Borrelidin, an 18-membered macrolide-polyketide
, is a compound with anti-viral, anti-bacterial, anti-malarial, and anti-angiogenic properties. It is a known inhibitor of bacterial and eukaryal threonyl-tRNA synthetases. Borrelidin induces apoptosis in endothelial cells via the caspase 3 and caspase 8 pathway. In addition, borrelidin strongly inhibits capillary tube formation and also disrupts formed capillary tubes by inducing apoptosis of the tube-forming cells in a rat aorta matrix culture model. In S.cerevisiae, borrelidin inhibits the cyclin-dependent kinase Cdc28/Cln2 with an IC50 of 24 μM, causing the arrest of both haploid and diploid cells in G1 phase and inducing the transcription of amino acid biosynthetic enzymes through a GCN4-dependent pathway. Seeking published researchers utilizing our Borrelidin product? Hit the hot link for the full paper. 1. Role of antibiotic ligand in nascent peptide-dependent ribosome stalling, Nora Vázquez-Laslop, Dorota Klepacki, et al, Jun 2011; 108: 10496 - 10501.
Borrelidin, an 18-membered macrolide-polyketide, is a compound with anti-viral, anti-bacterial, anti-malarial, and anti-angiogenic properties. It is a known inhibitor of bacterial and eukaryal threonyl-tRNA synthetases.
Borrelidin induces apoptosis in endothelial cells via the caspase 3 and caspase 8 pathway. In addition, borrelidin strongly inhibits capillary tube formation and also disrupts formed capillary tubes by inducing apoptosis of the tube-forming cells in a rat aorta matrix culture model. In S.cerevisiae, borrelidin inhibits the cyclin-dependent kinase Cdc28/Cln2 with an IC50 of 24 μM, causing the arrest of both haploid and diploid cells in G1 phase and inducing the transcription of amino acid biosynthetic enzymes through a GCN4-dependent pathway.
Seeking published researchers utilizing our Borrelidin product? Hit the hot link for the full paper.
1. Role of antibiotic ligand in nascent peptide-dependent ribosome stalling, Nora Vázquez-Laslop, Dorota Klepacki, et al, Jun 2011; 108: 10496 - 10501.
