Fitzgerald Industries International, Inc. Datasheets for Biological Materials

Biological materials are biocompatible materials, natural or man-made, that comprise a whole or a part of a living structure or biomedical device that performs, augments, or replaces a natural function
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Product Name Notes
Mouse anti Human IgG Fc fragment antibody Background: The IgG fc fragment does not bind antigen; however, it does contain the classic antigenic determinants and biological activity with respect to...
Mouse monoclonal 160 kDa Neurofilament Protein antibody Background: Neurofilaments are the 10 nanometer (10nm) intermediate filaments found specifically in neurons. The subunits of neurofilaments are related structurally to the 10nm...
Mouse monoclonal 200 kDa Neurofilament Protein antibody Background: Neurofilaments are the 10 nanometer (10nm) intermediate filaments found specifically in neurons. The subunits of neurofilaments are related structurally to the 10nm...
Mouse monoclonal 4EBP1 antibody Background: 4EBP1 which is located on chromosome 8p12, with 118-amino acid protein (about 13kDa). Binding of eIF4EBP1 to eIF4E is reversible and is dependent on the...
Mouse monoclonal 70/200 kDa Neurofilament protein antibody Background: Neurofilaments are the 10 nanometer (10nm) intermediate filaments found specifically in neurons. The subunits of neurofilaments are related structurally to the 10nm...
Mouse monoclonal A1BG antibody Background: A1BG is a plasma glycoprotein of unknown function. It shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. A1BG was...
Mouse monoclonal AAT antibody Background: Alpha 1-Antitrypsin is a protease inhibitor belonging to the serpin superfamily. It is generally known as serum trypsin inhibitor. Alpha 1-antitrypsin is also referred to...
Mouse monoclonal ABL1 antibody Background: The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and...
Mouse monoclonal ABL2 antibody Background: ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains...
Mouse monoclonal ADARB1 antibody Background: This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that...
Mouse monoclonal ADK antibody Background: Adenosine kinase (ADK) is the key regulator of adenosine metabolism. Because of the manifold receptor-dependent actions of adenosine, tight regulation of adenosine levels is crucial.
Mouse monoclonal AEBP2 antibody Background: This gene functions as a DNA-binding transcriptional repressor. It may also interact with and stimulate the activity of the PRC2 complex,which methylates 'Lys-9' and 'Lys-27'...
Mouse monoclonal AFP antibody Background: AFP is a protein that in humans is encoded by the AFP gene. Alpha-fetoprotein is a major plasma protein produced by the yolk sac and...
Mouse monoclonal AGT antibody Background: The AGT gene provides instructions for making a liver enzyme called alanine-glyoxylate aminotransferase. Inside liver cells, this enzyme is found in peroxisomes, structures that contain...
Mouse monoclonal AHR antibody Background: This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate...
Mouse monoclonal AKR1C1 antibody Background: The human aldo-keto reductases 1C1 and 1C3 (AKR1C1 and AKR1C3) have major roles in pre receptor regulation of progesterone action. They can both convert progesterone...
Mouse monoclonal AKT3 antibody Background: AKT3 is a member of the AKT serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin...
Mouse monoclonal Albumin antibody Background: Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty...
Mouse monoclonal Amyloid A antibody Background: Amyloids are insoluble fibrous protein aggregates sharing specific structural traits. Abnormal accumulation of amyloid in organs may lead to amyloidosis, and may play a...
Mouse monoclonal Antibody Pair to ApoA-V antibody Background: Apolipoprotein A-V is a protein that in humans is encoded by the APOA5 gene. The protein encoded by this gene is an...
Mouse monoclonal ApoA antibody Background: Apolipoprotein A is a protein that in humans is encoded by the APOA1 gene. It has a specific role in lipid metabolism. Apolipoprotein A is...
Mouse monoclonal ApoA-I antibody Background: Apolipoprotein A-I is a protein that in humans is encoded by the APOA1 gene. It has a specific role in lipid metabolism. Apolipoprotein A-I is...
Mouse monoclonal ApoA-IV antibody Background: APOA4 is a 396-residue preprotein, which undergoes proteolytic processing to yield apo A-IV, a 376-reside mature O-linked glycoprotein. In most mammals, including humans, apo A-IV...
Mouse monoclonal ApoA-V (ab) antibody Background: Apolipoprotein A-V is a protein that in humans is encoded by the APOA5 gene. The protein encoded by this gene is an apolipoprotein and...
Mouse monoclonal ApoA-V (bd) antibody Background: Apolipoprotein A-V is a protein that in humans is encoded by the APOA5 gene. The protein encoded by this gene is an apolipoprotein and...
Mouse monoclonal ApoM antibody Background: Apolipoproteins are protein components of plasma lipoproteins. APOM is a member of the lipocalin family of proteins. APOM is exclusively expressed in kidney tubular epithelial...
Mouse monoclonal APP antibody Background: Amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not...
Mouse monoclonal AR antibody Background: AR functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and...
Mouse monoclonal AR antibody Background: The androgen receptor (AR), is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in...
Mouse monoclonal ARF1 antibody Background: ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family member is essential and ubiquitous in eukaryotes, being involved in...
Mouse monoclonal ARIH2 antibody Background: This gene may play a role in myelopoiesis.
Mouse monoclonal ARNTL antibody Background: ARNTL is a gene which is associated with susceptibility to hypertension and type 2 diabetes. The protein encoded by this gene is a basic-helix-loop-hel ix...
Mouse monoclonal ATF6 antibody Background: ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules. Accumulation of misfolded proteins in the Endoplasmic Reticulum...
Mouse monoclonal ATF7 antibody Background: This gene plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3 '), a sequence present in many viral and...
Mouse monoclonal AURKB antibody Background: The aurora family (A, B and C) are serine threonine kinases and key regulators of chromosome segregation during mitosis. Aurora kinase B is a chromosomal...
Mouse monoclonal AXL antibody Background: AXL is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure...
Mouse monoclonal B Cell Antigen antibody Background: B cells are lymphocytes that play a large role in the humoral immune response (as opposed to the cell-mediated immune response, which is...
Mouse monoclonal B Cell Antigen CD19 antibody Background: CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage...
Mouse monoclonal B Cell Antigen CD21 antibody Background: CD21 is a protein involved in the complement system. It binds to iC3b (inactive derivative of C3b), C3dg, or C3d. B cells...
Mouse monoclonal B Cell Antigen MB2 antibody Background: B cells are lymphocytes that play a large role in the humoral immune response (as opposed to the cell-mediated immune response, which...
Mouse monoclonal B Cell Antigen MB3 antibody Background: B cells are lymphocytes that play a large role in the humoral immune response (as opposed to the cell-mediated immune response, which...
Mouse monoclonal BCCIP antibody Background: This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple...
Mouse monoclonal Bcl10 antibody Background: Bcl10 is a novel gene with an amino-terminal caspase-recruiting domain (CARD), which is thought to be involved in mucosa-associated lymphoid tissue lymphomas and in the...
Mouse monoclonal BLK antibody Background: BLK may function in a signal transduction pathway that is restricted to B-lymphoid cells.
Mouse monoclonal BMX antibody Background: BMX is a cytoplasmic tyrosine kinase identified by reverse transcription of mRNA isolated from human bone marrow and mapped to the chromosomal band Xp22. 2.
Mouse monoclonal BNC2 antibody Background: This gene is most likely a transcription factor specific for skin keratinocytes. It may also play a role in the differentiation of spermatozoa and oocytes.
Mouse monoclonal BNP antibody Background: Brain natriuretic peptide (BNP) circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. BNP is secreted predominantly by the left...
Mouse monoclonal BRAF antibody Background: BRAF is one of the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway. B-Raf contains three consensus Akt phosphorylation sites. B-Raf...
Mouse monoclonal BRDU antibody Background: Bromodeoxyuridine (5-bromo-2'-deoxyuri dine, BrdU) is a synthetic nucleoside that is an analogue of thymidine. BrdU is commonly used in the detection of proliferating cells in...
Mouse monoclonal BRRN1 antibody Background: This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion...
Mouse monoclonal BSA antibody Background: Albumin refers generally to any protein that is water soluble, which is moderately soluble in concentrated salt solutions, and experiences heat denaturation. They are commonly...
