Rigaku Corporation Macromolecular X-Ray Crystallography System Phasing HomeLab

Anomalous scattering with soft X-ray radiation creates new possibilities in phasing for macromolecular crystallography. The heart of a Cr-Phasing HomeLab is any Rigaku rotating anode generator with a chromium anode. All Rigaku rotating anode generators can be equipped with chromium (Cr) targets to provide the foundation for a Cr-Phasing HomeLab. All Cr-Phasing HomeLabs use the same optics and choice of large aperture detector. VariMax™ Cr optics maximize the beam produced by the Rigaku generators and deliver it exactly where it is needed: on the crystal. Incident and exit helium beam paths reduce air absorption and reduce background scatter. Since Cr radiation expands the diffraction pattern relative to Cu, a large aperture detector, such as the Rigaku R-AXIS IV++ or R-AXIS HTC, is recommended. Investigators who wish to increase the throughput of de novo structure solution in their home laboratory. This would include investigators involved in the structural genomics initiative who wish to solve structures between synchrotron trips.