM in DMSO) each of the following five inhibitors: Caspase-1 Inhibitor, Z-YVAD(OMe)-FMK; Caspase-2 Inhibitor, Z-VD(OMe)-VAD(OMe)-F... | |
| A convenient set containing twelve ready-to-use capase family inhibitors. The set contains 25 μl (2 mM in DMSO) each of the following five inhibitors: Caspase-1 Inhibitor, Z-YVAD(OMe)-FMK; Caspase-2 Inhibitor, Z-VD(OMe)-VAD(OMe)-F... | |
| A convenient set of selected individual HDAC (Histone Deacetylase) inhibitors containing the following six: 1 mg of Apicidin (Cat. No. 1601-1), 1 mg of M344 (Cat. No. 1607-1), 100 mg... | |
| A derivative of the macrolide Rapamycin (Cat. No. 1568-5, 50) that acts as an immunosuppressant, mTOR inhibitor and anticancer agent. It targets the raptor mammalian target of rapamycin (mTORC1). | |
| A DNA topoisomerase I inhibitor. It induces apoptosis in human breast cancer cells. Inquire for pricing and lead time. | |
| A fluorogenic substrate for histone deacetylase (HDAC). Ex(max): 330nm; Em(max): 395nm. | |
| A fungal metabolite that acts as a microtubule inhibitor. Also induces cellular DNA Fragmentation. | |
| A fungal metabolite that acts as a potent inhibitor of actin filament and contractile microfilaments. Also see Cytochalasin A, B, D, or E | |
| A general protein kinase inhibitor. CaM (Ki=1.8 nM), PKA (Ki=25 nM), PKC (Ki=25 nM), PKG (Ki=20 nM), myosin light chain kinase (Ki=17 nM). | |
| A heparin-binding peptide derived from bone sialoprotein. Surfaces displaying this peptide support human embryonic stem (hES) cell adhesion and self-renewal. | |
| A heparin-binding peptide derived from fibronectin. Surfaces displaying this peptide support human embryonic stem (hES) cell adhesion and self-renewal. | |
| A heparin-binding peptide derived from vitronectin. Surfaces displaying this peptide support human embryonic stem (hES) cell adhesion and self-renewal. | |
| A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Useful in distinguishing among different types of ATPases. Seeking published researchers utilizing our Bafilomycin A1 product? Hit the... | |
| A MAP Kinase inhibitor; and a selective inhibitor of CK2. Chemopreventive and anti-tumor properties - inhibits proliferation of malignant tumor cells by G2/M arrest. Apoptosis inducer. Inquire for availability of... | |
| A membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP3) receptor antagonist (IC50 = 42 μM). | |
| A negative control for the PI(3)K inhibitor LY294,002. Does not inhibit PI(3)K even to concentrations >=100 μM (LY294002: IC50-1.4 μM). | |
| A Nitric Oxide donor, useful for reliable generation of Nitric Oxide (NO) in vitro or in vivo. | |
| A non-detergent sulfobetaine. Zwitterionic over a wide pH range. Easily removed by dialysis. | |
| A non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. Also acts as an... | |
| A nucleoside analog of deoxycytidine used in chemotherapy to treat various types of cancer. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidin e di- and triphosphate (dFdCDP, dFdCTP). dFdCDP... | |
| A plant lectin that is a T cell mitogen. Induces apoptosis in human fibroblasts. Induces autophagy. | |
| A platinum coordination complex with potent anti-neoplastic activity. | |
| A polyene anti-fungal antibiotic that non-specifically induces loss of low molecular weight substances from cells. Binds to sterols and disrupts osmotic integrity of fungal membrane. | |
| A potent and highly selective inhibitor of glycerine synthase kinase-3β (GSK-2β) (IC50 =6.7 nM). CHIR99021 has been shown to allow for long-term expansion of murine embryonic stem cells in a... | |
| A potent and irreversible inhibitor of Urokinase, Factor VIIa, Factor IXa, Factor Xa, and trypsin. | |
| A potent and selective allosteric inhibitor of the MEK1 (IC50 = 0.7 nM) and MEK2 (IC50 = 0.9 nM) enzymes with potential antineoplastic activity. | |
| A potent and selective inhibitor of Protein Kinase A (Ki=56 nM). | |
| A potent and specific Aurora kinase B inhibitor. It is 1000-fold more selective for aurora kinase B than for aurora kinase A ( Ki values of 1300 nM and 0.36... | |
| A potent and specific inhibitor of ERK2. Also adenosine kinase inhibitor. | |
| A potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; ICâ‚…â‚€=6 pM). | |
| A potent and specific inhibitor of the tyrosine kinase activity of the epidermial growth factor receptor (EGFR). IC50=25 pM. | |
| A potent growth inhibitor and cytotoxic agent; a potent DNA methyltransferase inhibitor. Causes DNA demethylation or hemi-demethylation, creating openings that allow transcription factors to bind to DNA and reactivate tumor... | |
| A potent inducer of apoptosis in numerous tumor cell lines. Also utilized for protein isoprenylation. Bulk available, inquire for pricing | |
| A potent inhibitor of endothelial Nitric Oxide Synthase (eNOS). Shown to be 5 times more potent inhibitor of endothelial cell NO synthase than L-NAME and L-NMMA. Non-sterile. Updated product specifications... | |
| A potent inhibitor of GSK-3β (Glycogen synthase kinase-3β) (IC50 = 30 nM). At 400 nM, TWS119 induces neurogenesis in murine embryonic stem cells making it a useful tool to regulate... | |
| A potent inhibitor of rat cerebellar Nitric Oxide Synthase (NOS). More potent inhibitor than 7-nitroindazole. | |
| A potent Inositol-1,4,5-trisp hosphate (IP3) receptor agonist. 10 times more potent than IP3. | |
| A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC50 values of 4.4,... | |
| A potent reversible inhibitor of mitochondrial oxidative phosphorylation. Depolarises mitochondrial membrane potential and induces apoptosis. | |
| A potent, ATP-competitive and selective Syk (Spleen tyrosine kinase) inhibitor (IC50 = 41 nM). Inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell... | |
| A potent, brain-penetrant, and water-soluble poly(ADP-ribose) polymerase (PARP) inhibitor. IC50 values are 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively. Neuroprotective in vitro and in vivo. | |
| A potent, cell permeable and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both... | |
| A potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM).That also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite... | |
| A potent, cell-permeable, and irreversible inhibitor of calpain II (k2 = 28,900 M⻹s⻹). Also acts as an inhibitor of cathepsin L (k2= 680,000 M⻹s⻹). | |
| A potent, cell-permeable, and irreversible inhibitor of Cathepsin B and L. | |
| A potent, irreversible inhibitor of human leukocyte elastase (HLE) (Ki = 10 μM). | |
| A potent, irreversible inhibitor of human neutrophil elastase (HNE). The structure of the enzyme-inhibitor complex reveals crosslinking of the catalytic residues His-57 and Ser-195 by the peptidyl chloromethylketone. | |
| A potent, selective and ATP-competitive inhibitor of ATM Kinase (Ki = 2.2 nM; IC50 = 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations... | |
| A Potent, selective and irreversible PPARÉ£ antagonist. Blocks the PPARÉ£-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 μM. | |
| A potent, selective, reversible, and slow binding dipeptidyl peptidase IV inhibitor (IC50 = 14 nM). Displays >15,000 fold selectivity over DPP-II and a range of Proline-cleaving proteases. Displays anti-diabetic activity... | |
| A potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G (IC50 = 53 nM and Ki = 63 nM). Acts as a weak inhibitor of chymotrypsin (Ki = 1.5 μM),... | |
| A pre-prodrug of 5-fluorouracil (5-FU). After oral uptake, capecitabine is first metabolized to 5'-deoxy-5-fluorocyt idine (5'-DFCR), which occurs mainly in the liver by carboxyl-esterase. The metabolite is converted to 5'-deoxy-5-fluoro-ur... | |
| A reported substrate for members of caspase family proteases | |
| A selective agonist for PPARδ (peroxisome proliferator-activat ed receptorδ) (EC50 = 1. 1 nM), displaying 1000-fold selectivity over the other human subtypes. In macrophages, fibroblasts, and intestinal cells, GW501516 increases... | |
| A selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). | |
| A semi-synthetic derivate of Geldanamcyin, 17-DMAG binds to Hsp90 and alters its function. A water soluble & cell-permeable analog of Geldanamycin (G-1047) and 17-AAG (A-1256), 17-DMAG binds to the APTase... | |
| A slow-releasing, water-soluble hydrogen sulfide (H2S) donor. Displays vasodilator and antihypertensive activity in rats in both acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Inhibits LPS-induced release of various proinflammatory... | |
| A small-molecule inhibitor of the mammalian target of rapamycin (mTOR). Blocking mTOR creates a starvation-like effect in cancer cells by interfering with cell growth, division, metabolism, and angiogenesis. | |
| A small-molecule, ATP-competitive inhibitor of cFMS kinase; at 60 nM it inhibits human cFMS kinase completely in vitro and was inactive against 26 other kinases. GW2580 also inhibits lipopolysaccharide (LPS)-induced... | |
| A specific, ATP-competitive, small-molecule inhibitor of the receptor tyrosine kinases (RTKs) c-Met and anaplastic lymphoma kinase (ALK). Iinhibits tyrosine phosphorylation of activated ALK at nanomolar concentrations. Inhibits the growth and... | |
