Oro-Sep Cartridges are molded from medical grade virgin polypropylene, fritted with 20 micron PE frits and are compatible with a syringe or a vacuum manifold. The female luer tip inlet of the cartridge allows connection to a syringe tip. The male luer tip outlet connects to a vacuum manifold. Sep-Pak®cartridges may be substituted with Oro-Sep cartridges. Oro-Sep cartridges packed with reversed phases, normal phases, and ion exchange phases in three different bed sizes, may be utilized for sample preparation and sample concentration in the bio-tech, clinical, environmental, forensic, and pharmaceutical arena.