Alpha Diagnostic International, Inc. Anti-rat/Human GABAa Receptor Gamma 2 (GAG2) IgG #1, aff. Pure GAG21-A

Anti-rat/Human GABAa Receptor Gamma 2 (GAG2) IgG #1, aff. Pure General Information GABA A (GAA) receptor proteins (450-627 aa) are characterized by the presence of a cleavable signal peptide, a large extracellular N-terminus, 3 TM (transmembrane) domains, a large cytoplasmic domain followed by TM4 and C-terminal extracellular domain. T SugApplications Most Antibodies are tested by ELISA and Western. Additional applications, such as IHC or IP may have been tested and will be listed in the product data sheets or published research papers using our products. Typically, antibodies are tested against the SugSecAntibodies http://4adi.com/comm erce/ccc2480-seconda ry-antibodies-rabbit .htm SpeciesReactivity Rat SugNegativeControl Non-immune Rabbit IgG Cat# 20009-1 Form Affinity purified IgG SugPositiveControl Recombinant or naturally purified proteins or cells of tissues expressing the protein under study can be used as positive controls for Western or IHC. Please review the ?General Information? tan under Product overview section. Control or blocking peptid Antigen 30-aa peptide from rat GAG2 (1); Designation (GAG21-P, control/blocking peptide); epitope location ~ N-terminus, Extracellular domain SpCrossreactivity The 30 AA rat GAG21-P control peptide is 100% conserved in bovine, human, and mouse GAG2. It is ~80% conserved in chicken GAB2. Significant homology of GAG21-P is also seen with rat GAG1 (64%), rat GAG3 (55%). It is not clear if anti-GAG21 actually react with other gamma subunits. However, no significant homology of GAG21-P is observed with other GAA subunits (alpha, beta etc.). Antibody cross-reactivity of anti-GAG21 in various species has also not been studied. For research use only, not for diagnostic or therapeutic use.