| A specific, small molecule inhibitor of SREBP (Sterol Regulatory Element-Binding Proteins). Betulin decreases lipid levels, enhances insulin sensitivity, and reduces the development of atherosclerotic plaques. Betulin can serve as a... | |
| A structurally unique marine natural product that binds to and activates PKC at picomolar concentrations, but is not a carcinogen or a complete tumor promoter. In many systems it induces... | |
| A styrylquinazoline derivative that acts as a p53 stabilizing agent. It not only restores p53 functions in mutant p53-expressing cells but can also significantly increase the protein level and promote... | |
| A suicide inhibitor of cytochrome P-450 and chloroperoxidase. Inhibits oxidative drug metabolism in vivo. New sizes for 2011, Also available in bulk gram quantities, inquire for pricing. | |
| A synthetic derivative of coelenterazine. Generates 15 times great luminescence, and has a faster response time to calcium, than native coelenterazine does. | |
| A synthetic peptide inhibitor that inhibits caspase-10 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The... | |
| A synthetic peptide inhibitor that inhibits caspase-13 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The... | |
| A synthetic peptide inhibitor that inhibits caspase-4 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The... | |
| A synthetic peptide inhibitor that irreversibly inhibits caspase-3 and related protease/caspase activity and blocks apoptosis. DEVD is the specific recognition sequence found in poly (ADP-ribose) polymerase (PARP). The inhibitor is... | |
| A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to enhance cell permeability. The conjugation with biotin... | |
| A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be... | |
| A synthetic peptide that irreversibly inhibits activity of caspase-3 and related caspases and blocks apoptosis. The inhibitor is designed as a methyl ester to enhance cell permeability. The conjugation with... | |
| A synthetic peptide that irreversibly inhibits activity of caspase-8 and related caspases and blocks apoptosis. The inhibitor is designed as a methyl ester to enhance cell permeability. The conjugation with... | |
| A synthetic peptide that irreversibly inhibits caspase-12 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on... | |
| A synthetic peptide that irreversibly inhibits caspase-2 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on... | |
| A synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on... | |
| A synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on... | |
| A synthetic peptide that irreversibly inhibits EMAP II (Endothelial Monocyte-Activated Polypeptide II) activity released during apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If... | |
| A synthetic peptide that irreversibly inhibits FLICE and related protease/caspase activity and blocks apoptosis. IETD is the specific recognition sequence found in CPP32 proenzyme. The inhibitor is designed as a... | |
| A synthetic peptide that irreversibly inhibits ICE (interleukin-1β converting enzyme, Ki = 0.76 nM) activity. YVAD is the specific recognition sequence for ICE/caspase-1. The inhibitor is designed as a methyl... | |
| A synthetic peptide that irreversibly inhibits ICE-family protease/caspase activity and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is... | |
| A topoisomerase II inhibitor. A derivative of podophyllotoxin that has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis... | |
| A useful fluorogenic substrate for neutrophil elastase. Cleavage of this peptide by the enzyme generates a strongly fluorescent AFC that is monitored fluorometrically. λex: 380 nm; λem: 500 nm. | |
| A vasodilator and hypotensive agent. Activates adenylate cyclase leading to an increase in the intracellular concentration of cAMP. | |
| A very active antibiotic against many yeasts and fungi. Inhibits protein synthesis in eukaryotes (but not in prokaryotes) by interfering with the translocation step. It inhibits chain initiation as well... | |
| A very potent protein kinase C (PKC) inhibitor with high selectivity for the PKC isotypes (α, β, y). Potent antagonist of HIV-1 induction. Attached is a published references from researchers... | |
| A water soluble and stable nitric oxide scavenger; shows antagonistic action against the free nitric oxide radical (NO). Almost a 2-fold stronger inhibitory effect than those of NMMA or NOARG. | |
| ABT-869 is multi-targeted inhibitor of all members of the VEGF and PDGF receptor families (e.g., KDR, IC50 value of 4 nM), but has much less activity (IC50 values >1 μM)... | |
| ABTS is considered a safe and sensitive substrate compatible for horseradish peroxidase (HRP) based ELISA assays. In the presence of hydrogen peroxide and HRP, ABTS is oxidized to a radical... | |
| Acetomycin | |
| Actinopyrone A is a γ-pyrone compound isolated from a Streptomyces sp. It has selective (>106 fold) and potent (MIC 0.0001 μg/ml) activity against Helicobacter pylori, the principle cause of peptic... | |
| Activator of cannabinoid and vanilloid receptors. Demonstrates anti-proliferative activity in breast cancer. | |
| Acts as a potent and selective inhibitor of protein phosphatase 2A. Also inhibits protein phosphatase 1 at higher concentrations. Useful in inhibition of PP1 and PP2A during purification of phosphorylated... | |
| Adriamycin is the most extensively studied of a family of highly fluorescent anthracycline antibiotics produced by several Streptomyces species, first reported in 1967 and later approved for human therapeutic use... | |
| AEBSF.HCl is a specific irreversible inhibitor of serine proteases, such as thrombin, plasmin, kallikrein, chymotrypsin, and trypsin. AEBSF.HCl is a non-toxic alternative to PMSF. AEBSF is affected by both pH... | |
| AG 1478 | |
| AG 527 | |
| AG 82 | |
| Agistatin B | |
| Agistatin D | |
| Agistatin E | |
| Alternariol, Alternaria sp. | CAS [641-38-3] | A.G. Scientific, Inc | |
| Aminoglycoside used as a selective agent of transfected mammalian, yeast, plant and bacteria cells. Resistance is conferred by the bacterial gene for aminoglycoside-3'-ph ophotransferase that can be expressed in eukaryotic... | |
| AMPA (2-amino-3-(5-methyl -3-oxo-1,2- oxazol-4-yl)propanoi c acid) is a compound that is a specific agonist for the AMPA receptor, where it mimics the effects of the neurotransmitter glutamate. There are two... | |
| An acyclic analog of the nucleoside guanosine, chemically related to acyclovir. It inhibits the replication of viruses including CMV, Herpes Simplex, Varicella Zoster and Epstein-Barr. It inhibits virus replication by... | |
| An aminoglycosidic antibiotic. Used for the selection and maintenance of pro- and eukaryotic cells transfected with the E. coli hygromycin resistance gene. Inquire for other sizes & bulk pricing. Additional... | |
| An analog of Cisplatin with reduced nephrotoxicity. Displays potent anti-tumor activity. | |
| An anti-inflammatory glucocorticoid. Inhibits the expression of the inducible but not the constitutive nitric oxide synthase in vascular endothelial cells (IC50 = 5 nM). Enhances active cation transport in aortic... | |
| An anti-neoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent... | |
| An Antibiotic displaying antibacterial and anti-tumor activity. | |
| An anticancer agent. This is a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxyca mptothecin (SN-38), a potent inhibitor of DNA topoisomerase I. | |
| An antimalarial drug. Inhibits autophagy of glioma cells via a mechanism distinct from that of 3-Methyladenine. | |
| An effective Glutathione S-transferase(GST) inhibitor at 2-100 μM | |
| An epigenetic modifier. Decitabine is an analogue of the nucleoside 2'-deoxycytidine. It is believed to exert its antineoplastic effects after phosphorylation and direct incorporation into DNA and inhibition of DNA... | |
| An excellent buffer in the pH range of 6.2-7.8. Imidazole has a pKa of 7.0 at 20°C. | |
| An imidazopyridine derivative that acts as a potent downstream antagonist of Hedgehog(Hh) signaling pathway. JK184 functions by inhibiting class IV alcohol dehydrogenase (Aldh7) (IC50 = 210 nM). | |
| An inhibitor of NAD-dependent deacetylase activity of human SIRT1 (IC50 = 56 μM) and SIRT2(IC50 = 59 μM). Acts as an antitumor agent. Treatment of BCL6-expressing Burkitt lymphoma cells with... | |
| An inhibitor of soluble guanylate cyclase. Inhibits nitric oxide induced smooth muscle relaxation. | |
| An inhibitor of the bcr-abl tyrosine kinase. It acts by binding to the ATP binding site of bcr-abl. Imatinib also stimulates the entry of the bcr-abl tyrosine kinase into the... | |
| An integrin ligand peptide derived from fibronectin and vitronectin. Surfaces displaying this peptide supports human embryonic stem (hES) cell adhesion but not self-renewal. | |
| An iron chelator used for the treatment of acute iron intoxication and of chronic iron overload due to transfusion-dependen t anemias. Has been shown to have anti-proliferative effects on vascular... | |
| An irreversible arginase inhibitor. | |
| An isoflavone glycoside found in soy-based products. Can be used as a negative control for the PTK inhibitor Genistein (Cat. No. 1533). | |
| An isoquinoline alkaloid that acts as an anticancer agent. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. It induces the most potent apoptosis in... | |
