Waters Corporation ACQUITY UPLC System

UPLC transforms the expectations of laboratories worldwide UPLC Technology, which has been adopted successfully in laboratories around the world for the most demanding separations, is highly robust, dependable, and reproducible. Work at higher efficiencies with a much wider range of linear velocities, flow rates, and backpressures Higher flow rates and increased throughput result in superior resolution and sensitivity Eliminate significant time and cost per sample, while improving quality of results Benefit from Waters’ patented sub-2-μm hybrid particle chemistry Features of the ACQUITY UPLC System Comprehensive system components, including the ACQUITY UPLC Sample Organizer, Column Manager and Heater/Cooler, Binary Solvent Manager and Sample Manager, for customized throughput and condition requirements Easy HPLC to UPLC method conversion with the ACQUITY UPLC console calculator Support for existing HPLC methods Predictive system support with Connections INSIGHT® remote intelligent services Chemistries and formats to suit specific analytical tasks, including ACQUITY UPLC 1.7 μm columns, VanGuard pre-columns or ACQUITY UPLC HSS and HSS T3 1.8 μm columns Extended detection capabilities with ACQUITY UPLC Fluorescence (FLR), Tunable UV (TUV), Photodiode Array (PDA), Evaporative Light Scattering (ELS), and Refractive Index (RI) detectors to single, tandem, and time-of-flight mass spectrometers Easily compatible with third-party MS solutions (ABI/MDS SCIEX, Bruker Daltonics, and Thermo Fisher Scientific) ACQUITY UPLC System Advantages Efficiency gains with sub-2 μm particles: Provides 3X higher efficiency than 5 μm particles 70% higher resolution than 5 μm particles For gradient separations, peak capacity is used to measure the resolving power Better information gained when analyzing more samples per unit time: Column length can be reduced by a factor of three with methods transitioned from 5 μm particles to sub-2 μm particles, with the same efficiency Separations can be run at a 3X higher flow rate Generate a 9X increase in throughput with no loss in resolution Detect compounds at increasingly lower levels without inherent changes to the detection mode, either optical or MS: The ACQUITY UPLC System with sub-2 μm particles provides up to 70% higher sensitivity In the case of equal efficiency but faster analysis times, the equivalent is 3X higher sensitivity than 5 μm particles Beyond optical detection and looking at MS, the less dispersed peaks with higher concentration effectively yield improved ionization efficiency, making ACQUITY UPLC the ideal inlet for any MS detector