E-64 is an Irreversible, potent and highly selective inhibitor of cysteine proteases. Does not affect cysteine residues in other enzymes. Acts by forming a thioether bond with thiol of the active cysteine.
E-64 will not inhibit serine proteases (except trypsin) inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.
E-64 is a very useful cysteine protease inhibitor for use in in vivo studies because it has a specific inhibition; it is permeable in cells and tissues & has low toxicity. E-64 inhibits calpain, papain, and cathespin B, cathepsin L, bromelain, staphopain, collegenase and ficin.
The compound has been reported to inhibit intracellular Bax protease activity, and reduce oxidative stress, which includes a decrease in MDA levels, ICAM-1 expression and MOP activity. E-64 has also been used to study excystation (microbial cyst wall breaks down ) in Giardia lamblia. Effective concentration 1-10 uM.
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37 FAQs on E-64, Cysteine Protease Inhibitor, Need to know. CLICK HERE.
| A.G. Scientific, Inc. | |
|---|---|
| Product Category | Biological Materials |
| Product Number | E-2030 |
| Product Name | E-64 |
