A semi-synthetic derivate of Geldanamcyin, 17-DMAG binds to Hsp90 and alters its function. A water soluble & cell-permeable analog of Geldanamycin (G-1047) and 17-AAG (A-1256), 17-DMAG binds to the APTase site of human Hsp90a with high affinity, has cytotoxic activity against many cancer cell lines, and acts as angiogenesis inhibitor. Treatment with 17-DMAG significantly reduced the hemorrhage-induced increases in iNOS protein, jejunal alteration, and IL-10 concentrations, but 17-DMAG did not affect the hemorrhage-induced increases in p53 and IL-6 concentration.1 17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-? increase, and caspase-3 activation. JG Kiang, NG Agravante, et al, January 1, 2011; 1(1): 21. We examined the optimal conditions for combination of radiation with the newly developed HSP90inhibitor, 17-(dimethylaminoeth
ylamino)-17-demethox
ygeldanamycin(DMAG) to increase the radiosensitivity of tumor cells in vitro.2 HSP90 inhibitor, 17-DMAG, enhances radiosensitivity of human cancer cells. Thuy Tran, Steven Feis, et al, Apr 2006; 2006: 1034.
A semi-synthetic derivate of Geldanamcyin, 17-DMAG binds to Hsp90 and alters its function. A water soluble & cell-permeable analog of Geldanamycin (G-1047) and 17-AAG (A-1256), 17-DMAG binds to the APTase site of human Hsp90a with high affinity, has cytotoxic activity against many cancer cell lines, and acts as angiogenesis inhibitor.
Treatment with 17-DMAG significantly reduced the hemorrhage-induced increases in iNOS protein, jejunal alteration, and IL-10 concentrations, but 17-DMAG did not affect the hemorrhage-induced increases in p53 and IL-6 concentration.1 17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-? increase, and caspase-3 activation. JG Kiang, NG Agravante, et al, January 1, 2011; 1(1): 21.
We examined the optimal conditions for combination of radiation with the newly developed HSP90inhibitor, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin(DMAG) to increase the radiosensitivity of tumor cells in vitro.2 HSP90 inhibitor, 17-DMAG, enhances radiosensitivity of human cancer cells. Thuy Tran, Steven Feis, et al, Apr 2006; 2006: 1034.
