Ventana Medical Systems, Inc. CD45 (LCA) 760-4279

Anti-Leukocyte Common Antigen (Anti-LCA) monoclonal antibody is routinely used to aid in the differential diagnosis of undifferentiated neoplasms, whenever malignant lymphomais suspected by the morphological or clinical data. It is a highly specific antibody therefore a positive result is highly indicative of lymphoid or myeloid origin. Certain types of lymphoid neoplasms may lack CD45 (Hodgkin's disease, some T-cell lymphomas and some leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is expressed almost exclusively by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes, erythrocytes, and plasma cell precursors.