Cell-permeable. An antioxidant and dual inhibitor of 5-lipoxygenase (IC50 = 8 μM) and cyclooxygenase (COX) (IC50 = 52 μM). Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Also shown to be a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, inhibiting the acetylation of histones H3 and H4 with an IC50 of ~25 μM. Does not affect p300/CREB binding protein-associated factor (PCAF).
| A.G. Scientific, Inc. | |
|---|---|
| Product Category | Biological Materials |
| Product Number | C-2275 |
| Product Name | Curcumin, Curcuma longa (High Purity) |
