Alpha Diagnostic International, Inc. Human Amyloid precursor protein (APP770) Control/blocking peptide APP11-P

Human Amyloid precursor protein (APP770) Control/blocking peptide General Information APP gene has 19 exons (1). At least 8 different types of APP (APP695, APP751, and APP770 are the major ones) are produced as a result of alternative splicing of exons 7, 8, and 15. Exons 7 codes for a 57-aa domain that is analogous to Kunitz protease in SugApplications Control or blocking peptides are recommended for ELISA plate coating for direct ELISA testing of antibodies or competitive ELISA, and antibody blocking or neutralization. SpeciesReactivity Human Form Antigen/blocking Peptide Antigen 15aa peptide of Human APP770 ; Designated (APP11-P or control peptide). Epitope location ~ Mid-region, Extracellular SpCrossreactivity The human APP11-P peptide sequence is only found in APP that contains the KPI region (i.e., APP770 isoform). The APP11-P sequence is the same in mouse and rat APP770 isoforms. Antibody crossreactivity in various species is not established For research use only, not for diagnostic or therapeutic use.