Mouse monoclonal BUB1B antibody Background: This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition...
Mouse monoclonal c-Kit antibody Background: Proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117 is a protein that in humans is encoded by the KIT gene. Multiple transcript variants encoding different...
Mouse monoclonal C1orf33 antibody Background: This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is...
Mouse monoclonal CA1 antibody Background: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological...
Mouse monoclonal CALCOCO2 antibody Background: The protein encoded by this gene is a subunit of nuclear domain 10 (ND10) bodies. ND10 bodies are nuclear domains appearing immunohistochemicall y as ten...
Mouse monoclonal Calcyclin antibody Background: Calcyclin is a member of the S100 family of proteins. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells,...
Mouse monoclonal cAMP antibody Background: Cyclic adenosine monophosphate is a second messenger important in many biological processes. cAMP is derived from adenosine triphosphate (ATP) and used for intracellular signal transduction...
Mouse monoclonal CASQ2 antibody Background: CASQ2 (Calsequestrin 2) protein responsible for holding Calcium together with other two proteins junction and triadin at the sarcoplasmic reticulum renders the hear vulnerable to...
Mouse Monoclonal CBR1 antibody Background: Carbonyl reductase 1 (CBR1) is an NADPH-dependent, monomeric, and cytosolic enzyme belonging to a family of short-chain dehydrogenases/reduc tases. This protein consists of 277 amino...
Mouse monoclonal CCNB1 antibody Background: CCNB1 is a regulatory protein involved in mitosis. CCNB1 complexes with p34(Cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a...
Mouse monoclonal CCNB1IP1 antibody Background: E3 ubiquitin-protein ligase CCNB1IP1 is an enzyme that in humans is encoded by the CCNB1IP1 gene. HEI10 is a member of the E3 ubiquitin ligase...
Mouse monoclonal CCND1 antibody Background: During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by acting as...
Mouse monoclonal CCND1 antibody Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout...
Mouse monoclonal CCNH antibody Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through...
Mouse monoclonal CD10 antibody Background: CD10 is a cell surface enzyme with neutral metalloendopeptidase activity which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of...
Mouse monoclonal CD117 antibody Background: The c-Kit proto-oncogene encodes a 145 kD transmembrane receptor for stem cell factor with tyrosine kinase activity. C-Kit is closely related to the platelet-derived growth...
Mouse monoclonal CD166 antibody Background: CD166 is a member of the Ig superfamily and is expressed on activated T-cells, B cells and other cells including thymic epithelial cells, fibroblasts, keratinocytes...
Mouse monoclonal CD18 antibody Background: Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They...
Mouse monoclonal CD19 antibody Background: CD19 is a protein that in humans is encoded by the CD19 gene. CD19 is expressed on follicular dendritic cells and B cells. In fact,...
Mouse monoclonal CD20 antibody Background: CD20 is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon...
Mouse monoclonal CD247 antibody Background: CD247, together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an...
Mouse monoclonal CD3 antibody Background: In immunology, the CD3 T-Cell Co-Receptor is a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3 Delta...
Mouse monoclonal CD33 antibody Background: CD33 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid...
Mouse monoclonal CD37 antibody Background: CD37 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized...
Mouse monoclonal CD38 antibody Background: CD38 is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. CD38 also...
Mouse monoclonal CD3E antibody Background: CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11. The protein encoded by this gene is...
Mouse monoclonal CD40 antibody Background: CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to...
Mouse monoclonal CD44 antibody Background: CD44 (HCAM) is a transmembrane protein expressed by lymphocytes, erythrocytes and several normal epithelial cells and is a member of the CAM family. It is...
Mouse monoclonal CD44 antibody Background: The CD44 antigen is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. In humans, the CD44 antigen is encoded by the CD44...
Mouse monoclonal CD50 antibody Background: The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain...
Mouse monoclonal CD57 antibody Background: CD57 antigen is a protein which is also called HNK1 (human natural killer-1) or LEU7. It is a neuronally expressed adhesion molecule with a carbohydrate...
Mouse monoclonal CD8 antibody Background: CD8 is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility...
Mouse monoclonal CD80 antibody Background: CD80 is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is...
Mouse monoclonal CD86 antibody Background: CD86 is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two...
Mouse monoclonal Cdc2 antibody Background: Cdc2 plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists...
Mouse monoclonal Cdc27 antibody Background: Cdc27 shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. It is a component of the Anaphase...
Mouse monoclonal CDH1 antibody Background: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting...
Mouse monoclonal CDH2 antibody Background: Cadherin 2 a classical cadherin from the cadherin superfamily. Cadherin 2 is a calcium dependent cell-cell adhesion glycoprotein comprising five extracellular cadherin repeats, a transmembrane...
Mouse monoclonal CDKN1B antibody Background: CDKN1B is a cell cycle regulatory mitotic inhibitor of cdk activity. CDKN1B is a candidate tumor suppressor gene, and has been proposed to function as...
Mouse monoclonal CDw75 antibody Background: CDw75 is a neuraminidase-sensit ive sialoprotein, present on cell membrane and cytoplasm of germinal center B-cells and derived lymphomas. LN1 reacts with RBC precursors of...
Mouse monoclonal CEBPG antibody Background: The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs...
Mouse monoclonal CER1 antibody Background: CER1 is a member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan...
Mouse monoclonal CgA antibody Background: Chromogranin A (a protein of 439-amino acids which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells...
Mouse monoclonal CGI-121 antibody Background: CGI-121 is a component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have...
Mouse monoclonal CHAF1A antibody Background: Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60, and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in...
Mouse monoclonal CHIT1 antibody Background: CHIT1 is a 50 kDa secreted glycoprotein that belongs to glycohydrolase family # 18. It is secreted by activated human macrophages and is markedly elevated...
Mouse monoclonal CHK1 antibody Background: CHK1 is a kinase that phosphorylates Cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216...
Mouse monoclonal CHK2 antibody Background: CHK2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA...
Mouse monoclonal CHRAC1 antibody Background: CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence independent manner. These histone-fold protein dimers combine within...
Mouse monoclonal CHUK antibody Background: CHUK is a member of the serine/threonine protein kinase family, CHUK is a component of a cytokine-activated protein complex that is an inhibitor of the...
Mouse monoclonal CIP29 antibody Background: This gene may have nucleic acid binding capability that may participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis.
Mouse monoclonal CIRH1A antibody Background: Cirhin is a protein that in humans is encoded by the CIRH1A gene. It has been associated with Indian childhood cirrhosis, a form of cirrhosis...
Mouse monoclonal CIRH1A antibody Background: This gene has been associated with Indian childhood cirrhosis, a form of cirrhosis of the liver occurring in American Indian children.
Mouse monoclonal CK1 antibody Background: CK1 is a member of the keratin family. It is specifically expressed in the spinous and granular layers of the epidermis with family member keratin...
Mouse monoclonal Clenbuterol antibody Background: Clenbuterol is a sympathomimetic amine used by sufferers of breathing disorders as a decongestant and bronchodilator. People with chronic breathing disorders such as asthma use...
Mouse monoclonal CLOCK antibody Background: CLOCK is a gene encoding a basic-helix-loop-hel ix-PAS transcription factor (CLOCK) that affects both the persistence and period of circadian rhythms. CLOCK functions as an...
Mouse monoclonal CNNM3 antibody Background: This gene probably encodes a metal transporter (By similarity).
Mouse monoclonal CNOT8 antibody Background: This gene encodes an ubiquitous transcription factor required for a diverse set of processes. The CCR4-NOT complex functions as general transcription regulation complex.
Mouse monoclonal COIL antibody Background: The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number...
Mouse monoclonal CPSF2 antibody Background: The 160 kDa subunit of human cleavage-polyadenyla tion specificity factor coordinates pre-mRNA 3'-end formation.
Mouse monoclonal CRSP9 antibody Background: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with...
Mouse monoclonal CRTC1 antibody Background: CRTC1 is a protein that in humans is encoded by the CRTC1 gene. It is expressed in a limited number of tissues that include fetal...
Mouse monoclonal CRTC2 antibody Background: CRTC2 is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP.
