A.G. Scientific, Inc. 17-AAG A-1256

Description
17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90). Hsp90 is a protein chaperone that binds to signaling proteins, known as "client proteins." These client proteins include key cancer-relevant targets such as mutated p53, Bcr-Abl, Her2, Akt, Raf-1, B-Raf, and others. 17-AAG is able to disrupt the Hsp90-client protein complexes and lead to the degradation of the client proteins. Seeking published researchers utilizing our 17-AAG product? Hit the hot link for the full paper. 1. http://clincancerres .aacrjournals.org/co ntent/14/3/847.full. pdf+html 2. http://jcb.rupress.o rg/content/178/2/283 .full.pdf+html 3. http://hmg.oxfordjou rnals.org/content/19 /22/4421.full.pdf+ht ml 4. http://cancerres.aac rjournals.org/conten t/67/10/4989.full.pd f+html 5. http://www.jbc.org/c ontent/284/8/4921.fu ll.pdf+html 6. http://mcb.asm.org/c ontent/27/5/1809.ful l.pdf+html 7. http://cancerres.aac rjournals.org/conten t/65/24/11658.full.p df+html 8. http://www.pnas.org/ content/105/9/3622.f ull.pdf+html 9. http://cancerres.aac rjournals.org/conten t/67/8/3777.full.pdf +html 10. http://cancerres.aac rjournals.org/conten t/67/18/8716.full.pd f+html 11. http://www.jneurosci .org/content/29/39/1 2079.full.pdf+html 12. www.pnas.org/content /107/28/12634.full.p df+html 13. http://bloodjournal. hematologylibrary.or g/content/116/18/358 2.full.pdf+html 14. http://www.jbc.org/c ontent/285/16/11966. full.pdf+html 15. http://jnm.snmjourna ls.org/content/51/2/ 183.full.pdf+html 16. http://www.jbc.org/c ontent/284/38/25889. full.pdf+html 'LIKE US' ON FACEBOOK AND RECEIVE 10% OFF YOUR ENTIRE ORDER. CLICK BLUE ARROW. Seeking published researchers utilizing our 17-AAG product? Hit the hot link for the full paper. 1. Regulated Binding of Importin-α to Protein Kinase C in Response to Apoptotic Signals Facilitates Nuclear Import, Tariq S. Adwan, Angela M. Ohm, et al, Oct 2011; 286: 35716 - 35724. 2. The Dual EGFR/HER2 Inhibitor Lapatinib Synergistically Enhances the Antitumor Activity of the Histone Deacetylase Inhibitor Panobinostat in Colorectal Cancer Models, Melissa J. LaBonte, Peter M. Wilson, et al, May 2011; 71: 3635 - 3648. 3. Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90), Lawrence C.S. Tam, Anna-Sophia Kiang, et al, Nov 2010; 19: 4421 - 4436. 4. Bag1 directly routes immature BCR-ABL for proteasomal degradation, Fujiko Tsukahara and Yoshiro Maru Blood,Nov 2010; 116: 3582 - 3592. 5. Hsp90 Directly Modulates the Spatial Distribution of AF9/MLLT3 and Affects Target Gene Expression, Jeffrey J. Lin and Charles S. Hemenway, Apr 2010; 285: 11966 - 11973. 6. Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability, Umesh K. Jinwal, Yoshinari Miyata, et al, Sep 2009; 29: 12079 - 12088.
Description
17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90). Hsp90 is a protein chaperone that binds to signaling proteins, known as "client proteins." These client proteins include key cancer-relevant targets such as mutated p53, Bcr-Abl, Her2, Akt, Raf-1, B-Raf, and others. 17-AAG is able to disrupt the Hsp90-client protein complexes and lead to the degradation of the client proteins. Seeking published researchers utilizing our 17-AAG product? Hit the hot link for the full paper. 1. http://clincancerres .aacrjournals.org/co ntent/14/3/847.full. pdf+html 2. http://jcb.rupress.o rg/content/178/2/283 .full.pdf+html 3. http://hmg.oxfordjou rnals.org/content/19 /22/4421.full.pdf+ht ml 4. http://cancerres.aac rjournals.org/conten t/67/10/4989.full.pd f+html 5. http://www.jbc.org/c ontent/284/8/4921.fu ll.pdf+html 6. http://mcb.asm.org/c ontent/27/5/1809.ful l.pdf+html 7. http://cancerres.aac rjournals.org/conten t/65/24/11658.full.p df+html 8. http://www.pnas.org/ content/105/9/3622.f ull.pdf+html 9. http://cancerres.aac rjournals.org/conten t/67/8/3777.full.pdf +html 10. http://cancerres.aac rjournals.org/conten t/67/18/8716.full.pd f+html 11. http://www.jneurosci .org/content/29/39/1 2079.full.pdf+html 12. www.pnas.org/content /107/28/12634.full.p df+html 13. http://bloodjournal. hematologylibrary.or g/content/116/18/358 2.full.pdf+html 14. http://www.jbc.org/c ontent/285/16/11966. full.pdf+html 15. http://jnm.snmjourna ls.org/content/51/2/ 183.full.pdf+html 16. http://www.jbc.org/c ontent/284/38/25889. full.pdf+html 'LIKE US' ON FACEBOOK AND RECEIVE 10% OFF YOUR ENTIRE ORDER. CLICK BLUE ARROW. Seeking published researchers utilizing our 17-AAG product? Hit the hot link for the full paper. 1. Regulated Binding of Importin-α to Protein Kinase C in Response to Apoptotic Signals Facilitates Nuclear Import, Tariq S. Adwan, Angela M. Ohm, et al, Oct 2011; 286: 35716 - 35724. 2. The Dual EGFR/HER2 Inhibitor Lapatinib Synergistically Enhances the Antitumor Activity of the Histone Deacetylase Inhibitor Panobinostat in Colorectal Cancer Models, Melissa J. LaBonte, Peter M. Wilson, et al, May 2011; 71: 3635 - 3648. 3. Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90), Lawrence C.S. Tam, Anna-Sophia Kiang, et al, Nov 2010; 19: 4421 - 4436. 4. Bag1 directly routes immature BCR-ABL for proteasomal degradation, Fujiko Tsukahara and Yoshiro Maru Blood,Nov 2010; 116: 3582 - 3592. 5. Hsp90 Directly Modulates the Spatial Distribution of AF9/MLLT3 and Affects Target Gene Expression, Jeffrey J. Lin and Charles S. Hemenway, Apr 2010; 285: 11966 - 11973. 6. Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability, Umesh K. Jinwal, Yoshinari Miyata, et al, Sep 2009; 29: 12079 - 12088.

