Sartorius Lab Instruments GmbH & Co. KG Hydrosart® Ultrafiltration Sartocon® Slice Cassette Filters 3M5 144 39 01 E--SW

Hydrosart® Membranes are stabilized cellulose based membranes that have been optimized for the biotechnological and pharmaceutical industry. The Hydrosart® membrane is a stable polymer that features a broad pH range. Hydrosart is also extremely hydrophilic, making it non-protein binding, virtually non-foul and has extremely high flux. Membrane regeneration, storage and depyrogenation can be accomplished by using NaOH even at elevated temperatures. These features make Hydrosart® an ideal membrane for biological applications. Hydrosart® ultrafiltration cassettes are available in the following nominal molecular weight cutoffs: 2 kD|5 kD|10 kD|30 kD|100kD Applications: Hydrosart® ultrafiltration membranes are designed for use in the biotechnological and pharmaceutical industries. They can be used for the following applications: Oligonucleotide, proteins (albumin - even with 40% EtOH - , hemoglobin), coagulation factors (factor VIII, factor III), vaccines (tetanus, diphteria), monoclonal antibodies. Product profile: Hydrosart® shows minimal adsorption of proteins, viruses, etc. Membrane retention is unaffected by repeated use. The Hydrosart® ultrafiltration membrane can be re-used without any loss of integrity or performance. Hydrosart® ultrafiltration cassettes have been validated to withstand in-line steam sterilization without any loss or changes in membrane retention. The Hydrosart® high performance membrane is a stabilized cellulose based membrane that has been optimized for the biotechnological and pharmaceutical industry. The Hydrosart® membrane is a stable polymer that features the capability of operating in a broad pH range. Hydrosart® is also extremely hydrophilic, making it non-protein binding and generally non-fouling. Hydrosart® exhibits extremely high flux under extreme protein loads. Membrane cleaning, storage and depyrogenation can be accomplished by using NaOH even at elevated temperatures and concentrations. These features make Hydrosart® an ideal membrane for biological applications. Sartocon® ECO ultrafiltration cassettes are available in the following nominal molecular weight cutoffs: 10 kD| 30 kD|100 kD Regulatory Compliance: All materials have passed the current USP Biological Test. The filtrate meets or exceeds USP and EP requirements for Sterile Water for Injection with respect to total solids, oxidizable substances, particulate matter, ammonia, chloride, nitrate, sulfate and heavy metals. Quality control: Each filter cassette is individually assigned a serial number, integrity tested and certified. It complies with cGMP requirements for non-fiber-releasing filters and is filed under the Drug Master File Number DMF 5967 by the Food and Drug Administration, Washington, DC. Validation information is available upon request. Regulatory Compliance: All materials have passed the USP Biological Test and the in Vivo Biological reactivity test according to USP Plastic Class Test VI. The filtrate meets or exceeds the currently valid USP and EP for sterile Water for Injection, with respect to bacteria endotoxins, particulate matter, oxidizable substances, pH dependent conductivity, extractable substances such as ammonia, chloride, sulfate, calcium and nitrate. Low feed flow requirements (low cross flow flux) for the benefit of low pump energy consumption Thin channel design in support of high mass transfers at low feed flow rates Competable with competitive pump capacity in support of excellent performance in all crossflow systems