Anti-PTH antibody is useful to distinguish parathyroid hyperplasia/neoplasm
s from thyroid and metastatic neoplasms; although the pathologist is typically aware of the preoperative hypercalcemic status. Occasionally when the surgeon does not supply this information PTH immunohistochemistry is essential. Even more problematic, are situations in which clear cell parathyroid carcinomas are nonsecretory without an abnormality in mineral metabolism
Anti-PTH antibody is useful to distinguish parathyroid hyperplasia/neoplasms from thyroid and metastatic neoplasms; although the pathologist is typically aware of the preoperative hypercalcemic status. Occasionally when the surgeon does not supply this information PTH immunohistochemistry is essential. Even more problematic, are situations in which clear cell parathyroid carcinomas are nonsecretory without an abnormality in mineral metabolism