| An orally bioavailable pan-HER tyrosine kinase inhibitor with potential antineoplastic activity. BMS-599626 inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells... | |
| Analog of kenpaullone acting as a potent and ATP-competitive inhibitor of GSK-3β (IC50=18 nM). Displays ~100-200 fold greater selectivity on GSK-3Beta than over CDK1/cyclin B and CDK5/p25 (IC50=2.0 μM and... | |
| Anisomycin is a pyrrolidine antibiotic, that acts as an anti-fungal antibiotic which inhibits Protein Synthesis. Anisomycin also activates p54, MAP Kinases and Stress-Activated Protein Kinases. Anisomycin is used in Martin-Lewis... | |
| Anti-neoplastic antibiotic from streptomyces verticillus, mixture of Bleomycin A2, B2, B4. Bleomycin sulfate binds to DNA, and can inhibit DNA synthesis and causes scission of DNA. Cleaves DNA, requires binding... | |
| Antibiotic produced by Streptomyces grieus that inhibits RNA synthesis. Also used as a fluorescent dye to determine DNA concentrations. Other sizes & bulk quantities available, inquire for pricing. Seeking published... | |
| Antibiotic that demonstrates anti-bacterial action in vitro against a variety of gram-positive and a few gram-negative organisms. Inquire for other sizes and bulk pricing. | |
| Antibiotic that demonstrates anti-tumor activity. Also unique anti-bacterial agent. Inhibitor of leucine aminopeptidase. Actinonin, a Naturally Occurring Antibacterial Agent, Is a Potent Deformylase Inhibitor Dawn Z. Chen, Dinesh V. Patel,... | |
| Antibiotic which acts as an inhibitor of mammalian glucosidases I and II. 'LIKE US' ON FACEBOOK AND RECEIVE 10% OFF YOUR ENTIRE ORDER. CLICK BLUE ARROW. | |
| Antibiotic which is a specific inhibitor of vacuolar H+ ATPase. More potent & specific inhibitor than Bafilomycin A1. Inhibits the acidification of organelles including lysosomes and the Golgi apparatus. Reported... | |
| Antibiotic, which inhibits cell wall synthesis. Partial agonist at the glycine modulatory site of the NMDA receptor. Synthetically derived product. Bulk quantities available, inquire for pricing & lead time. | |
| Antibiotic. More hydrophobic analog of the antibiotic thiolutin with selective antitumor activity. Potent inhibitor of bacterial and yeast RNA polymerases and of fungal mannan and glucan formation. Anticancer propeties of... | |
| Antibiotic. Potent and specific inhibitor of mitochondrial complex II (succinate-ubiquinon e oxidoreductase). Synthetic, originally isolated from Penicillium sp strain FO-125. | |
| Antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Inhibitor of clathrin-coated pits (CCP) dependent endocytosis | |
| Antipsychotic with greater affinity for D4 dopamine receptor versus D2 or D3 dopamine receptors. | |
| Antiviral which also inhibits Protein Kinase C and to a lesser extent Casein Kinase II and MAP Kinase. | |
| Aphidicolin is a reversible Inhibitor of eukaryotic nuclear DNA replication. Aphidicolin blocks cell cycle at early S-phase. Attached is a published reference from researchers who have used our Aphidicolin product. | |
| Aprotinin is a trypsin inhibitor which inhibits kallikrein, trypsin, chymotrypsin, and various serine proteases. Aprotinin source is Bovine lungs sourced from licensed slaughterhouses in New Zealand. The lungs have passed... | |
| Ascomycin is an ethyl analog of FK506 with strong immunosuppressant properties. Acts by binding to immunophilins, especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 (interferon- and IL-2)... | |
| ATP-dependent K+ channel blocker in the pancreas, which in turn causes intracellular Ca2+ levels to rise and for insulin to be secreted. It blocks vascular smooth muscle relaxation produced by... | |
| Axitinib (also known as AG-013736) is a small molecule tyrosine kinase inhibitor. It inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, PDGFR, and cKIT (CD117). It has been shown to significantly... | |
| Based on the detection of AFC after cleavage from labeled substrate LEHD-AFC. | |
| Benzamidine is a reversible competitive inhibitor of trypsin, trypsin-like enzymes and serine proteases. As a general inhibitor it can be used at 1 mM. It is sensitive to oxidation and... | |
| Bestatin is an aminopeptidase inhibitor. Enclosed are a couple selected reviews involving Bestatin applications: http://www.fasebj.or g/content/7/2/290.fu ll.pdf+html http://physiologyonl ine.physiology.org/c ontent/25/6/364.full .pdf+html http://bloodjournal. hematologylibrary.or g/content/112/7/2628 .full.pdf+htmlhttp:/ /jas.fass.org/conten t/86/9/2135.full.pdf +html | |
| Beta-Lactamase, E.C.3.5.2.6, penicillin amido-beta-lactam hydrolase, isolated from the organism, Bacillus cereus 569/H9 Beta Lactamase is used to destroy/remove Beta-Lactam antibiotics. Has broad sprectrum of activity against both penicillins (penicillinase or... | |
| Bexarotene is a synthetic retinoid analog with specific affinity for the retinoid X receptor and belongs to a group of compounds called rexinoids. It is an oral, noncytotoxic drug that... | |
| BIBW-2992 is a potent irreversible EGFR/HER2 inhibitor. The potency of BIBW-2992 on the EGFR and HER2 kinases revealed IC50 values of 0.5 nM and 14 nM, respectively. BIBW-2992 is highly... | |
| Binds to human ST2. Activates human ST2-dependent NF-κB pathway. Does not activate mouse ST2-dependent NF-κB. Produced in E. coli. Untagged human IL-33 (aa 112-270). | |
| Binds to mouse and human ST2. Activates mouse and human ST2-dependent NF-κB pathway. Produced in E. coli. Untagged mouse IL-33 (aa 109-266). | |
| Biochem/physiol Actions Casein kinase II inhibitor. | |
| Biochem/physiol Actions EGFR protein tyrosine kinase inhibitor. **NOTE: product specifications updated for Chemical Formula and MW to reflect amended data. | |
| Biochem/physiol Actions EGFR protein tyrosine kinase inhibitor. | |
| Biochem/physiol Actions Receptor tyrosine kinase inhibitor. | |
| Biochem/physiol Actions Selective inhibitor of human p210 protein tyrosine kinase. | |
| Biochem/Physiol Actions Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor. | |
| Biological buffer with a useful pH range of 7.3-8.7. pKa=8.0 at 25°C. | |
| Biologically active form of Vitamin D3 in intestinal calcium transport and bone calcium reabsorption. Stimulates Osteoprotegerin. Product is available, inquire with A.G. Scientific to confirm pacakge size, formulation, & current... | |
| Blasticidin S.HCl is an inhibitor of DNA and protein synthesis. Blasticidin S is a peptidyl nuncleoside antibiotic isolated from the culture broth of Stretomyces girseochromogenes. Blasticidin S is used to... | |
| Borrelidin, an 18-membered macrolide-polyketide , is a compound with anti-viral, anti-bacterial, anti-malarial, and anti-angiogenic properties. It is a known inhibitor of bacterial and eukaryal threonyl-tRNA synthetases. Borrelidin induces apoptosis in... | |
| Bosutinib (SKI-606) is a novel tyrosine kinase inhibitor. Bosutinib can overcome not only Bcr-Abl-dependent mechanisms of resistance, but also those that are Bcr-Abl-independent. It is used to treat patients with... | |
| Broad spectrum, cell culture antibiotic that is non toxic to viruses and mammalian cells at antibacterial levels. It is useful for long-term virus and tissue culture studies. Inhibits protein synthesis... | |
| Carbohydrate which acts as a cyanogenic glycoside. Available, lead time: ~3- 5 days. Inquire for larger package sizes & bulk pricing. | |
| Carboxyl activating agent for the coupling of primary amines to yield amide bonds. | |
| Carrier of nitric oxide, relaxing smooth muscles and inhibiting platelet activation. | |
| Castanospermine is a Plant alkaloid. Potent inhibitor of alpha- and beta-glucosidase activity in fibroblast extracts; inhibits the glycoprotein processing cycle. Castanospermine exhibits antiviral properties and prevents angiogenesis. Inquire for bulk... | |
| Catharanthine is one of the alkaloids isolated from the plant Catharanthus roseus. It stimulates the release of amylase from pancreatic fragments and causes extensive degranulation of pancreatic acinar cells with... | |
| Causes release of calcium from intracellular stores. Inquire for pricing of other sizes available. | |
| Causes release of calcium from intracellular stores. Sodium Salt Form. | |
| Cediranib (AZD2171) is a tyrosine kinase inhibitor that targets vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3, c-KIT, and platelet-derived growth factor receptors. Studies show cediranib to be... | |
| Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits prostaglandin production. Celecoxib is approximately 7.6-fold more selective for COX-2 inhibition over COX-1. This specificity allows celecoxib to reduce inflammation... | |
| Cell culture tested. G418 Aminoglycoside used as a selective agent of transfected mammalian, yeast, plant and bacteria cells. G418 Resistance is conferred by the bacterial gene for aminoglycoside-3'-ph ophotransferase that... | |
| Cell permeable and irreversible inhibitor of caspase-6. | |
| Cell permeable derivative of calcein. Calcein-AM has been used in a functional assay to measure Pgp and MRP activities in acute myeloid leukemia patients | |
| Cell permeable derivative of Ins(3,4,5,6)P4. Inquire for lead time from stock & pricing for 2012 | |
