Ventana Medical Systems, Inc. p53 760-2542

Anti-p53 (Bp53-11) is directed against both the mutant and wild type of the p53 nuclear phosphoprotein. Very rare normal cells express p53, but alterations in the p53 suppressor gene result in an overproduction of this protein in malignancies. This reagent may be used to aid in the identification of abnormally proliferating cells in neoplastic cell populations. Anti-p53 (Bp53-11) specifically binds to nuclear antigen(s) associated with the normal down regulation of cell division. Increased expression of p53 in actively dividing cells is an indication of loss of function due to mutation of the p53 gene.