Mouse monoclonal CRY1 antibody Background: This gene is a blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining...
Mouse monoclonal CRYAB antibody Background: Alpha crystallins are composed of two gene products ; alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock...
Mouse monoclonal CSF1 antibody Background: CSF1 is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked...
Mouse monoclonal CSF2 antibody Background: CSF2 is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as...
Mouse Monoclonal CTBP1 antibody Background: The C-terminal-binding protein (CtBP) was originally identified as a cellular protein that interacts with a C-terminal motif of adenovirus E1A oncoproteins. CtBP is highly conserved...
Mouse monoclonal cTnI antibody Background: cTnI along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of...
Mouse monoclonal CTNNB1 antibody Background: CTNNB1 is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers...
Mouse monoclonal CTNNBL1 antibody Background: The protein encoded by this gene contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation...
Mouse monoclonal Cytokeratin Pan antibody Background: Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). The type...
Mouse monoclonal DAZAP1 antibody Background: In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have...
Mouse monoclonal DCTN4 antibody Background: This gene could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding...
Mouse monoclonal DDR1 antibody Background: DDR1 is a Receptor Tyrosine Kinase that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This...
Mouse monoclonal DDX17 antibody Background: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration...
Mouse monoclonal DFFA antibody Background: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of...
Mouse monoclonal DHX16 antibody Background: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration...
Mouse monoclonal DHX57 antibody Background: This gene probably encodes an ATP-binding RNA helicase.
Mouse monoclonal DKK1 antibody Background: Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene. This gene encodes a protein that is a member of...
Mouse monoclonal DOCK7 antibody Background: Dock7 (Dedicator of cytokinesis 7), also known as Zir2, is a large (240 kDa) protein involved in intracellular signalling networks. It is a member of...
Mouse monoclonal DPF2 antibody Background: The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as...
Mouse monoclonal E Cadherin antibody Background: Cadherins are a class of type-1 transmembrane proteins. They play important roles in cell adhesion, ensuring that cells within tissues are bound together. They...
Mouse monoclonal E7 antibody Background: The E7 transforming protein of Human papillomavirus type 16.
Mouse monoclonal EBNA2 antibody Background: This gene functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as...
Mouse monoclonal EGF antibody Background: Epidermal growth factor or EGF is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding...
Mouse monoclonal EGR1 antibody Background: EGR1 belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target...
Mouse monoclonal EIF2AK3 antibody Background: EIF2AK3 phosphorylates the alpha subunit of eukaryotic translation-initiati on factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation...
Mouse monoclonal EIF2S1 antibody Background: Eukaryotic translation initiation factor 2, subunit 1 alpha (EIF2S1) is plays a central role in initiating translation, and provides for a rate-limiting step in protein...
Mouse monoclonal ELAC1 antibody Background: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
Mouse monoclonal ELK1 antibody Background: The transcription factor ELK1 is a family of member of ETS oncogene family and of the ternary complex factor (TCF) subfamily,which is located on chromosome...
Mouse monoclonal eNOS antibody Background: eNOS is an important enzyme in the cardiovascular system. It is a reactive free radical which acts as a biologic mediator in several processes, including...
Mouse monoclonal EP300 antibody Background: EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CBP (CREB-binding protein), and like CBP can stimulate transcription...
Mouse monoclonal EphA3 antibody Background: EphA3 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in...
Mouse monoclonal EPHA4 antibody Background: EPHA4 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in...
Mouse monoclonal EPHA5 antibody Background: EPHA5 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in...
Mouse monoclonal EphA6 antibody Background: The Eph subfamily represents the largest group of receptor protein tyrosine kinases identified to date. While the biological activities of these receptors have yet to...
Mouse monoclonal EphA8 antibody Background: EphA8 is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events,...
Mouse monoclonal EphB3 antibody Background: Ephrin receptors and their ligands, the Ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, Ephrins are...
Mouse monoclonal EPHB4 antibody Background: EPHB4 is a member of the Eph receptor family, which bind the ephrin ligand family. Based on their structures and sequence relationships, ephrins are divided...
Mouse monoclonal EPHB4 antibody Background: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are...
Mouse monoclonal EPHB6 antibody Background: EPHB6 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. Eph receptors and ephrin ligands are membrane-bound cell-cell communication molecules with well-defined functions...
Mouse monoclonal EphB6 antibody Background: The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A...
Mouse monoclonal Epithelial Sialomucin antibody Background: Epithelial Sialomucin is a mucin containing sialic acid. Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues...
Mouse monoclonal ER alpha antibody Background: The estrogen receptor (ESR) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative...
Mouse monoclonal ERBB2 antibody Background: ERBB2 is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal...
Mouse monoclonal ERBB3 antibody Background: ERBB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but...
Mouse monoclonal ERK 1/2 antibody Background: The ERKs (MAPK p42/p44) are the prototypic MAPKs and are activated by a variety of mitogenic stimuli as well as differentiation signals. MAPK activation...
Mouse monoclonal ERK2 antibody Background: MAPK1 acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription...
Mouse monoclonal ESPL1 antibody Background: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released...
Mouse monoclonal ESR1 antibody Background: ESR1 is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the...
Mouse monoclonal Estrogen Receptor antibody Background: Estrogen receptor refers to a group of receptors that are activated by the hormone estrogen. Two types of estrogen receptor exist: ER, which is...
Mouse monoclonal Estrogen Receptor antibody Background: The ER gene consists of more than 140 kb of genomic DNA divided into 8 exons, being translated into a protein with six functionally...
Mouse monoclonal ETS1 antibody Background: ETS transcriptions factors, such as ETS1, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS...
Mouse monoclonal ETS2 antibody Background: ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS...
Mouse monoclonal ETV1 antibody Background: ETV1 is a transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.
Mouse monoclonal ETV4 antibody Background: ETV4 is a transcriptional activator that binds to the enhancer of the adenovirus E1A gene.
Mouse monoclonal ETV5 antibody Background: ETV5 is expressed in Sertoli cells and spermatogonial stem cells (SSCs). Studies on knockout mice have shown that it is required for SSC self-renewal but...
Mouse monoclonal FABP4 antibody Background: FABP4 is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. FABP4 is thought to regulate fatty acid uptake, release, and storage in...
Mouse monoclonal Factor VIII antibody Background: Factor VIII is an essential blood clotting factor also known as anti-hemophilic factor (AHF). In humans, Factor VIII is encoded by the F8 gene.
Mouse monoclonal FAK antibody Background: FAK is a protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix...
Mouse monoclonal FANCG antibody Background: FANCG, involved in Fanconi anemia, confers resistance to both hygromycin and mitomycin C. FANCG contains a 5-prime GC-rich untranslated region characteristic of housekeeping genes. The...
Mouse monoclonal FBLN2 antibody Background: FBLN2 binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal...
Mouse monoclonal FBLN5 antibody Background: FBLN5 is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of...
Mouse monoclonal FEN1 antibody Background: The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA...
Mouse monoclonal FES antibody Background: FES is the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. FES has tyrosine-specific protein kinase activity and that activity is...
Mouse monoclonal FGB antibody Background: FGB is a gene found in humans and most other vertebrates with a similar system of blood coagulation. It is the beta component of fibrinogen,...
Mouse monoclonal FGF2 antibody Background: The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in...
Mouse monoclonal FGFR1 antibody Background: FGFR1 is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with...
Mouse monoclonal FGFR4 antibody Background: FGFR4 is part of a family of fibroblast growth factor receptors that mediate the biological functions of specific growth factors. Each receptor contains an extracellular...
Mouse monoclonal Fibronectin antibody Background: Fibronectin is a high-molecular weight (~440 kDa) extracellular matrix glycoprotein that binds to membrane-spanning receptor proteins called integrins. In addition to integrins, fibronectin also binds...
Mouse monoclonal Fibulin 5 antibody Background: Fibulin 5 is a recently discovered multifunctional extracellular matrix protein that mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in...
Mouse monoclonal FLAG antibody Background: The FLAG antibody recognizes the FLAG epitope located on FLAG-tagged fusion proteins at the N-terminus or C-terminus, applying dot blot, immunoblotting, immunoprecipitation and immunocytochemistry assays.