| Cell permeable Fluorescent Ca2+ indicator. Hydrolysis by non-specific esterases traps the indicator in the cytosol. | |
| Cell permeable inhibitor of γ-secretase (IC50=115 nM for total β-amyloid, IC50=200 nM for β-amyloid 1-42). Does not inhibit presenilinase. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can... | |
| Cell permeable inhibitor of CDK1 (IC 50=1.1 μM) and CD2 (IC50=600 nM). Arrests cell cycle in the Gâ‚/S boundary and activates mature bovine oocytes. | |
| Cell permeable non-tubulin-interact ing mitosis inhibitor. Blocks mitosis (IC50=800nM) by binding to the mitotic kinesin Eg5. | |
| Cell permeable triazolo-diamine compound; displays anti-proliferative properties in human cancer cells (IC50=20nM, 35nM and 92nM in HCT-116, HeLa, and A375 cells). Acts as a highly potent, ATP-competitive inhibitor of CDK1/cyclin... | |
| Cell permeable, reversible and competitive inhibitor of CDK1/cyclin B (IC50=33 nM), CDK2/cyclin A (IC50=33 nM), CDK2/cyclin E (IC50=28 nM) and CDK5/p35 (IC50=20 nM). | |
| Cell permeable, very sensitive and specific chemiluminescence probe of the superoxide anion and peroxynitrite. Shows 20 times higher luminescence than coelenterazine. | |
| Cell permeable, very sensitive and specific chemiluminescence probe of the superoxide anion and peroxynitrite. When oxidized by oxygen it illuminates blue light at 446nm when Ca2+ binds to the complex. | |
| Cell permeable. A potent and selective inhibitor of the cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5. Inhibits cell cycle progression at the G1/S and G2/M transitions. BLI is an important... | |
| Cell- permeable. A potent, selective, reversible, and ATP-competitive p97 inhibitor. DBeQ blocks both ubiquitin-dependent and autophagic protein clearance pathways and rapidly promotes executioner caspases -3 and -7. | |
| Cell-permeable kinase inhibitor with a selectivity for Protein Kinase C (PKC). For HCl form, inquire. Attached is a published reference from researchers who have used our GF-109203X product. We respectfully... | |
| Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYKK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits... | |
| Cell-permeable. A 10 mM (1 mg in 321 μl) solution of Thiazovivin (Cat. No. 1681-1) in anhydrous DMSO. | |
| Cell-permeable. A highly potent, pan phosphoinositide 3-kinase (PI 3-K) family kinase inhibitor with biochemical Ki's of 0.019 nM (PI 3-Kâº), 0.13 nM (PI 3-Kβ), 0.024 nM (PI 3-Kδ), 0.06 nM... | |
| Cell-permeable. A histone deacetylase (HDAC) inhibitor (Ki values are 0.41, 0.75, >100 and >100 μM for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Displays significant antitumor activity in vitro and in... | |
| Cell-permeable. A Janus Kinase 3 (JAK3) inhibitor. Displays greater antiproliferative and pro-apoptotic activity against murine multipotent factor-dependent cell Patersen-erythropoie tin receptor (FDCP-EpoR) cells harboring JAK2(V617F) compared with JAK2(WT). | |
| Cell-permeable. A naturally occurring anthraquinone that displays a range of biological activities including anti-inflammatory, anti-tumor and neuroprotective effects. Acts as a potent p56lck tyrosine kinase inhibitor (IC50= 18.5 μM). | |
| Cell-permeable. A potent AMPK activator. Directly stimulates partially purified rat liver AMPK (EC50 = 0.8 μM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC550 = 3.2 μM). | |
| Cell-permeable. A potent and selective γ-secretase inhibitor (IC50 = 17 nM) .Displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of... | |
| Cell-permeable. A potent and selective inhibitor of ACC2 (Acetyl-CoA Carboxylase) (IC50 = 28 nM for hACC2 vs 210 nM for hACC1 in in vitro studies). | |
| Cell-permeable. A potent and selective inhibitor of Akt1/Akt2 activity (ICâ‚…â‚€ = 58 nM (Akt1), 210 nM (Akt2) and 2.12 μM (Akt3) in in vitro kinase assays). The inhibition appears to... | |
| Cell-permeable. A potent and specific protein arginine N-methyltransferase (PRMTs) inhibitor (IC50 = 8.8 μM for human PRMT1 and 3.0 μM for yeast Hmt1p ). Does not compete for the AdoMet... | |
| Cell-permeable. A potent antagonist of the Hedgehog (Hh) signaling pathway (IC50 = 70 nM). | |
| Cell-permeable. A potent inhibitor of MET, vascular endothelial growth factor receptor 2 (VEGFR2), and RET, with robust antiangiogenic, antitumor, and anti-invasive effects. | |
| Cell-permeable. A potent inhibitor of the β-catenin-responsive transcription (CRT) in the nucleus. iCRT5 inhibits Wnt responsive STF16 luciferase (STF16-Luc) with an IC50 of 18 nM. It acts by disrupting the... | |
| Cell-permeable. A potent protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases. In contrast to other p38 MAPK inhibitors (e.g., SB203580), doramapimod prevents... | |
| Cell-permeable. A potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC50 = 10 nM). Displays excellent selectivity against many other kinases including Btk, Fyn, Itk, Lyn and Src... | |
| Cell-permeable. A potent, ATP-competitive and selective inhibitor of PI 3-K isoform p110δ (IC50 = 60 nM). Inhibits p110α and p110β only at higher concentrations (>1 μM). IC87114 does not inhibit... | |
| Cell-permeable. A potent, competitive, and reversible antagonist of the orphan receptor GPR35 (Ki = 12.8 nM). Prevents the GPR35-mediated increase in ERK1/2 phosphorylation and β-arrestin recruitment induced by pamoic acid. | |
| Cell-permeable. A potent, selective, non-transition state and non-competitive inhibitor of γ-secretase (IC50 = 0.3 nM for total β-amyloid) and Notch processing. At higher concentrations (20-400 μM), only weakly affects the... | |
| Cell-permeable. A reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) (IC50 = 0.28 μM) that also targets mTOR (IC50 = 5. 3μM), but not PI 3-K in vitro. Induces... | |
| Cell-permeable. A reversible, noncompetitive inhibitor of dynamin that interferes in vitro with the GTPase activity of dynamin1, dynamin2, and Drp1, the mitochondrial dynamin, but not of other small GTPases. Dynasore... | |
| Cell-permeable. A reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor (Ki = 400 nM). Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases... | |
| Cell-permeable. A slow-release prodrug version of Ro 61-8048 (Cat. No. 1912-5, 25), an inhibitor of KMO (kynurenine 3-monoxygenase), the enzyme that controls the kynurenine pathway, long believed to be implicated... | |
| Cell-permeable. A synthetic derivative of the natural product Cyclopamine (Cat. No. 1578-5) that acts as a specific inhibitor of Smoothened (Smo) and Sonic hedgehog (Shh) intracellular signaling (IC50 = 20 nM in... | |
| Cell-permeable. A very potent poly(ADP-ribose) polymerase (PARP) inhibitor. | |
| Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC50 ~ 5 μM in SAG-stimulated... | |
| Cell-permeable. Acts as an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC50 = 27 nM) by inhibition of the O-acyltransferase Porcn. Porcn is a member of the... | |
| Cell-permeable. An analog of thalidomide that was originally found based on its ability to effectively inhibit tumor necrosis factor production. Lenalidomide is 50,000 times more potent than thalidomide in inhibiting... | |
| Cell-permeable. An anthracycline antitumor antibiotic. A stereoisomer of doxorubicin (Cat. No. 1527-5) that exhibits reduced cardiotoxicity. Its antitumor actions are mediated by targeting topoisomerase II. | |
| Cell-permeable. An antioxidant and dual inhibitor of 5-lipoxygenase (IC50 = 8 μM) and cyclooxygenase (COX) (IC50 = 52 μM). Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated... | |
| Cell-permeable. An Antioxidant, anti-inflammatory and immunosuppressive agent. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC50 = 40 nM for IL-1β and IL-1α, 80 nM for IL-6, 110 nM for... | |
| Cell-permeable. An immunosuppressive agent. Inhibits T and B cell responses in vivo. Inhibitor of tyrosine phosphorylation (tyrosine kinase inhibitor), of dihydroorotate dehydrogenase, an enzyme for de novo pyrimidine synthesis, of... | |
| Cell-permeable. ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK) (IC50's at 100 μM ATP: RSK1 = 31 nM, RSK2 = 24 nM, RSK3 = 18 nM,... | |
| Cell-permeable. FK-866 is a highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransf erase (NAMPT) (Ki = 0.4 nM), causing gradual NAD+ depletion. NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic... | |
| Cell-permeable. Induces differentiation of mouse embryonic stem cells (ESCs) into cardiomyocytes (EC50 = 100 nM). | |
| Cell-permeable. Maintains the undifferentiated state of embrryonic stem cells. By targeting the PR72/130 subunit of the Ser/Thr phosphatases PP2A, it prevents β -catenin from switching coactivator usage from CBP to... | |
| Cell-permeable. Topical immune response modifier that displays anti-angiogenic, anti-viral and anti-inflammatory properties. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway. | |
| CHAPS is a zwitterionic detergent that combines the features of bile salts and N-alkyl sulfobetaines. Can be easily removed from gels or protein solutions by dialysis across a membrane. CHAPS... | |
| Chromogenic substrate for caspase-1 with increased cell permeability. λ max of pNA is 400nm. Peptide content:70-90% | |
