Ventana Medical Systems, Inc. bcl-6 760-4241

Anti-bcl-6 is a transcriptional regulator gene which codes for a 706-amino acid nuclear zinc finger protein. Antibodies to this protein stain the germinal center cells in lymphoidfollicles, the follicular and interfolliculr cells in follicular lymphoma, diffuse large B-celllymphomas and Burkitt's lymphoma, and the majority of the Reed-Sternberg cells innodular lymphocyte predominant Hodgkin's Disease. In contrast, anti-bcl-6 rarely stains mantle cell lymphoma and MALT lymphoma. bcl-6 expression is seen in approximately 45% of CD30+ anaplastic large cell lymphomas but is consistently absent in other peripheral T-cell lymphomas.