Mouse monoclonal Flt1 antibody Background: Fms-related tyrosine kinase 1 is a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which...
Mouse monoclonal FLT4 antibody Background: FLT4 is a protein which in humans is encoded by the FLT4 gene. This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors...
Mouse monoclonal FOSL1 antibody Background: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of...
Mouse monoclonal FOSL2 antibody Background: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of...
Mouse monoclonal FOXA2 antibody Background: FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and...
Mouse monoclonal FOXP3 antibody Background: FOXP3 (forkhead box P3) is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to function as a...
Mouse monoclonal FRK antibody Background: FRK belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of...
Mouse monoclonal FRK antibody Background: FRK is an epithelial tissue-specific kinase. The human FRK gene maps to chromosome 6q21-q22. 3 and encodes a 505 amino acid protein. The protein belongs...
Mouse monoclonal GABPA antibody Background: GABPA is one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding...
Mouse monoclonal GATA2 antibody Background: The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic...
Mouse monoclonal GATA3 antibody Background: GATA3 belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T cell development...
Mouse monoclonal GATA4 antibody Background: Transcription factor GATA4 is a protein that in humans is encoded by the GATA4 gene. This gene encodes a member of the GATA family of...
Mouse monoclonal GATAD1 antibody Background: GATAD1 (GATA zinc finger domain-containing protein 1), also known as ODAG (ocular development-associat ed gene protein), is a 269 amino acid protein that is involved...
Mouse monoclonal GCN5L2 antibody Background: The protein encoded by the GCN5L2 gene has been shown to interact with Ku70, TAF9, Transcription initiation protein SPT3 homolog, TADA2L, Ku80and DDB1.
Mouse monoclonal GFAP antibody Background: GFP is an intermediate filament. GFP and vimentin are linked to the same filament network; they are localized in the same filaments. mRNAs encoding the...
Mouse monoclonal GFI1 antibody Background: GFI1 functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a...
Mouse monoclonal GFP antibody Background: Green Fluorescent Protein (GFP) tagging provide an excellent means for monitoring gene expression and protein localization in living cells, so that it is widely accepted...
Mouse monoclonal GLP1 antibody Background: GLP1 is an incretin hormone secreted from enteroendocrine L cells in response to ingested nutrients. The closely related peptides glucagon-like peptide and glucagon have opposing...
Mouse monoclonal GSK3 alpha antibody Background: Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily; GSK3 subsubfamily. It is implicated in the hormonal control...
Mouse monoclonal GSK3B antibody Background: Glycogen synthase kinase 3 beta is a serine/threonine kinase involved in insulin, growth factor and Wnt signaling. Glycogen synthase kinase 3 beta (GSk3beta) is a...
Mouse monoclonal GST antibody Background: Glutathione S transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic...
Mouse monoclonal GSTP1 antibody Background: Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds...
Mouse monoclonal GTF2B antibody Background: GTF2B encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the...
Mouse monoclonal GTF2I antibody Background: This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by...
Mouse monoclonal HAND1 antibody Background: HAND1 belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which...
Mouse monoclonal HAS1 antibody Background: HAS1 is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the...
Mouse monoclonal HAUSP antibody Background: USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated...
Mouse monoclonal HCK antibody Background: HCK is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation...
Mouse monoclonal HDAC3 antibody Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetyl ation alters chromosome structure and affects transcription factor access...
Mouse monoclonal HDAC4 antibody Background: HDAC4 belongs to class II of the histone deacetylase/acuc/aph a family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This...
Mouse monoclonal HER2 antibody Background: HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. It...
Mouse monoclonal HK1 antibody Background: The hexokinases utilize Mg-ATP as a phosphoryl donor to catalyze the first step of intracellular glucose metabolism, the conversion of glucose to glucose- 6-phosphate. Four...
Mouse monoclonal HK2 antibody Background: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. HK2 (hexokinase 2) is the predominant form found in skeletal muscle. It...
Mouse monoclonal HMBOX1 antibody Background: This gene represents a transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as a transcriptional repressor.
Mouse monoclonal HMG20A antibody Background: This gene plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST...
Mouse monoclonal HNRPLL antibody Background: HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45, a tyrosine phosphatase essential for T-cell...
Mouse monoclonal HOXA3 antibody Background: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four...
Mouse monoclonal HOXA6 antibody Background: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four...
Mouse monoclonal HOXC10 antibody Background: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role...
Mouse monoclonal HPRT antibody Background: HPRT is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl...
Mouse monoclonal HPRT antibody Background: HPRT1 has a central role in the generation of purine nucleotides through the purine salvage pathway. HPRT1 catalyzes conversion of hypoxanthine to inosine monophosphate and...
Mouse monoclonal HPS1 antibody Background: HPS1 may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is a component of three different...
Mouse monoclonal HRP antibody Background: Horseradish peroxidase is a 44,173. 9-dalton glycoprotein with 4 lysine residues for conjugation to a labeled molecule. It produces a coloured, fluorimetric, or luminescent derivative...
Mouse monoclonal HTATIP2 antibody Background: This gene encodes an oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset...
Mouse monoclonal Human Ig kappa antibody Background: Kappa light chain is an IgG/IgA light chain 23 kDa protein from an oligoclonal pool. This is the earliest tumour marker of paraproteins...
Mouse monoclonal Human Ig lambda antibody Background: This 23 kDa protein, along with kappa light chains, is the earliest paraprotein tumour marker seen in urine.
Mouse monoclonal Human IgA antibody Background: IgA is the most abundant immunoglobulin in body fluids and the second most abundant immunoglobulin in plasma, found at a concentration of 0.4 to...
Mouse monoclonal Human IgE antibody Background: IgE is the least abundant immunoglobulin in plasma, found at a concentration of less that 0.6 micrograms/ml of normal plasma. Elevated IgE levels are...
Mouse monoclonal Human IgG antibody Background: IgG is the most abundant immunoglobulin in plasma, found at a concentration of 8 to 18 mg/ml. This immunoglobulin plays a very important role...
Mouse monoclonal human IgG antibody Background: Immunoglobulin G (IgG) are antibody molecules. Each IgG is composed of four peptide chains - two heavy chains and two light chains. Each IgG...
Mouse monoclonal Human IgM antibody Background: IgM is found in normal plasma at a concentration of 1.2 to 4.0 mg/ml. It is the first immunoglobulin produced during the immune response,...
Mouse monoclonal ICAM1 antibody Background: ICAMs are members of the Ig superfamily of calcium-independent transmembrane glycoproteins. ICAM1 is a ligand for lymphocyte function-associated (LFA) and Mac-1 integrins and the major...
Mouse monoclonal IFI35 antibody Background: The function of this gene has not been determined.
Mouse monoclonal IFN gamma antibody Background: Human IFN-gamma is a 17 kDa factor produced by activated T and NK cells and is an anti-viral and anti-parasitic cytokine. IFN-gamma in synergy...
Mouse monoclonal IGF1R antibody Background: IGF1R binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-likegrowth factor I receptor plays a critical role in transformation...
Mouse monoclonal IGFBP2 antibody Background: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on...
Mouse monoclonal IHOG antibody Background: The IHOG gene, identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response...
Mouse monoclonal IKBKB antibody Background: IKBKB is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by...
Mouse monoclonal IKBKE antibody Background: IKBKE is a noncanonical I-kappa-B kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer oncogene...
Mouse monoclonal IL16 antibody Background: IL16 is a chemotactic cytokine that stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils through binding to the CD4 receptor . IL-16 induces...
Mouse monoclonal IL1a antibody Background: IL1a is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL1a and IL1beta...
Mouse monoclonal IL6 antibody Background: IL6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts,...
Mouse monoclonal IL8 antibody Background: IL8 is an interleukin (chemokine) produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store...
Mouse monoclonal Influenza A Virus Nucleoprotein antibody Background: The nucleoprotein (NP) of Influenza virus encapsulates the negative strand of the viral RNA and is essential for replicative transcription. It may...
Mouse monoclonal Influenza B Virus Nucleoprotein antibody Background: Influenza virus B is a genus in the virus family Orthomyxoviridae. A limited host range means that Influenza virus B pandemics are...