| Chromogenic substrate for caspase-1, -4 and -5. Most potent for caspase-1. λ max of pNA 400nm. Peptide content: 70-90% | |
| Chromogenic substrate for caspase-1. Peptide content: 75-95% | |
| Chrysomycin A is the major analogue in a complex of C-glycoside antitumor actives, isolated from Streptomyces. Chrysomycin A, with a vinyl group in the 8-position, is the most potent analogue... | |
| Ciglitizone displays antihyperglycemic activity in genetically obese C57 Bl/6 ob/ob mice, also selective PPARγ agonist (EC50=3 μM). | |
| Ciprofloxican is a fluoroquinolone antibacterial agent. Inhibits cell division, causes double-strand breaks in the bacterial chromosome. It is also a broad-spectrum antibiotic effective against Gram-positive, Gram-negative and anaerobic bacteria. Has... | |
| Citreoviridin binds to and inhibit mitochondrial ATPase, thereby uncoupling oxidative phosphorylation. Aurovertins are used as biochemical tools. | |
| Cochlioquinone B, the minor component of a bioactive pigment isolated from Bipolaris leersia, is an NADH-ubiquinone reductase inhibitor and a phytotoxic agent inhibiting root growth. It is closely related to... | |
| Coelenterazine n is reported to be a very useful low-sensitivity coelenterazine. Synthetic derivative, has the weakest luminescence intensity, of its aequorin complex, of coelenterazine analogs. Also slower response time to... | |
| Colistin Sulfate is an antibiotic effective against most gram-negative bacilli. Colistin is a key microbiological component in Colistin Oxolinic Acid Blood Agar utilized in the cultivation of Aminobacter aminovorans, Bacillus... | |
| Competitive inhibitor of human serum aminopeptidase A, as well as leucine aminopeptidase, tyrosine aminopeptidase. Does not inhibit aminopeptidase B. | |
| Cyclopamine is a steroidal alkaloid that blocks sonic hedgehog signaling. It demonstrates teratogenic properties, as well as, promising anti-tumor properties. | |
| Daptomycin is a novel antimicrobial agent used for the treatment of gram-positive infections. The compound has a distinctive mechanism of action that exerts its bactericidal activity by disrupting plasma membrane... | |
| Dasatinib is a multi-kinase inhibitor with potent activity against BCR - ABL kinase (IC50 50 = 0.2 - 1.1 nM). Dasatinib also inhibits Lyn (IC50 = 8.5 nM) and Src... | |
| Dipeptidyl peptidase IV inhibitor. Inhibits rat, canine, human and monkey enzymes with IC50 values of 3, 5, 8, and 8 nM respectively. Long-acting hypoglycemic agent. Beneficial as protein preservation &... | |
| Dithiodiketopiperazi ne inhibitor of HIF-1 formation by disrupting the binding of p300 to both HIF(Hypoxia-inducibl e Factor)-1alpha and HIF-2alpha. Inhibitor of tumor growth. Potent immunosuppressor (con A-induced (IC50=0.17ug/ml) and LPS-induced... | |
| Dopamine agonist. | |
| E-64 is an Irreversible, potent and highly selective inhibitor of cysteine proteases. Does not affect cysteine residues in other enzymes. Acts by forming a thioether bond with thiol of the... | |
| EDAC or WSC is a versatile modern coupling agent. It is an easily handled solid with high solubility in water (>200gl-1) and organic solvents such as dichloromethane, tetrahydrofuran and dimethylformamide. | |
| Effective inhibition of Glutathione S-transferase (GST) at the concentration of 2-20 μM. | |
| Endotixin Level: <0.1 ng/μg. Reconstitution instructions: Reconstitute in 5 mM Tris, pH 7.6 to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers. Background... | |
| Enniatins are a complex of depsipeptides produced by several Fusarium species. Typically, the complex contains 4 major components: A, A1, B and B1 together with minor amounts of enniatin C,... | |
| Enzastaurin (Enz) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC50 = ~6 nM). Enz suprpresses VEGF-induced angiogenesis in the rat corneal micropocket assay, decreases microvessel density,... | |
| Enzyme Concentration: >20 units/mg powder. Activity: >20-60 U/mg powder at 37°C. One unit is the amount of enzyme which generates 1 u mole of Hydrogen Peroxide per minute at 37°C,... | |
| Extremely potent and selective Histamine H3 antagonist. Effective as an anticonvulsant. Inquire for current pricing from stock. | |
| F-actin probe, cell permeable. Markedly enhances the rate of actin filament nucleation. Potent prostrate cancer tool. | |
| Fatty acid synthase (FAS) inhibitor reported to bind in equimolar ratio to b-keto-acyl-ACP synthase, thus inhibiting protein acylation. | |
| FITC labeled mammalian calmodulin. | |
| Fluorescent DNA Stain. Binds Single stranded DNA. Useful tool in determining apoptosis. Also available, Actinomycin D #A-1022 Seeking published researchers utilizing our 7-Amino-Actinomycin D product? Hit the hot link for... | |
| Fluorogenic substrate for caspase-1 and -5. Also a substrate for caspase-4. This fluorogenic caspase-1 substrate with an optimal tetrapeptide sequence is cleaved 50-fold more efficiently than Ac-YVAD-AMC (Prod. No.C-1009). Peptide... | |
| Fluorogenic substrate for caspase-3, with Km=9.7μM. C1127 is similar to Ac-DEVD-AMC (# C-1133) but the AFC fluorophore has a greater Stokes' shift upon cleavage. The peptide sequence is based on... | |
| Fluorogenic substrate for caspase-8 and granzyme B. Also substrate for caspase-10. Peptide content: 70-90% | |
| Fluorogenic substrate for MMP-2 and MMP-9. Excitation: 280 nm; emission 360 nm. | |
| For an effective isolation of a highly enriched mitochondrial fraction from the cytosol fraction of various mammalian cells including both apoptotic and nonapoptotic cells. The enriched mitochondrial and Cytosolic fractions... | |
| For detecting cytochrome c translocation from mitochondria into cytosol during apoptosis. The kit provides an easy-to-use procedure and reagents for separating a mitochondria-enriche d fraction from cytosol. Cytochrome c released... | |
| FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclari as well as a structural analog of sphingosine. It is a novel immune modulator... | |
| Fumagillin is an inhibitor of endothelial cell proliferation and angiogenesis. Fumagillin is also being investigated as potential treatment of intestinal microsporidiosis We investigated the role of fumagillin as a potential... | |
| Fungal metabolite with structure similar to Fumonisin B1, induces cancer. | |
| Fungal metabolite, which inhibits spingomyelin biosynthesis in neuronal cells. | |
| GDC-0449, Vismodegib is a potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. GDC-0449, Vismodegib inhibition of SMO renders the transcription factor GLI inactive, thus preventing... | |
| GDC-0941 is a potent inhibitor of p110α and p110δ (IC50 = 3 nM). It selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger... | |
| Geldanamycin is a benzoquinone ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. HSP90 client proteins play important roles in the regulation of the cell... | |
| Glutamate receptor antagonist. | |
| Glutathione (GSH)-depleting agent. | |
| GM6001, GM-6001 is a potent, cell-permeable, broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs); (Ki = 400 pM for MMP-1; Ki = 500 pM for MMP-2; Ki = 27 nM... | |
| Griseofulvin is a spirobenzofuran produced by a number of Penicillium species, first isolated in the 1930s by Raistrick's group. Griseofulvin is a selective intifungal agent used to treat skin infections... | |
| Highly selective ligand for the D4 dopamine receptor. | |
| Human rhinovirus 3C protease (HRV 3C Protease) is a cysteine protease that recognizes the cleavage site of Leu-Glu-Val-Leu-Phe- Gln-Gly-Pro, commonly referred to as the PreScission Site. It cleaves between Gln... | |
| Hygromycin B, an aminoglycosidic antibiotic produced by Streptomyces hygroscopicus, is used for the selection and maintenance of prokaryotic and eukaryotic cells transfected with the hygromycin resistance gene, hph. Hygromycin B... | |
| IM-54 is an indolylmaleimide derivative which, at 1 μM, inhibits necrotic cell death induced by H2O2 in promyelocytic leukemia HL-60 cells. It does not prevent etoposide-induced apoptosis and does not... | |
| Immunologically inactive. Does not bind to immunophilin. Potent inhibitor of tumor promoting phorbol esters. Potent inhibitor of Ca/calmodulin dependent EF-2 phosphorylation in vitro. Potent and selective antagonist of formyl peptide... | |
| Inactive negative control for D-myo-Inositol 1,4,5-trisphosphate | |
| Induces apoptosis, which is not prevented by the presence of bcl-2. Inhibits mitochondrial electron transport specifically between cytochromes b and c1. (Formerly product # H1046) | |
| Induces phosphorylation of Tie-2 in primary cultured human and mouse vascular endothelial cells. More potent than native Ang-1. The fibrinogen-like domain (aa 284-498) of human Ang-1 (angiopoietin-1) is fused at... | |
| Inhibitor of c-Src (IC50=0.43 μM) blocking downstream STAT3 signalling. Induces apoptosis in human cancer cells. | |
| Inhibitor of calpain I, calpain II, cathepsin B and cathepsin L. Inhibits activation-induced programmed cell death. Also inhibits the peptidase activity of the 20S proteasome. | |
| Inhibitor of caspase-8. Recommended use: prepare stock solution (20mM in high purity DMSO) & store 6-8 months. Use2ul stock solution to 1ml of culture medium containing cells. DMSO concentrations higher... | |
| Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC50=10.2 μM) and Raji cells (IC50=15.5 μM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver,... | |
| Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC50=17.5 μM) and Raji cells (IC50=2.8 μM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver,... | |
| Inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. C75 exhibits irreversible slow-binding biphasic inactivation of fatty acid sythase. | |
| Inhibitor of NGF receptor (pp140c-trk) autophosphorylation selectivity without inhibiting EGF or PDGF receptor phosphorlyation (IC50=10μM). | |
| Inhibitor of phosphoinositide-dep endentn kinase 1 (PDK1). Potent, reversible and ATP-competitive inhibitor of glycogen synthase kinase-3α/β (GSK-3α/β) (IC50 = 5nM). | |
| Inhibitor of platelet derived growth factor (PDGF) autophosphorylation and PDGF-induced mitogenesis. | |
| Inhibitor of the Hedgehog (Hh) signalling pathway. Blocks GLI function in the nucleus. | |
| Inhibitor of vacuolar-type H+-ATPase from Streptomyces griseus. Inquire for availability. | |
| Inhibits arachidonic acid uptake. Inhibitor of lipoxygenases, cyclooxygenase (COX), phospholipase A2 and cytochrome P450. Modulates Ca2+ entry into cells. Stimulates luteinizing hormone release from cultured pituitary cells. | |
| Inhibits phosphodiesterases: PDE 1, 2, 3, 4, 5. | |
| Iniparib | |
| Ins(1,3)P2 | |
| Ins(1,3,4,5,6)P5.K+ | |
| Ins(4,5)P2 | |
| Intermediate in the biosynthesis of nitric oxide from L-arginine. Also inhibits arginases. | |
| IPTG is utilized for the induction of expression from the lac promoter and derivates. IPTG, Dioxane-Free (isopropyl-β-d-thiog alactopyranoside), is an inducer of β-galactosidase activity in many bacteria. Functioning as a... | |
| Irreversible Inhibitor of Neutrophil and rat microglia elastase. Inhibits proteolytic activity of poliovirus and rhinovirus 2A proteinases. Primary target: elastase-like serine protease. Bulk quantities readily available. Cal toll free 1-877-452-9925... | |
| Irreversible, cell permeable broad-spectrum caspase inhibitor. Peptide content: 77-97% | |
| Irreversible, cell permeable inhibitor of caspase-1. Also reported to inhibit caspase-4. | |
| Irreversible, cell permeable inhibitor of caspase-3 and -7. | |
| iTransFect reagent is a liposome formulation developed for highly efficient transfection of Spodoptera frugiperda-derived insect cells (e.g., Sf9 or Sf21). iTransFect offers the following advantages: simple 30 minute protocol, minimal... | |
| Keyhole Limpet Hemocyanin (KLH), a copper-containing protein isolated from the mollusck, Megathura crenulata, is a potent immunoactivator commonly used as a carrier in the conjugation of peptides for antibody production. | |
| Kit consists of 25ug each of: coelenterazine, coelenterazine cp, coelenterazine f, coelenterazine fcp, coelenterazine h, coelenterazine hcp, coelenterazine i, coelenterazine ip, and coelenterazine n. | |
| Lapatinib is a potent inhibitor of EGFR kinase (Ki = 3 nM), ErbB-2 kinase (Ki = 13 nM), ErbB-4 kinase (Ki = 347 nM). Lapatinib can restore tamoxifen sensitivity in... | |
| Latrunculin B is an actin filament modulator. 10 to 100-fold more potent than cytochalasins. Where cytochalasin D induces dissolution of F-actin and stress fiber contraction in fibroblasts in culture, Latrunculin... | |
| Leptin, the product of the ob (obese) gene, is a 16kDa protein consisting of 146 amino acid residues. Leptin is produced in the adipose tissue, and is considered to play... | |
| Leupeptin is a reversible inhibitor of serine and cysteine proteases. Leupeptin often used for inhibition of plasmin, trypsin, papain, kallikrein and cathepsin B. Synthetic. Bulk quantities readily available, inquire. DOWNLOAD... | |
| Lignan derivative with anti-tumor activities. Down-regulates anti-apoptotic protein Bcl-XL. Potent inhibitor of HIV Type-I Integrase and DNA topoisomerase II. Shows phytoestrogenic activity and is an antagonist for platelet activating factor... | |
| Mammalian calmodulin isolated from porcine brain is suitable for applications requiring active pure calmodulin. | |
| Mammalian calmodulin labeled with NHS ester of rhodamine. | |
| Membrane permeabilizing Antibiotic. Increases [32P] incorporation into phosphatidylinositol -4-phosphate. Seeking published researchers utilizing our Alamethicin product? Hit the hot link for the full paper. 1. Tailored Current - Voltage Relationships... | |
| Membrane permeable inositol phosphate derivative. Inquire for lead time from stock. | |
| Membrane-permeant enantiomer of myo-Inositol-1,3,4-T risphosphate derivative. Serves as control. Inquire for lead time from stock. | |
| Most popular form of Hygromycin B, the aminoglycosidic antibiotic used for the selection and maintenance of pro- and eukaryotic cells transfected with the E. coli hygromycin resistance gene. Seeking published... | |
| Native calpain-1 from porcine erythrocytes. The two major isoforms, calpain I (μ-form) and calpain II (m-form), differ in their calcium requirement for activation. Calpain I requires only micromolar amounts of... | |
| Natural occurring isomer of myo-inositol (product # I-1058). | |
| Naturally occurring antagonist of dihydrostreptomycin. Potent inhibitor of the respiratory chain binding to the mitochondrial cytochrome b protein. | |
| Naturally ocurring ion channel-forming pentadecapeptide antibiotic. Makes membranes permeable to protons and alkali metal ions, causes red blood cell lysis (at concentration 0.5-1.0ug/ml). Also causes non-voltage dependant K*/H* exchange in... | |
| Naturally-occurring phenolic compound with antioxidant properties. Inhibits the formation of tumors in mouse models or carcinogenesis caused by irritants such as PMA. | |
| Negative control for L-NMMA. Does not have any significant effect on Nitric Oxide Synthase. | |
| Neutral with very high selectivity for Ca2 ions. Determines Ca2 activity in membrane electrodes, also for transport studies in biological membranes. Custom manufactured bulk quantities 1-3g lead 2 weeks ,... | |
| Nicotinic Receptor Agonist. ** Available for domestic US sales. Product may incur dangerous good shipping charges ** | |
| Nitric Oxide inhibitor. Binds strongly to flavoproteins. NOTE: size change to 10mg for 2012. | |
| NMDA receptor antagonist. | |
| Non-cytotoxic inhibitor of caspase-1. | |
| Non-ionic detergent, similar to Octyl-β-D-glucopyran oside, Product # O-1036, with increased alkyl chain length.Useful in membrane-protein solubilization studies. Aggregation number: 98; micellar weight: 50,000; CMC: 100-600 uM; Absorbance (105, H2O,... | |
| Nonfluorescent calcium ionophore used as a calibration standard for determining cytoplasmic calcium ions by fluorescent probes. Inquire for bulk pricing. Also see A23187 free acid or A23187 Ca-Mg. | |
| Nonsteroidal anti-androgen. Induces cell death by a pathway that is independent of changes in mitochondrial membrane potential and Bcl-2 action. | |
| Orally active PI-3 kinase inhibitor; Dual PI3K/mTOR inhibition; BEZ235 showed high target specificity and demonstrated anti-proliferative activity against tumor cell lines in animal models of cancer. | |
| Over-activity of the epidermal growth factor receptor-associated tyrosine kinase (EGFR-TK) has been associated with a number of cancers and thus TK inhibitors could be potential therapeutic agents to prevent malignant... | |
| Pale yellow solid. Cell permeable acetoxymethyl ester (AM) derivative of FIP18 with spectral properties similar to the parent compound. A ratiometric dye with the same fluorescent properties and similar applications... | |
| Paullones represent a novel class of small molecule cyclin-dependent kinase (CDK) inhibitors. Alsterpaullone is a potent inhibitor of CDK1/cyclin B (IC50=0.035μM). High in vitro anti-tumor potency. Attached is a published... | |
| Paullones represent a novel class of small molecule cyclin-dependent kinase (CDK) inhibitors. Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC50=400 nM) also inhibits CDK2/cyclin A (IC50=680 nM). Weaker effect... | |
| Physiologically active metabolite of the immunosuppressive drug leflunomide (Cat. No.1972-10, 50). Inhibits the activity of dihydrorotate dehydrogenase and of protein tyrosine kinases. Blocks TNF-mediated NF-κB activation in a dose- and... | |
| Phytoestrogen. Selective, non-steroidal estrogen receptor α (ERα) ligand. Potent in vitro and in vivo angiogenesis inhibitor. Chemopreventive agent against cancer induced by heterocyclic amines. | |
| Possible potent and selective inhibitor of Protein Kinase C (IC50=0.66 μM). | |
| Potent and selective inhibitor of human telomerase (IC50 =4.5 μM), an effect which is unrelated to telomerase inhibition. | |
| Potent and selective inhibitor of protein kinase C (PKC). Inhibits PKC by interacting with the regulatory DAG binding site and phorbol ester binding site. Inhibition is light dependent. It also... | |
| Potent and selective irreversible inhibitor of neutral sphingomyelinase (N-SMase). ((+)-enantiomer) | |
| Potent anti-cancer agent whose potential target site may be mitochondrial cytochrome c oxidase. Inhibits RNA and DNA synthesis. Also inhibits eukaryotic topoisomerase I & II. Induces DNA single strand breaks... | |
