Ventana Medical Systems, Inc. CONFIRM Desmin 760-2513

CONFIRM anti-Desmin (DE-R-11) identifies normal muscle cells and myogenic neoplasms bearing the desmin antigen. The most obvious application of anti-desmin antibodies is in the characterization of myogenic neoplasms or in the recognition of myogenic cell lines in mixed sarcomas. Among neoplasms, carcinomas do not react with anti-desmin antibodies, leiomyosarcomas, and rhabdomyosarcomas are positive, and other sarcomas (with some exceptions) are negative. Myogenic sarcomas can be classified as such, due to their positive staining with antibodies to muscle (specific) actin and desmin. Because of the different sensitivities and specificities of these antibodies, they are best used in combination.