ABT-869 is multi-targeted inhibitor of all members of the VEGF and PDGF receptor families (e.g., KDR, IC50 value of 4 nM), but has much less activity (IC50 values >1 μM) against unrelated receptor tyrosine kinases, soluble tyrosine kinases or serine/threonine kinases. The kinase inhibition profile of ABT-869 is evident in cellular assays of RTK phosphorylation (IC50 values of 2, 4 and 7 nM for PDGFRβ, KDR and CSF-1R, respectively) and VEGF-stimulated proliferation (0.2 nM IC50 for human endothelial cells).
| A.G. Scientific, Inc. | |
|---|---|
| Product Category | Biological Materials |
| Product Number | A-2177 |
| Product Name | ABT-869 |
