Description
Additional Properties
Hydrolytic Sensitivity 4: no reaction with water under neutral conditions Application Review of synthetic utility.1 Serves as an alcohol equivalent in reaction with aryl iodides.2 Can provide protection for the anomeric center of carbohydrates.3 Fieser F&F: Vol. 8, p 510. Reference 1. Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis, Fuchs, P. L. Ed., John Wiley and Sons, Ltd., 2011, p. 622-627. 2. Dibakar, M. et al. Tetrahedron Lett. 2011, 41, 5338. 3. Sowell, C. G. et al. Tetrahedron Lett. 1996, 37, 609. Safety
Packaging Under Nitrogen Specialty Silicon-Based Blocking Agent Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure. Trimethylsilylethano
l; 2-Hydroxyethyltrimet
hylsilane
Used for protection of acids
Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure
