A.G. Scientific, Inc. Chk2 Inhibitor C-2264

Description
A cell-permeable, potent, and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC50 = 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC50 = 12 μM and 17 μM, respectively) and only weakly affects the activities of a panel of 31 kinases ( 25% inhibition at 10 μM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from î³-irradiation-induc ed apoptosis with an EC50 of 3 μM and 7.6 μM, respectively.
Description
A cell-permeable, potent, and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC50 = 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC50 = 12 μM and 17 μM, respectively) and only weakly affects the activities of a panel of 31 kinases ( 25% inhibition at 10 μM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from î³-irradiation-induc ed apoptosis with an EC50 of 3 μM and 7.6 μM, respectively.

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A.G. Scientific, Inc.
San Diego, CA, USA
Chk2 Inhibitor
C-2264
Chk2 Inhibitor C-2264
A cell-permeable, potent, and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC50 = 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC50 = 12 μM and 17 μM, respectively) and only weakly affects the activities of a panel of 31 kinases ( 25% inhibition at 10 μM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from î³-irradiation-induc ed apoptosis with an EC50 of 3 μM and 7.6 μM, respectively.

A cell-permeable, potent, and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC50 = 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC50 = 12 μM and 17 μM, respectively) and only weakly affects the activities of a panel of 31 kinases ( 25% inhibition at 10 μM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 μM and 7.6 μM, respectively.

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Technical Specifications

  A.G. Scientific, Inc.
Product Category Biological Materials
Product Number C-2264
Product Name Chk2 Inhibitor
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