Mouse monoclonal INHA antibody Background: INHA joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal...
Mouse monoclonal Inhibin alpha antibody Background: INHA joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal...
Mouse monoclonal IRF2 antibody Background: IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons...
Mouse monoclonal ISL1 antibody Background: ISL1 is a member of the LIM/homeodomain family of transcription factors. It binds to the enhancer region of the insulin gene, among others, and may...
Mouse monoclonal ISL2 antibody Background: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways By similarity.
Mouse monoclonal ITK antibody Background: ITK is an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It...
Mouse monoclonal JAK2 antibody Background: JAK2 is a human protein that has been implicated in signaling by members of the type II cytokine receptor family, the GM-CSF receptor family (IL-3R,...
Mouse monoclonal KCMF1 antibody Background: This gene has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.
Mouse monoclonal Keratin K10 antibody Background: Keratin-10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric...
Mouse monoclonal Keratin K13 antibody Background: Keratin 13 is a protein that in humans is encoded by the KRT13 gene. Keratin 13 is a type I cytokeratin, it is paired...
Mouse monoclonal Keratin K14 antibody Background: Keratin, type I cytoskeletal 14 is a protein that in humans is encoded by the KRT14 gene. Keratin 14 is a type I keratin.
Mouse monoclonal Keratin K18 antibody Background: Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found product of the...
Mouse monoclonal Keratin K19 antibody Background: Keratin K19 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and...
Mouse monoclonal Keratin K5 antibody Background: Keratin K5 is a member of the keratin gene family. Biochemically, most members of the CK family fall into one of two classes, type...
Mouse monoclonal Keratin K5/K8 Pan Epithelial antibody Background: Keratin K5 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are...
Mouse monoclonal Keratin K8 antibody Background: Keratin 8 is a keratin protein that in human is encoded by the KRT8 gene. It is often paired with keratin 18.
Mouse monoclonal KI67 antibody Background: KI67 is a nuclear protein, which is expressed in proliferating cells. Ki-67 is preferentially expressed during late G1-, S-, M-, and G2-phases of the cell...
Mouse monoclonal KIAA0863 antibody Background: This gene may be involved in transcriptional regulation.
Mouse monoclonal KIAA1443 antibody Background: This gene may function as a transcriptional regulator.
Mouse monoclonal KLF15 antibody Background: KLF15 contains 3 zinc finger motifs at its C terminus, N-terminal serine-rich stretches, and a central proline-rich segment. KLF15, a kidney-enriched Krueppel-like factor, is a...
Mouse monoclonal KLF4 antibody Background: KLF4 is a zinc finger-containing transcription factor that belongs to the kruppel-like family of transcription factors. kLF4 plays important roles during the proliferation and differentiation...
Mouse monoclonal KLF4 antibody Background: Kruppel-like factor 4 (gut),endothelial Kruppel-like zinc finger protein. May act as a transcriptional activator. Binds the CACCC core sequence. May be involved in the differentiation...
Mouse monoclonal KLHL1 antibody Background: KLHL1 was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues. The predicted protein domain structure...
Mouse monoclonal KLHL12 antibody Background: KLHL12 serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. It negatively regulates the Wnt signaling pathway via the targeted ubiquitination and...
Mouse monoclonal KLHL21 antibody Background: KLHL21 is a probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Mouse monoclonal KLHL22 antibody Background: KLHL22 is Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for cell division. BCR E3 ubiquitin ligase complexes mediate the ubiquitination of...
Mouse monoclonal KLHL25 antibody Background: KLHL25 is a cytoplasmic protein that contains six Kelch regions and a single BTB (POZ) domain. KLHL25 is highly homologus to another Kelch-like protein, ENC1,...
Mouse monoclonal KSHV K8 alpha antibody Background: Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesviru s subfamily and has been closely linked to the Kaposi?s sarcoma, primary effusion lymphoma (PEL)...
Mouse monoclonal KSHV ORF26 antibody Background: Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesviru s subfamily and has been closely linked to the Kaposi?s sarcoma, primary effusion lymphoma (PEL) and...
Mouse monoclonal KSHV ORF45 antibody Background: Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesviru s subfamily and has been closely linked to the Kaposi?s sarcoma, primary effusion lymphoma (PEL) and...
Mouse monoclonal KSHV ORF62 antibody Background: Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesviru s subfamily and has been closely linked to the Kaposi?s sarcoma, primary effusion lymphoma (PEL) and...
Mouse monoclonal LAL antibody Background: LAL functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides which are taken up by receptor-mediated endocytosis. An inherited deficiency or...
Mouse monoclonal Laminin antibody Background: Laminins are major proteins in the basal lamina, a protein network foundation for most cells and organs. The laminins are an important and biologically active...
Mouse monoclonal LARS2 antibody Background: This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or...
Mouse monoclonal LCK antibody Background: LCK is a member of the Src family of protein tyrosine kinases (PTKs). It is a key signaling molecule in the selection and maturation of...
Mouse monoclonal LPIN2 antibody Background: Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a...
Mouse monoclonal LPL antibody Background: LPL is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor...
Mouse monoclonal LRRFIP2 antibody Background: This gene may function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin.
Mouse monoclonal LSD1 antibody Background: LSD1 is the first of several protein lysine demethylases discovered. Through a FAD-dependent oxidative reaction, LSD1 speficially removes histone H3K4me2 to H3K4me1 or H3K4me0. When...
Mouse monoclonal LSM5 antibody Background: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins contain the Sm sequence motif,...
Mouse monoclonal Lung Cancer Marker MOC 1 antibody Background: MOC-1 reacts with 125 kD and 145 kD membrane-associated proteins in normal and malignant neu-roendocrine tissues including small cell lung cancer.
Mouse monoclonal Lung Cancer Marker MOC 21 antibody Background: MOC-21 reacts with membrane-associated proteins of 120 kD, 125 kD and 145 kD in normal and malignant tis-sue, including a subgroup...
Mouse monoclonal Lung Cancer Marker MOC 32 antibody Background: MOC-32 reacts with a membrane-associated protein present in normal and malignant neuroendocrine tissues including a subgroup of small cell lung cancer.
Mouse monoclonal Lung Cancer Marker MOC 52 antibody Background: MOC-52 reacts with a membrane-associated protein present in normal and malignant neuroendocrine tissues including small cell lung cancer. A positive reaction...
Mouse monoclonal LYN antibody Background: Lyn is a membrane associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and...
Mouse monoclonal Mammaglobin 1 antibody Background: Mammaglobin is a gene that is expressed almost exclusively in the normal breast epithelium and human breast cancer. It is a member of the...
Mouse monoclonal MAP2K4 antibody Background: MAP2K4 is a a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is adirect activator of MAP kinases in...
Mouse monoclonal MAP4K4 antibody Background: MAP4K4 is the serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. MAP4K4 appears to act...
Mouse monoclonal MAPK11 antibody Background: MAPK11 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a...
Mouse monoclonal MATK antibody Background: the MATK protein has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and...
Mouse monoclonal MBIP antibody Background: This protein encoded by this gene inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. It is a component of the ATAC...
Mouse monoclonal MBP antibody Background: Myelin Basic Protein (MBP) functions in the nervous system in myelination and is expressed in oligodendrocytes following differentiation. There are numerous isoforms generated by differential...
Mouse monoclonal MCL1 antibody Background: MCL1 is a protein which belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been...
Mouse monoclonal MCP1 antibody Background: The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP1, other CCR receptors. The MCP proteins...
Mouse monoclonal MER antibody Background: MER is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like )...
Mouse monoclonal MESP1 antibody Background: MESP1 is a basic helix-loop-helix-typ e transcription factor, which along with its related proteins, has an essential role in both segmentation and rostro-caudal patterning of...
Mouse monoclonal MIS12 antibody Background: This gene forms part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis.
Mouse monoclonal MLL antibody Background: MLL contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which...
Mouse monoclonal MPS1 antibody Background: MPS1 belongs to the S27E family of ribosomal proteins. It contains a C4-type zinc finger domain that can bind to zinc and has been shown...
Mouse monoclonal MSH2 antibody Background: The MSH2 gene is one of 4 known genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in...
Mouse monoclonal MSH6 antibody Background: Defects in MSH6 are a cause of hereditary non-polyposis colorectal cancer (HNPCC) (Lynch syndrome). HNPCC is an autosomal, dominantly inherited disease associated with marked increase...
Mouse monoclonal MST1R antibody Background: MST1R is a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulati ng protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth,...
Mouse monoclonal Mucin 1 antibody Background: Mucins are heavily glycosylated proteins which constitute the major components of mucus covering the surface of epithelial tissues. Nine distinct epithelial mucin genes (Muc-1,...
Mouse monoclonal Mucin 2 antibody Background: Mucins are heavily glycosylated proteins which constitute the major components of mucus covering the surface of epithelial tissues. Nine distinct epithelial mucin genes (Muc-1,...
Mouse monoclonal Mucin antibody Background: Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most metazoans. Mucins' key characteristic is their ability...
Mouse monoclonal MUM1 antibody Background: MUM1 is a 78 kDa protein encoded by the MUM1 gene. MUM1 is expressed in a subset of B cells in the light zone of...
Mouse monoclonal MuSK antibody Background: MuSK is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate...
Mouse monoclonal MYC antibody Background: Myc (c-Myc) codes for a protein that binds to the DNA of other genes and is therefore a transcription factor. When a gene like Myc...
Mouse monoclonal MYCBP antibody Background: The MYCBP gene encodes a protein that binds to the N-terminal region of MYC (MIM 190080) and stimulates the activation of E box-dependent transcription by...
Mouse monoclonal Myelin antibody Background: Myelin is a dielectric (electrically insulating) material that forms a layer, the myelin sheath, usually around only the axon of a neuron. It is essential...
Mouse monoclonal Myeloperoxidase antibody Background: Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor,...
Mouse monoclonal MYL3 antibody Background: MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal...
Mouse monoclonal MYOD1 antibody Background: MYOD1 belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest,...
Mouse monoclonal Myostatin antibody Background: Myostatin is a TGF beta family member that acts as an inhibitor of skeletal muscle growth. This muscle-specific cytokine interacts with Activin type I and...
Mouse monoclonal MYST1 antibody Background: The MYST family of histone acetyltransferases, which includes MYST1, is named for the founding members MOZ (MYST3; MIM 601408), yeast YBF2 and SAS2, and TIP60...
Mouse monoclonal MYST2 antibody Background: This gene is a component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible...
Mouse monoclonal MYST4 antibody Background: Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. It is required for RUNX2-dependent transcriptional activation. May be involved in...
Mouse monoclonal Nanog antibody Background: The transcriptional factor Nanog functions in maintaining pluripotency in cooperation with other key genes such as Oct4. Oct4 and Sox2 bind to the Nanog promoter...
Mouse monoclonal NCAM antibody Background: Neural Cell Adhesion Molecule is a homophilic binding glycoprotein expressed on the surface of neurons, glia, skeletal muscle and natural killer cells. NCAM has been...
Mouse monoclonal NCBP2 antibody Background: The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA...
Mouse monoclonal NCOA3 antibody Background: NCOA3 is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. NCOA3 has histone acetyltransferase activity and recruits...
Mouse monoclonal NCOR1 antibody Background: NCOR1 mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of...
Mouse Monoclonal NELL2 antibody Background: Protein kinase C-binding protein, NELL2 is expressed abundantly in neural tissues and may play important roles in the development of neural tissues. Also, NELL protein...
Mouse monoclonal neu-Oncogene antibody Background: neu-Oncogene reacts with the 185 kD protein in immunoblot-ting. The c-erbB2 proto-oncogene codes for a membrane protein. Several studies report the amplification in carcinomas. Overexpression...
Mouse monoclonal Neurogenin 3 antibody Background: Neurogenin 3 is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine. It belongs to a...
Mouse monoclonal NFKB p65 antibody Background: NFkB-p65 a subunit of NF-kappa-B transcription complex, which plays a crucial role in inflammatory and immune responses. The inhibitory effect of I-kappa-B upon NF-kappa-B...
Mouse monoclonal NFKBIB antibody Background: NFKBIB inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B...
Mouse monoclonal NGRN antibody Background: This gene may be involved in neuronal differentiation.
Mouse monoclonal NIP7 antibody Background: This gene is required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly (By similarity).
Mouse monoclonal NKRF antibody Background: This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes.
Mouse monoclonal NKX2.5 antibody Background: NKX2. 5 is a homeobox-containing transcription factor. This transcription factor functions in cardiac formation and development. Mutations in this gene cause atrial septal defect with...
Mouse monoclonal NKX3A antibody Background: The homeodomain-containi ng transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3A...
Mouse monoclonal NMNAT1 antibody Background: The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some...
Mouse monoclonal NPEPPS antibody Background: This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to...
Mouse monoclonal NPT antibody Background: NPT is used in selection of transformed organisms. It was initially isolated from the transposon Tn5 that was present in the bacterium strain Escherichia coli...
Mouse monoclonal NT5E antibody Background: NT5E catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of...
Mouse monoclonal NTRK3 antibody Background: NTRK3 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and...
Mouse monoclonal Nucleophosmin antibody Background: Nucleophosmin is a nucleolar phosphoprotein that binds the tumor suppressors p53 and p19Arf and is thought to be indispensable for ribogenesis, cell proliferation, and survival...
Mouse monoclonal OCT4 antibody Background: OCT4 modulates embryonic stem (ES) cell populations by influencing lineage commitment. Oct-3/4 pseudogenes localizing to human chromosomes 10 and 8 are reported to be transcribed...
Mouse monoclonal OSTF1 antibody Background: Osteoclast-stimulati ng factor (OSTF1) is an intracellular signaling protein, highly expressed by osteoclasts(OCL). Indirectly, it enhances osteoclast (OCL) formation and bone resorption through a cellular...
Mouse monoclonal OVA antibody Background: OVA is used in variety of laboratories products which contain OVA as a carrier protein. To raise antibodies against small non-immunogenic molecules,called haptens,it is often...
Mouse monoclonal OVOL1 antibody Background: This gene encodes a protein highly similar to Drosophila and mouse proteins. In Drosophila the ovo protein plays a critical role in Drosophila oogenesis and...
Mouse monoclonal P11 antibody Background: P11 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of...
Mouse monoclonal P16 antibody Background: Cyclin-dependent kinase inhibitor 2A is a tumor suppressor protein, which in humans is encoded by the CDKN2A gene. P16 plays an important role in regulating...
Mouse monoclonal p16 antibody Background: p16 is a tumor suppressor protein, which in humans is encoded by the CDKN2A gene. p16 plays an important role in regulating the cell cycle,...
Mouse monoclonal p34cdc 2 antibody Background: The antibody detects the three bands within the 34kD region corresponding to the p34 protein and it's cleavage products. P34cdc-2 is activated and initiates...
Mouse monoclonal PAK2 antibody Background: Serine/threonine-pro tein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene. The p21 activated kinases (PAK) are critical effectors...
Mouse monoclonal Pan B Cell Antigen CD20 antibody Background: B-lymphocyte antigen CD20 or CD20 is an activated-glycosylat ed phosphoprotein expressed on the surface of all mature B-cells. In humans CD20...
Mouse monoclonal PAR1 antibody Background: Protease-activated receptors are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain. They are highly expressed...
Mouse monoclonal PAR4 antibody Background: PAR4 (for prostate apoptosis response) is a WT1-interacting protein that also functions as a transcriptional repressor. PAR4 contains a putative leucine zipper domain and is...
Mouse monoclonal PARL antibody Background: PARL is a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This...
Mouse monoclonal PARP4 antibody Background: This gene encodes poly(ADP-ribosyl)tra nsferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ati on reaction. This protein has a catalytic domain which is homologous...
Mouse monoclonal PAX6 antibody Background: PAX6 is the most researched of the PAX genes and appears throughout the literature as a "master control" gene for the development of eyes and...
Mouse monoclonal PAX8 antibody Background: PAX8 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired...
Mouse monoclonal PBEF1 antibody Background: PBEF1 catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-p yrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein is...
Mouse monoclonal PBX2 antibody Background: This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved...
