Ventana Medical Systems, Inc. CONFIRM Tyrosinase 790-4365

Tyrosinase is an enzyme involved in the production of melanin pigments. This enzyme catalyzes the formation of melanin within the cells and thus becomes a useful marker for the presence of melanocytes and melanosomes. As a marker of melanocytic lineage, tyrosinase is localized to melanocytes which can be found on the dermal/epidermal junction of normal skin, but is not detected in other normal cells. Expression of tyrosinase is also found in melanocytic lesions including benign nevi and the majority of primary and metastatic malignant melanomas, and not in non-melanocytic tumor types.