| Potent anti-inflammatory and anti-neoplastic agent. Induces a CD95 death receptor-independent apoptosis even when the mitochondria protecting proteins Bcl-xL or Bcl-2 are overexpressed. Also an inhibitor of NF-κB | |
| Potent immunosuppressor. Inhibitor of the mitochondrial permeability transition pore (MPTP), preventing necrosis in several models. Isolated from Fusarium solani. | |
| Potent Immunosuppressor. | |
| Potent inhibitor of a-mannosidase I. Blocks the biosynthesis of complex-type oligosaccharides. Does not inhibit the biosynthesis of lipid-linked oligosaccharides. | |
| Potent inhibitor of histone deacetylase (HDAC) (IC50=700pM). | |
| Potent inhibitor of lipid peroxidation induced by free radicals, in rat brain homogenates and mouse plasma. | |
| Potent inhibitor of mitogen-activated protein kinase kinase-1, Inhibitor of G2 DNA damage checkpoint and cyclin-dependent kinases CDK1/cyclin B and CDK2/cyclin E glycogen synthase kinase-b. | |
| Potent inhibitor of PARP-1 and PARP-2 (potency ≤5 nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radio-potentiation. | |
| Potent inhibitor of PKA (Ki=3.0 μm), PKC (Ki=6 μm), PKG (Ki=5.8 nM), and myosin light chain kinase (Ki=97 μm). Selectivity for PKC can achieved when used in conjunction with HA-1004. | |
| Potent kainate/quisqualate receptor antagonist. | |
| Potent serine protease inhibitor. Inhibits both coagulation and complement proteinases, as well as, Granzyme A. Aids in proteomic preservation & stabilization. | |
| Potent, broad spectrum matrix metalloprotease (MMP) inhibitor (IC50 values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and... | |
| Potent, cell permeable and selective inhibitor of CDK1 (ICâ‚…â‚€=340nM) the cell cycle -regulating kinase Cdc28p (ICâ‚…â‚€=7μM) and the related Pho85p kinase (ICâ‚…â‚€=2μM). | |
| Potent, cell permeable non-tubulin-interact ing mitosis inhibitor. Blocks mitosis (IC50=200 nM) by binding to the mitotic kinesin Eg5. | |
| Potent, non-competitive mGluR1 antagonist (Ki=-0.34 nM). Inhibits glutamate-induced Ca2+ response at the human mGluR1 (IC50=0.55 nM). Selective over mGluR5 (>400-fold). | |
| Potent, selective inhibitor of Protein Kinase C isozymes, PKC β I(IC50=4.7 nM) and PKC β II (IC50=5.9 nM). Inquire for current availability & pricing from ready stock. Product is for... | |
| Potential anti-inflammatory agent. Inhibitor of cytokine induced IκBα phosphorylation, leading to decreased expression of NF-κB and adhesion molecules. | |
| Present as an active principle in the plant Magnolia grandiflora. Displays anxiolytic, antithrombotic, anti-tumor properties, etc. modulates the NF-κB activation pathway, an upstream effector VEGF, COX-2, and MCL1, all significant... | |
| Produced in E Coli, untagged mouse CDNF (aa 27-187). Conserved Dopamine Neurotropic Factor, CDNF, is a new protein with beneficial effects in dopaminergic neurons in a murine model of Parkinson's... | |
| Produced upon hormonal stimulation of cells. | |
| Product name change for 2012. Please inquire with customer service for price & product detail information. | |
| Ready-to-use colorimetric substrate for caspase-1/ICE and related caspases that recognize the amino acid sequence YVAD. Caspase-1 and related caspase activity can be quantified by spectrophotometric detection of free pNA (l=... | |
| Ready-to-use colorimetric substrate for caspase-2/Ich-1 and related caspases that recognize the amino acid sequence VDVAD. Caspase-2 and related caspase activity can be quantified by detection of free pNA after cleavage... | |
| Ready-to-use colorimetric substrate for caspase-4 and related caspases that recognize the amino acid sequence LEVD. Caspase-4 and related caspase activity can be quantified by spectrophotometric detection of free pNA (l=... | |
| Ready-to-use colorimetric substrate for caspase-5 and related caspases that recognize the amino acid sequence WEHD. Caspase-5 and related caspase activity can be quantified by spectrophotometric detection of free pNA (l... | |
| Ready-to-use colorimetric substrate for caspase-6/Mch2 and related caspases that recognize the amino acid sequence VEID. Caspase-6 and related caspase activity can be quantified by spectrophotometric detection of free pNA (l=... | |
| Ready-to-use colorimetric substrate for caspase-9/Mch6 and related caspases that recognize the amino acid sequence LEHD. Caspase-9 and related caspase activity can be quantified by spectrophotometric detection of free pNA (l=... | |
| Ready-to-use colorimetric substrate for caspases that recognize the amino acid sequence AEVD. Caspase activity can be quantified by spectrophotometric detection of free pNA (l = 400 nm) after cleaved from... | |
| Ready-to-use colorimetric substrate for CPP32/caspase-3 and related caspases that recognize the amino acid sequence DEVD. The sequence DEVD is based on caspase-3 cleavage site in poly (ADP-ribose) polymerase (PARP). CPP32... | |
| Ready-to-use colorimetric substrate for FLICE/caspase-8 and related caspases that recognize the amino acid sequence IETD. The sequence IETD is based on caspase-8 cleavage site in CPP32/Caspase-3 proenzyme. FLICE and related... | |
| Ready-to-use fluorometric substrate for AEVD-dependent caspases. Activity of AEVD-dependent caspase activity can be quantified by fluorescent detection of free AFC after cleavage from the peptide substrate AEVD-AFC at Ex. =... | |
| Ready-to-use fluorometric substrate for caspase-1,-4,-5 and related caspases that recognize the amino acid sequence WEHD. Caspase-5 and related caspase activity can be quantified by fluorescent detection of free AFC after... | |
| Ready-to-use fluorometric substrate for caspase-1/ICE and related caspases that recognize the amino acid sequence YVAD. Caspase-1 and related caspase activity can be quantified by fluorescent detection of free AFC after... | |
| Ready-to-use fluorometric substrate for caspase-13 and related caspases that recognize the amino acid sequence LEED. Caspase-13 and related caspase activity can be quantified by fluorescent detection of free AFC after... | |
| Ready-to-use fluorometric substrate for caspase-3/CPP32 (Km = 9.7 μM) and related caspases that recognize the amino acid sequence DEVD. The sequence DEVD is based on caspase-3 cleavage site in poly... | |
| Ready-to-use fluorometric substrate for caspase-4 and related caspases that recognize the amino acid sequence LEVD. Caspase-4 and related caspase activity can be quantified by fluorescent detection of free AFC after... | |
| Ready-to-use fluorometric substrate for caspase-6 and related caspases that recognize the amino acid sequence VEID. Caspase-6 and related caspase activity can be quantified by fluorescent detection of free AFC after... | |
| Ready-to-use fluorometric substrate for caspase-9/Mch-6 and related caspases that recognize the amino acid sequence LEHD. Caspase activity can be quantified by fluorescent detection of free AFC after cleavage from the... | |
| Ready-to-use fluorometric substrate for caspases that recognize the amino acid sequence ATAD. Caspase activity can be quantified by fluorescent detection of free AFC after cleaved from the peptide substrate ATAD-AFC... | |
| Ready-to-use fluorometric substrate for caspases that recognize the amino acid sequence VDVAD. Caspase activity can be quantified by fluorescent detection of free AFC after cleaved from the peptide substrate VDVAD-AFC... | |
| Ready-to-use fluorometric substrate for FLICE/caspase-8 and related caspases that recognize the amino acid sequence IETD. The sequence IETD is based on caspase-8 cleavage site in CPP32/caspase-3 proenzyme. FLICE and related... | |
| Recombinant human Annexin V (FITC), expressed in bacteria, purified. *Shows bright green fluorescence (Ex(max): 488nm; Em(max): 530nm) Annexin V Associates with the IFN- Receptor and Regulates IFN-Signaling Carlos Leon, Devki... | |
| Reported agonist at the TRPV1 receptor. A powerful excitant of peripheral sensory nerve endings, particularly unmyelinated afferent neurons (C-fibers). Reversible platelet aggregation inhibitor. Isolated from Capsicum fruit. | |
| Reversible and cell permeable inhibitor of caspase-1. Peptide Content: 78-98% | |
| Reversible inhibitor for caspase-4. Also inhibits caspase-5. | |
| Reversible inhibitor of caspase-2. Peptide content: 70-90%. | |
| Reversible inhibitor of caspase-3 and caspase-7. Peptide content:70-90% | |
| Reversible inhibitor of caspase-8 and granzyme B. Inhibits also caspase-10. Peptide content: 70-90% | |
| Reversible Inhibitor of granzyme B and caspase-8. Inhibits also caspase-6 and -10. This peptide sequence corresponds to one of the cleavage sites of the inactive 32 kDa caspase-3 precursor (aa25-28). | |
| Reversibly inhibits nuclear topoisomerase I by binding to and stabilizing the topoisomerase-DNA covalent complex. Inhibits Tat-mediated transcription of HIV-1. Induces apoptosis in Jurkat, osteosarcoma and hepatoma cells. | |
| rhsMegaAPRIL induces Swiss NIH-3T3 cells to proliferate in low serum conditions. Concentration:0.1mg/ ml after reconstitution. Application: Can be used to sustain proliferation of serum-starved NIH-3T3 cells. *M.W.: For the chimeric... | |
| Selective 5-HT2 & 5-HT1C serotonin receptor antagonist. | |
| Selective agonist for group II mGluRs. Inquire for pricing & lead time of other ACPD products available from A.G. Scientific. | |
