CONFIRM anti-EGFR (5B7) is a rabbit monoclonal antibody produced against a synthetic peptide from the carboxy terminal (cytoplasmic) region of EGFR. The epitope recognized by anti-EGFR (5B7) is associated with an internal domain of EGFR, and therefore EGFR staining with antibodies that recognize extracellular domains may not always correlate with CONFIRM anti-EGFR (5B7) staining. EGFR is a member of the receptor tyrosine kinase HER family. Also known as HER 1, EGFR is structurally related to HER 2, HER 3, and HER 4. Members of this protein family are capable of forming heterodimers to mediate signal transduction. EGFR is expressed at low levels in most normal epithelial tissues, but can be overexpressed in cancers of the breast, brain, bladder, lung, gastric, head and neck, esophagus, cervix, ovary, endometrium, and particularly in squamous cell carcinomas.
| Ventana Medical Systems, Inc. | |
|---|---|
| Product Category | Organic Chemicals |
| Product Number | 790-4347 |
| Product Name | CONFIRM EGFR (Epidermal Growth Factor Receptor) |
