Ventana Medical Systems, Inc. CONFIRM CD15 760-2504

Antibodies against CD15 normally react in a strong cell surface membrane staining pattern with granulocytes and granulocyte precursors, monocytes, a subset of tissue macrophages, and activated T lymphocytes. CONFIRM anti-CD15 (MMA) also reacts against the Reed-Sternberg cells of Hodgkin's disease and, because it recognizes a carbohydrate antigen, is also expressed by a variety of carcinoma types but is negative in malignant mesotheliomas. Antibodies against CD15 are used diagnostically to (1) support a diagnosis of acute myeloid leukemia, (2) help support a diagnosis of Hodgkin'sdisease, and (3) help separate poorly differentiated adenocarcinomas from malignant mesothelioma.