Mouse monoclonal PCNA antibody Background: Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase delta in eukaryotic cells. It...
Mouse monoclonal PDCD11 antibody Background: PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation...
Mouse monoclonal PDGFr beta antibody Background: Platelet derived growth factor receptor (PDGF Receptor) is a transmembrane glycoprotein of 170-185 kDa which undergoes homo or heterodimerization into complexes of alpha and...
Mouse monoclonal PEG10 antibody Background: PEG10 includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence...
Mouse monoclonal PGR antibody Background: PGR is a member of the steroid receptor superfamily. The PGR protein mediates the physiological effects of progesterone, which plays a central role in reproductive...
Mouse monoclonal PKLR antibody Background: PKLR is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. The PKLR gene...
Mouse monoclonal PML antibody Background: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a...
Mouse monoclonal POLDIP2 antibody Background: This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. The encoded protein also interacts with proliferating cell nuclear antigen. Some...
Mouse monoclonal POLR2I antibody Background: This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other...
Mouse monoclonal POLR3E antibody Background: This gene complements a temperature-sensitiv e mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1...
Mouse monoclonal POLR3K antibody Background: This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal...
Mouse monoclonal PP32 antibody Background: PP32 is implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase...
Mouse monoclonal PPARG antibody Background: PPARG is a member of the peroxisome proliferator-activat ed receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these...
Mouse monoclonal PPM1D antibody Background: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative...
Mouse monoclonal PPP1A antibody Background: PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen...
Mouse monoclonal PR antibody Background: PR is a member of the steroid receptor superfamily and mediates the physiologic effects of progesterone, PR is mediated by two functionally different isoforms of...
Mouse monoclonal PRAK antibody Background: PRAK is an ubiquitously expressed serine/threonine kinase regulated by p38 alpha and p38 beta MAP kinases. Phosphorylation of PRAK occurs in vivo in response to...
Mouse monoclonal PRDM1 antibody Background: PRDM1 is a repressor of beta-interferon gene expression. This action is exerted by binding to the PRDI (positive regulatory domain I element) of the beta-IFN...
Mouse monoclonal PRMT6 antibody Background: Protein arginine N-methyltransferases , such as PRMT6, catalyze the sequential transfer of a methyl group from S-adenosyl-L-methion ine to the side chain nitrogens of arginine...
Mouse monoclonal Progesterone Receptor antibody Background: The progesterone receptor is an intracellular steroid receptor that specifically binds progesterone. In humans, PR is encoded by a single PGR gene residing on...
Mouse monoclonal Proteinase 3 antibody Background: Proteinase 3 also known as PRTN3 is an enzyme which in humans is encoded by the PRTN3 gene. PRTN3 is a serine protease enzyme...
Mouse monoclonal PROZ antibody Background: PROZ appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles.
Mouse monoclonal PSF3 antibody Background: PSF3 is one of the members of the GINS complex (other members being PSF1, PSF2 and SLD5) which is vital in the generation of replication...
Mouse monoclonal PTH antibody Background: PTH is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion.
Mouse monoclonal PTK6 antibody Background: The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues.
Mouse monoclonal PTK7 antibody Background: Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles...
Mouse monoclonal R spondin1 antibody Background: R spondin1 is a member of the R-spondin family and a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1...
Mouse monoclonal RAB10 antibody Background: RAB10 belongs to the RAS superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking.
Mouse monoclonal RAB25 antibody Background: RAB proteins, such as RAB25, are members of the RAS superfamily of small GTPases that are involved in membranetrafficking. Members of the RAB11 subfamily, including...
Mouse monoclonal Ractopamine antibody Background: Ractopamine is a phenolethanolamine beta-adrenoceptor agonist that is used for the improvement of weight gain, carcass leanness and feed efficiency in pigs. It has been...
Mouse monoclonal RAG2 antibody Background: RAG2 is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the...
Mouse monoclonal RAS antibody Background: The Ras protein is a subfamily of small GTPases that are involved in signal transduction. They are activated by ligand-binding receptor tyrosine kinases such as...
Mouse monoclonal RB antibody Background: The RB protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated...
Mouse monoclonal REG1A antibody Background: Lithostathine-1-alph a is a protein that in humans is encoded by the REG1A gene. This gene is a type I subclass member of the Reg...
Mouse monoclonal Ret antibody Background: Ret is a receptor tyrosine kinase that functions as a multicompetent receptor complex in conjunction with other membrane-bound ligand-binding GDNF family receptors. Ligands that bind...
Mouse monoclonal RICTOR antibody Background: RICTOR and MTOR are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth.
Mouse monoclonal ROR1 antibody Background: ROR1 is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response...
Mouse monoclonal RPS6KA4 antibody Background: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates...
Mouse monoclonal RRAGC antibody Background: RRAGC is a monomeric guanine nucleotide-binding protein encoded by the RRAGC gene. By binding GTP or GDP, small G proteins act as molecular switches in...
Mouse monoclonal RREB1 antibody Background: The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown...
Mouse monoclonal Rsk1 antibody Background: Rsk1 contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of themitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has...
Mouse monoclonal RTN3 antibody Background: RTN3 may be involved in membrane trafficking in the early secretory pathway. It is thought to inhibit BACE1 activity and amyloid precursor protein processing. It...
Mouse monoclonal S100A1 antibody Background: S100A1 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and nucleus of...
Mouse monoclonal S100B antibody Background: S100B is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of...
Mouse monoclonal SAE1 antibody Background: The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of...
Mouse monoclonal SARS E2 antibody Background: SARS is caused by a human coronavirus. Human coronaviruses are the major cause of upper respiratory tract illness, such as the common cold, in...
Mouse monoclonal SARS M antibody Background: SARS is caused by a human coronavirus. Human coronaviruses are the major cause of upper respiratory tract illness, such as the common cold, in...
Mouse monoclonal SATB1 antibody Background: The protein encoded by this gene binds to DNA at special AT-rich sequences at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure...
Mouse monoclonal SCGB2A2 antibody Background: Mammaglobin is expressed almost exclusively in the normal breast epithelium and human breast cancer. It is a member of the secretoglobin gene family and forms...
Mouse monoclonal SCML1 antibody Background: This gene encodes the Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state...
Mouse monoclonal SEPT11 antibody Background: SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking.
Mouse monoclonal SESN2 antibody Background: This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival.
Mouse monoclonal SETD7 antibody Background: This gene encodes a histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays...
Mouse monoclonal SH3BP4 antibody Background: This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation...
Mouse monoclonal SHH antibody Background: Sonic the hedgehog homolog (SHH) is one of three proteins in the mammalian signaling pathway family called hedgehog, the others being desert hedgehog (DHH) and...
Mouse monoclonal SHPRH antibody Background: SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of...
Mouse monoclonal SKP2 antibody Background: SKP2 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute...
Mouse monoclonal SLC2A4RG antibody Background: The protein encoded by this gene is a nuclear transcription factor involved in the activation of the solute carrier family 2 member 4 gene. The...
Mouse monoclonal Smoothelin antibody Background: Smoothelin is a protein that in humans is encoded by the SMTN gene. Smoothelin is found exclusively in contractile smooth muscle cells. It associates with...
Mouse monoclonal SNAI2 antibody Background: SNAI2 is a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to...
Mouse monoclonal SNAPC5 antibody Background: This gene forms part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the...
Mouse monoclonal SNCA antibody Background: SNCA belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed...
Mouse monoclonal SNCG antibody Background: Gamma-synuclein (originally known as a breast cancer specific gene product, BCSG1) is an acidic neuronal protein of 127 amino acids. The protein coding region of...
Mouse monoclonal SND1/P100 antibody Background: SND1/P100 functions in the Pim-1 regulation of Myb activity and acts as a transcriptional activatior of EBNA-2. It also interacts with EAV, NSP1,GTF2E1 and GTF2E2,...
Mouse monoclonal SNRPD3 antibody Background: The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein...
Mouse monoclonal SORL1 antibody Background: SORL1 is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into...
Mouse monoclonal SOX2 antibody Background: Transcription factor SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the...
Mouse monoclonal SOX5 antibody Background: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination...