| Selective and strong inhibitor of cyclin-dependent kinases. Inhibits the proliferation of a large range of cells, mainly through arresting the cells in the G2/M phase of the cell cycle. | |
| Selective antagonist of GABAB receptors, which demonstrates a higher selectivity than phaclofen. | |
| Selective inhibitor of HER2 compared to HER1 (IC50=0.35μM vs. 19μM for EGFR and 40μM for PDGFR). | |
| Selective inhibitor of platelet-derived growth factor (PDGF) receptor protein. | |
| Selective inhibitor of rat brain Ca2+/calmodulin-depe ndent protein kinase II. Induces G1 cell cycle arrest and apoptosis. | |
| Selective Inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor. | |
| Selective telomerase inhibigtor (IC50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere... | |
| Selectively inhibits CDK2 activation leading to a potent cell cycle arrest at late G1 and S phase. Cell permeable inhibitor of JAK-2 tyrosine kinase. Does not significantly inhibit other kinases,... | |
| Sensitivity: 0.4U/ml. Quantity: 96 wells. Specificity: Human leptin receptor. Application: Quantitative measurement of human leptin receptor in serum, plasma and tissue culture medium. | |
| Sensitivity: 0.5 ng/ml. Quantity: 96 wells. Kit/Set Contains: Includes instructions and reagents (anti-leptin, horseradish peroxidase conjugate, human leptin standards, buffers, substrate solution, quality control). | |
| Shows anti-tumor, anti-viral and anti-oxidant actions. Small molecule inhibitor of Bcl-2/Bcl-XL. Induces apoptosis. Synergizes with radiation and chemotherapy in vitro. Also male antifertility agent. | |
| Source: beauveria bassiana. Depsipeptide from the enniatin family, which shows activity against gram-positive bacteria and mycobacteria. Also active against insects and brine shrimp. Beauvericin allows transport of alkaline earth metal... | |
| Source: Goat. Immunogen: Synthetic peptide (CLATEDAD-SENSSFYYYD YLDEVAFML) corresponding to N-terminal (aa 10-35) human bets-chemokine receptor D6. Specificity: Recognizes human β-chemokine receptor D6. Application: Immunocytochemistry (dilution 1:400), Western Blot (dilution 1:1000). | |
| Source: Produced in HEK 293 cells. The non-homologous (aa16-45) and collagen domain of human ACRP30 (aa 45-108) are fused at the N-terminus to a FLAG-epitope tag. Reconstitution: Reconstitute with 100μl... | |
| Source: Produced in HEK 293. Mouse ACRP30 (aa 18-247) fused at the N-terminus to a linker peptide (8 aa) and a FLAG tag. Reconstitution: Reconstitute with 50μl sterile water. Application:... | |
| Source: Rabbit. Immunogen: Free HNE coupled to KLH. Specificity: To visualize HNE-adducts. Application: WB, ELISA. ELISA (dilution 1:1000 to 1:10000), Immunohistochemistry (1:250-1000), Western Blot (dilution 1:250 to 1:1000). | |
| Source: Rabbit. Immunogen: Recombinant human lipoma preferred partner (LPP) (aa 1-109). Specificity: Raised against a recombinant fusion protein comprising residues 1-109 of human LPP. Recognizes human, porcine and rat LPP. | |
| Source: Rabbit. Immunogen: Synthetic peptide corresponding to the N-terminal aa residues 1-11 (M1VTSLNEDNES11C) of human and mouse KIF2 with a C-terminal cysteine added for conjugation to KLH. Concentration: 1mg/ml. Specificity:... | |
| Source: Rabbit. Specificity: Raised against a 81 kDa polypeptide corresponding to human Dia1 aa 727-765 (end of FH1 domain) and 1121-1145 (C-terminal coil), respectfully. Recognizes human and porcine Dia1. Application:... | |
| Specific and irreversible inhibitor of HMG-CoA synthase in vitro and in vivo. Inhibits mevalonate biosynthesis. Shows anti-microbial and anti-fungal activity. | |
| Sterile-filtered, Broad spectrum, cell culture antibiotic that is non toxic to viruses and mammalian cells at antibacterial levels. It is useful for long-term virus and tissue culture studies. ******************** **************... | |
| Strong anti-tumor agent and anti-cancer agent. Selectively inhibits phosphatidylinositol phospholipase C and induces expression of c-fos, c-jun, and transcription factor AP-1. | |
| Strong antibiotic activity against gm-positive bacteria and cytotoxicity. Shows inhibitory effects on cellular adhesion and anaphylatoxin receptor binding. | |
| Substrate for caspase-6. Chromogenic; λ max. 405nm. | |
| Substrate for caspase-9, Chromogenic; λ max: 400nm. | |
| Substrate for granzyme B with increased cell permeability. Also a substrate for caspase-10. Peptide Content: 70-90%. | |
| Substrate of caspase-3 with increased cell permeability. Also reported subtrate for caspase 1, 4 and 7. λ max of pNA is 400nm. | |
| Suggested to play a second-messenger role different from that of Ins(1,4,5)P3. | |
| Synthetic derivative of coelenterazine with luminescence intensity almost 50 times higher than native coelenterazine. Response time to calcium is much slower than native form. | |
| Synthetic derivative of coelenterazine. Luminescence intensity of its aequorin complex is 135 times higher than native coelenterazine. | |
| Synthetic derivative of coelenterazine; exhibits luminescence intensity of its aequorin complex ~ 3% great than native coelenterazine. Has slowest response time to calcium of the coelenterazine analogs | |
| Synthetic. Highly specific, cell permeable, and irreversible 20S proteasome inhibitor. It is believed lactacystin acts as a precursor for clasto-lactacystin b-lactone. New size for 2010. | |
| Synthetic. Sensitive and specific intracellular luminophore. Exhibits almost 20 times higher luminescence intensity than native coelenterazine; emission maximum is about 8 nm longer. Useful for measuring changes in superoxide and... | |
| Synthetically produced. Cell permeable, irreversible proteasome inhibitor. Specifically inhibits the 20S and 26S proteasome. Blocks proteasome activity by targeting the catalytic β-subunit. Has no effect on serine or cysteine proteases. | |
| The alkaloid berberine exhibits relatively weak antibiotic properties (1), apparently because of its efflux by multidrug resistance pumps (s). Recently it was described that the anti-microbial action of berberine is... | |
| The expressed caspase-9 spontaneously undergoes autoprocessing to yield the subunits characteristic of the native enzyme. Active enzyme purified from E. coli. This product is useful in screening caspase inhibitors for... | |
| The free form of AFC can be used as a fluorescent marker and reference standard for fluorogenic enzyme assays using AFC-based substrates. | |
| The reagent can be used as a negative control for FMK-labeled caspase inhibitors. | |
| The set contains 10 μg of rhsFas ligand and 4x50 μg of an enhancer which increases the biological activity by approx. 50-fold to a concentration range of 1-5ng/ml. | |
| The tetramic acid, Equisetin, is produced by a number of species of Fusarium. Interest in equisetin emerged with reports of its inhibitory activity against human immunodeficiency virus type 1 (HIV-1)... | |
| The tetronic acid, chlorothricin is an unusual macrocyclic antibiotic from Streptomyces sp. Related to kijanimicin, sccharocarcins, tetrocarcin and versipelostatin. It shows inhibitory activity against cholesterol biosynthesis from mevalonate and inhibits... | |
| This Chymostatin consists of A,B,C forms, where A is a major form. Acts as a protease inhibitor, specifically for CTR (chymotrypsin) (ID50 = 150 ηg/ml), Papain (ID50 = 7.5 μg/ml),... | |
| This coelenterazine derivative is membrane-permeant, nontoxic, and highly reactive toward ROS. Methyl coelenterazine is a reported superior antioxidant for cells against reactive oxygen species (ROS) such as singlet oxygen and... | |
| This sterile solution is composed of penicillin (10000-12000 units/ml), streptomycin (10000-12000 ug/ml), and amphotericin B (25-30 ug/ml). The Antibiotic-antimycot ic solution works both as an antibacterial and an antifungal. It... | |
| Topoisomerase II inhibitor. Anti-tumor reagent. Widely used apoptosis inducer by FasL. Semisynthetically derived from podophyllotoxin. | |
| Tyrosine kinase inhibitor reported to block TNFα induced cytotoxicity. Also blocks glucocorticoid-induc ed COX-2 activity in human amnion cells (IC50=21μM). | |
| Tyrphrostin is available by custom manufacture & synthesis. Lead is 4-6 weeks call for minimum volume requirments & a price quotation. | |
| Unique aminogylcoside antibiotic with less potential to create cross-resistant human pathogens compared to other aminoglycoside antibiotics [1]. | |
| Used for the selection and maintenance of pro- and eukaryotic cells transfected with the E. coli hygromycin resistance gene. Seeking published scientists that has used our HYGROMYCIN B? Click on... | |
| Used to detect apoptotic cells. It has a strong affinity for phosphatidylserine which is translocated to the outer layer of the cell membrane during the early phases of apoptosis. Annexin... | |
| VEID is the specific recognition sequence for caspase-6/Mch2. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant... | |
| Wheat germ (Triticum aestivum) calmodulin (CaM) sequence is unique in that it contains cysteine at residue position 26 (Cys26). In contrast to mammalian CaMs, which lack cysteine, this preparation is... |
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