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Company
Product
Description
Supplier Links
A.G. Scientific, Inc.
San Diego, CA, USA
17-AAG
A-1256
17-AAG A-1256
17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90). Hsp90 is a protein chaperone that binds to signaling proteins, known as "client proteins." These client proteins include key cancer-relevant targets such as mutated p53, Bcr-Abl, Her2, Akt, Raf-1, B-Raf, and others. 17-AAG is able to disrupt the Hsp90-client protein complexes and lead to the degradation of the client proteins. Seeking published researchers utilizing our 17-AAG product? Hit the hot link for the full paper. 1. http://clincancerres .aacrjournals.org/co ntent/14/3/847.full. pdf+html 2. http://jcb.rupress.o rg/content/178/2/283 .full.pdf+html 3. http://hmg.oxfordjou rnals.org/content/19 /22/4421.full.pdf+ht ml 4. http://cancerres.aac rjournals.org/conten t/67/10/4989.full.pd f+html 5. http://www.jbc.org/c ontent/284/8/4921.fu ll.pdf+html 6. http://mcb.asm.org/c ontent/27/5/1809.ful l.pdf+html 7. http://cancerres.aac rjournals.org/conten t/65/24/11658.full.p df+html 8. http://www.pnas.org/ content/105/9/3622.f ull.pdf+html 9. http://cancerres.aac rjournals.org/conten t/67/8/3777.full.pdf +html 10. http://cancerres.aac rjournals.org/conten t/67/18/8716.full.pd f+html 11. http://www.jneurosci .org/content/29/39/1 2079.full.pdf+html 12. www.pnas.org/content /107/28/12634.full.p df+html 13. http://bloodjournal. hematologylibrary.or g/content/116/18/358 2.full.pdf+html 14. http://www.jbc.org/c ontent/285/16/11966. full.pdf+html 15. http://jnm.snmjourna ls.org/content/51/2/ 183.full.pdf+html 16. http://www.jbc.org/c ontent/284/38/25889. full.pdf+html 'LIKE US' ON FACEBOOK AND RECEIVE 10% OFF YOUR ENTIRE ORDER. CLICK BLUE ARROW. Seeking published researchers utilizing our 17-AAG product? Hit the hot link for the full paper. 1. Regulated Binding of Importin-α to Protein Kinase C in Response to Apoptotic Signals Facilitates Nuclear Import, Tariq S. Adwan, Angela M. Ohm, et al, Oct 2011; 286: 35716 - 35724. 2. The Dual EGFR/HER2 Inhibitor Lapatinib Synergistically Enhances the Antitumor Activity of the Histone Deacetylase Inhibitor Panobinostat in Colorectal Cancer Models, Melissa J. LaBonte, Peter M. Wilson, et al, May 2011; 71: 3635 - 3648. 3. Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90), Lawrence C.S. Tam, Anna-Sophia Kiang, et al, Nov 2010; 19: 4421 - 4436. 4. Bag1 directly routes immature BCR-ABL for proteasomal degradation, Fujiko Tsukahara and Yoshiro Maru Blood,Nov 2010; 116: 3582 - 3592. 5. Hsp90 Directly Modulates the Spatial Distribution of AF9/MLLT3 and Affects Target Gene Expression, Jeffrey J. Lin and Charles S. Hemenway, Apr 2010; 285: 11966 - 11973. 6. Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability, Umesh K. Jinwal, Yoshinari Miyata, et al, Sep 2009; 29: 12079 - 12088.

