Gelest, Inc. TRIETHYLCHLOROSILANE SIT8250.0

Additional Properties Hydrolytic Sensitivity 8: reacts rapidly with moisture, water, protic solvents Application Forms silylated derivatives of alcohols stable to Grignard conditions.1 Reference 1. Arkles, B. In Handbook of Grignard Reagents; Silverman, G., Ed; Marcel Dekker: 1996; p667. Safety Packaging Under Nitrogen Trialkylsilyl Blocking Agent Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure. Triethylchlorosilane ; Chlorotriethylsilane ; TES-Cl Stability of ethers intermediate between TMS and TBS ethers Good for 1°, 2°, 3° alcohols Can be cleaved in presence of TBS, TIPS and TBDPS ethers Used primarily for the protection of alcohols Can be used to protect amines and carboxylic acids Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure