An inhibitor of the bcr-abl tyrosine kinase. It acts by binding to the ATP binding site of bcr-abl. Imatinib also stimulates the entry of the bcr-abl tyrosine kinase into the nucleus, where it cannot perform its anti-apoptopic functions.
It inhibits EOL-1 cell viability (IC50 = 0.5 nM), phosphorylation of a fusion protein (IC50 = 30 nM), and viability of BaF3 cells expressing Rhe-PDGFRα in the absence of IL-3 (IC50 = 0.17 nM).
| A.G. Scientific, Inc. | |
|---|---|
| Product Category | Biological Materials |
| Product Number | I-2359 |
| Product Name | Imatinib Mesylate (CGP-57148B, STI-571) |
