CD2 is one of the earliest T cell lineage restricted antigens to appear during T cell differentiation and only a rare CD2+ cell can be found in the bone marrow. It is found in all T-lymphocytes and natural killer cells but not in B cells or any other cell population.
CD2 can be considered a pan-T cell antigen and is therefore useful for the identification of virtually all normal T lymphocytes. It is also very useful in the assessment of lymphoid malignancies as it is expressed in the majority of precursor and post-thymic lymphomas and leukemias and is not expressed by B neoplasms (Foon & Todd, 1986). As with other pan-T cell antigens, CD2 may be aberrantly deleted in some neoplastic T cell population, especially peripheral T cell lymphomas. Rarely slg+ B cell neoplasms have been described to form spontaneous E-rosettes but these reactions are not mediated via the CD2 receptor (Knowles, 1989).
| Ventana Medical Systems, Inc. | |
|---|---|
| Product Category | Organic Chemicals |
| Product Number | 760-4377 |
| Product Name | CD2 |