17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90).
Hsp90 is a protein chaperone that binds to signaling proteins, known as "client proteins." These client proteins include key cancer-relevant targets such as mutated p53, Bcr-Abl, Her2, Akt, Raf-1, B-Raf, and others.
17-AAG is able to disrupt the Hsp90-client protein complexes and lead to the degradation of the client proteins.
Seeking published researchers utilizing our 17-AAG product? Hit the hot link for the full paper.
1. http://clincancerres.aacrjournals.org/content/14/3/847.full.pdf+html
2. http://jcb.rupress.org/content/178/2/283.full.pdf+html
3. http://hmg.oxfordjournals.org/content/19/22/4421.full.pdf+html
4. http://cancerres.aacrjournals.org/content/67/10/4989.full.pdf+html
5. http://www.jbc.org/content/284/8/4921.full.pdf+html
6. http://mcb.asm.org/content/27/5/1809.full.pdf+html
7. http://cancerres.aacrjournals.org/content/65/24/11658.full.pdf+html
8. http://www.pnas.org/content/105/9/3622.full.pdf+html
9. http://cancerres.aacrjournals.org/content/67/8/3777.full.pdf+html
10. http://cancerres.aacrjournals.org/content/67/18/8716.full.pdf+html
11. http://www.jneurosci.org/content/29/39/12079.full.pdf+html
12. www.pnas.org/content/107/28/12634.full.pdf+html
13. http://bloodjournal.hematologylibrary.org/content/116/18/3582.full.pdf+html
14. http://www.jbc.org/content/285/16/11966.full.pdf+html
15. http://jnm.snmjournals.org/content/51/2/183.full.pdf+html
16. http://www.jbc.org/content/284/38/25889.full.pdf+html
'LIKE US' ON FACEBOOK AND RECEIVE 10% OFF YOUR ENTIRE ORDER. CLICK BLUE ARROW.
Seeking published researchers utilizing our 17-AAG product? Hit the hot link for the full paper.
1. Regulated Binding of Importin-α to Protein Kinase C in Response to Apoptotic Signals Facilitates Nuclear Import, Tariq S. Adwan, Angela M. Ohm, et al, Oct 2011; 286: 35716 - 35724.
2. The Dual EGFR/HER2 Inhibitor Lapatinib Synergistically Enhances the Antitumor Activity of the Histone Deacetylase Inhibitor Panobinostat in Colorectal Cancer Models, Melissa J. LaBonte, Peter M. Wilson, et al, May 2011; 71: 3635 - 3648.
3. Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90), Lawrence C.S. Tam, Anna-Sophia Kiang, et al, Nov 2010; 19: 4421 - 4436.
4. Bag1 directly routes immature BCR-ABL for proteasomal degradation, Fujiko Tsukahara and Yoshiro Maru
Blood,Nov 2010; 116: 3582 - 3592.
5. Hsp90 Directly Modulates the Spatial Distribution of AF9/MLLT3 and Affects Target Gene Expression, Jeffrey J. Lin and Charles S. Hemenway, Apr 2010; 285: 11966 - 11973.
6. Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability, Umesh K. Jinwal, Yoshinari Miyata, et al, Sep 2009; 29: 12079 - 12088.

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Technical Specifications

  A.G. Scientific, Inc.
Product Category Biological Materials
Product Number A-1256
Product Name 17-AAG
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