Protein gene product 9.5 (PGP 9.5), also known as ubiquitin carboxyl terminal hydrolase-1(UCH-L1), is a 27-kD protein originally isolated from whole brain extracts (1). Although PGP 9.5 expression in normal tissues was originally felt to be strictly confined to neurons and neuroendocrine cells (2), it has been subsequently documented in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells,and dermal fibroblasts. LK Campbell et al. demonstrated immunostaining of a plethora of different mesenchymal neoplasms with this antibody.
Protein gene product 9.5 (PGP 9.5), also known as ubiquitin carboxyl terminal hydrolase-1(UCH-L1), is a 27-kD protein originally isolated from whole brain extracts (1). Although PGP 9.5 expression in normal tissues was originally felt to be strictly confined to neurons and neuroendocrine cells (2), it has been subsequently documented in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells,and dermal fibroblasts. LK Campbell et al. demonstrated immunostaining of a plethora of different mesenchymal neoplasms with this antibody.
