Ventana Medical Systems, Inc. CONFIRM S100 760-2523

S100 was first detected in nervous tissue and has subsequently been found in a number of other cell types including glial and neural cells, Schwann cells, melanocytes and nevus cells, cells of cartilaginous and fatty tissue, myoepithelial cells, and also Langerhans cells. S100 is a sensitive marker for melanoma. Antibodies against S100 stain amelanotic melanomas more strongly than pigmented tumors and detect melanomas that are often negative for other melanocytic markers, such as desmoplastic melanomas. Although S100 is highly sensitive for melanomas, many non melanocytic tumors also show S100 positivity. S100 typically is present in neural cells (glial cells and Schwann cells) and their corresponding tumors.