Mouse monoclonal SOX6 antibody Background: The SOX gene family encodes a group of transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX...
Mouse monoclonal SRA antibody Background: SRA belongs to the growing family of functional non-coding RNAs. SRA was originally described as the first functional noncoding RNA able to specifically coactivate the...
Mouse monoclonal SRC antibody Background: SRC may play a role in the regulation of embryonic development and cell growth. The SRC protein is a tyrosine-protein kinase whose activity can be...
Mouse monoclonal SRF antibody Background: This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is amember of the MADS (MCM1, Agamous, Deficiens, and SRF)...
Mouse monoclonal SSNA1 antibody Background: This gene encodes Sjogren syndrome nuclear autoantigen 1.
Mouse monoclonal ST13 antibody Background: ST13 is one of several co-chaperones that regulate activities of the HSP70 chaperone family. The homo-oligomeric protein Hip cooperates with HSP70 in protein folding by...
Mouse monoclonal STAMBPL1 antibody Background: this gene encodes a zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. It does not cleave 'Lys-48'-linked polyubiquitin chains
Mouse monoclonal STAT1 antibody Background: STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a...
Mouse monoclonal STAT3 antibody Background: STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated...
Mouse monoclonal STAT5B antibody Background: STAT5B is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the...
Mouse monoclonal STK38L antibody Background: This gene is involved in the regulation of structural processes in differentiating and mature neuronal cells.
Mouse monoclonal STYK1 antibody Background: STYK1 is a protein kinase widely expressed in human tissues.
Mouse monoclonal Survivin antibody Background: Survivin is a human gene encoding a structurally unique IAP apoptosis inhibitor. Present during fetal development, survivin is undetectable in terminally differentiated adult tissues. However,...
Mouse monoclonal SYK antibody Background: SYK is a non-receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including...
Mouse monoclonal SYP antibody Background: Synaptophysin is an integral membrane protein of small synaptic vesicles in brain and endocrine cells. Synaptophysin contains four transmembrane domains that form a hexameric channel...
Mouse monoclonal SYT1 antibody Background: Synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to...
Mouse monoclonal T Cell Antigen CD43 antibody Background: CD43 is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be...
Mouse monoclonal T Cell Antigen CD45RO antibody Background: CD45 is a protein tyrosine phosphatase (PTP) located in hematopoietic cells except ethrocytes and platelets. The protein tyrosine kinases constitute a family...
Mouse monoclonal T Cell Antigen CD8 antibody Background: CD8 is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to...
Mouse monoclonal TAB2 antibody Background: TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a...
Mouse monoclonal TAF1B antibody Background: Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific...
Mouse monoclonal TAF5L antibody Background: The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF...
Mouse monoclonal TBL1X antibody Background: TBL1X is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelia...
Mouse monoclonal TBX5 antibody Background: TBX5, also known as T-box 5. It is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box.
Mouse monoclonal TEC antibody Background: TEC belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms...
Mouse monoclonal Tenascin antibody Background: Tenascin/hexabrachio n/cytotactin is an extracellular matrix glycoprotein, widely expressed during embryogenesis. In adults, it is restricted to certain epithelial-stromal interfaces and increases markedly in hyperproliferative...
Mouse monoclonal TGF beta 1 antibody Background: TGF beta is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. In mammals, three isoforms of TGFbeta,...
Mouse monoclonal Thyroglobulin antibody Background: Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. In earlier literature, Tg was referred to as...
Mouse monoclonal TIP60 antibody Background: TIP60 belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in...
Mouse monoclonal TLR2 antibody Background: Toll-like receptor 2 (TLR2) has been shown to mediate the innate immune response to ligands derived from a variety of pathogens, including Gram-positive bacteria, Mycoplasma,...
Mouse monoclonal Tnk1 antibody Background: Tnk1 is a nonreceptor tyrosine kinase. These kinases, like members of the SRC and JAK families, mediate intracellular signaling downstream of receptor activation. Tnk1 is...
Mouse monoclonal TRAFD1 antibody Background: The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses.
Mouse monoclonal TRIM5 alpha antibody Background: TRIM5 alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from...
Mouse monoclonal TUBB1 antibody Background: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at...
Mouse monoclonal Tubulin antibody Background: Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are alpha-tubulin and Beta-tubulin,...
Mouse monoclonal TUG antibody Background: The TUG protein contains a UBX domain, for GLUT4. In truncated form, TUG acts in a dominant-negative manner to inhibit insulin-stimulated GLUT4 redistribution in Chinese...
Mouse monoclonal Tyk2 antibody Background: Tyk2 belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum...
Mouse monoclonal Tyro 3 antibody Background: Tyro 3 belongs to the Axl/Tyro 3 family of receptor tyrosine kinases, which also includes Axl and Mer. Gas6 (growth arrest-specific gene-6) is a...
Mouse monoclonal TYRO3 antibody Background: TYRO3 belongs to the Tyr protein kinase family (AXL/UFO subfamily). The UFO family of receptor tyrosine kinases is comprised of subfamily members Rse(also referred to...
Mouse monoclonal UBE1L antibody Background: The modification of proteins with ubiquitin is an important cellular mechanism for targeting.
Mouse monoclonal USP39 antibody Background: This gene may play a role in mRNA splicing. It is unsure if the protein really exhibits hydrolase activity. Could be a competitor of ubiquitin...
Mouse monoclonal UTP11L antibody Background: This gene is involved in nucleolar processing of pre-18S ribosomal RNA.
Mouse monoclonal UTP18 antibody Background: This gene is involved in nucleolar processing of pre-18S ribosomal RNA.
Mouse monoclonal Vimentin antibody Background: Vimentin is one of the five major groups of intermediate filaments, a distinct class of cytosekeltal proteins, occurring in mesenchymal cells. Localized vimentin can be...
Mouse monoclonal Vimentin antibody Background: Vimentin is one of the five major groups of intermediate filaments, a distinct class of cytoskeletal proteins, occurring in mesenchymal cells. Localized vimentin can be...
Mouse monoclonal Visfatin antibody Background: Visfatin is a 55 kDa protein produced and secreted primarily by white adipose tissue. Recently, Visfatin was isolated from visceral fat deposits and shown to...
Mouse monoclonal WDR5 antibody Background: WDR5, also designated BMP-2-induced gene 3 kb or BIG-3, belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene...
Mouse monoclonal WNT10B antibody Background: WNT10B is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch...
Mouse monoclonal WNT5A antibody Background: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental...
Mouse monoclonal XBP1 antibody Background: This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This...
Mouse monoclonal YES1 antibody Background: YES1 has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome...
Mouse monoclonal ZBTB16 antibody Background: ZBTB16 is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains...
Mouse monoclonal ZBTB7B antibody Background: ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment...
Mouse monoclonal ZMAT2 antibody Background: The function of this gene has not been determined.
Mouse monoclonal ZNF131 antibody Background: This gene may be involved in transcriptional regulation. It also plays a role during development and organogenesis as well as in the function of the...
Mouse monoclonal ZNF3 antibody Background: This gene is involved in cell differentiation and/or proliferation.
Mouse monoclonal ZNF313 antibody Background: This gene may play a role in spermatogenesis.
Mouse monoclonal ZNF410 antibody Background: This gene is a transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.
Mouse monoclonal ZNF75 antibody Background: This gene encodes a protein that likely functions as a transcription factor. The protein, which belongs to the ZNF75 family, includes an N-terminal SCAN domain,...
Mouse monoclonal ZNF83 antibody Background: This gene may be involved in transcriptional regulation.
Mouse monoclonal ZNF96 antibody Background: This gene may be involved in transcriptional regulation.
Mouse Mouse monoclonal IL2 antibody Background: Interleukin-2 is an interleukin which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between...
Rat monoclonal alpha 6 Integrin antibody Background: Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the ECM. They...
Rat monoclonal PSF1 antibody Background: PSF1 is one of the members of the GINS complex (other members being PSF2, PSF3 and SLD5) which is vital in the generation of replication...
Rat monoclonal SLD5 antibody Background: The GINS complex is composed of four subunits, encoded by SLD5, PSF1, PSF2, and PSF3. Genetic interactions between these four genes also suggest that they...

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