Additional Properties
Hydrolytic Sensitivity 4: no reaction with water under neutral conditions Application Reacts with enol silyl ethers to form ?,?-bis-trans-?-trie
thylsilylethenyl ketones.1 Useful in Sonogashira cross-coupling reactions w/ more stable silyl group than the trimethylsilyl group.2 Reference 1. Amemiya, R. et al. Tetrahedron Lett. 2006, 47, 1797. 2. Larson, G. L. “Silicon-Based Cross-Coupling Reagents” Gelest, Inc. 2011. Safety
Packaging Under Nitrogen Alkynylsilane Cross-Coupling Agent The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile. Ethynyltriethylsilan
e; Triethylsilylacetyle
ne
More stable protected acetylene useful in Sonogashira reactions.
Reacts with enol silyl ethers to form ?,?-bis-trans-&beta-
triethylsilylethenyl ketones
Extensive review of silicon based cross-coupling agents: Denmark, S. E. et al. "Organic Reactions, Volume 75" Denmark, S. E. ed., John Wiley and Sons, 233, 2011
Gelest, Inc.
Done
Datasheet
Description
Additional Properties
Hydrolytic Sensitivity 4: no reaction with water under neutral conditions Application Reacts with enol silyl ethers to form ?,?-bis-trans-?-trie
thylsilylethenyl ketones.1 Useful in Sonogashira cross-coupling reactions w/ more stable silyl group than the trimethylsilyl group.2 Reference 1. Amemiya, R. et al. Tetrahedron Lett. 2006, 47, 1797. 2. Larson, G. L. “Silicon-Based Cross-Coupling Reagents” Gelest, Inc. 2011. Safety
Packaging Under Nitrogen Alkynylsilane Cross-Coupling Agent The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile. Ethynyltriethylsilan
e; Triethylsilylacetyle
ne
More stable protected acetylene useful in Sonogashira reactions.
Reacts with enol silyl ethers to form ?,?-bis-trans-&beta-
triethylsilylethenyl ketones
Extensive review of silicon based cross-coupling agents: Denmark, S. E. et al. "Organic Reactions, Volume 75" Denmark, S. E. ed., John Wiley and Sons, 233, 2011
Additional Properties
Hydrolytic Sensitivity 4: no reaction with water under neutral conditions Application Reacts with enol silyl ethers to form ?,?-bis-trans-?-trie
thylsilylethenyl ketones.1 Useful in Sonogashira cross-coupling reactions w/ more stable silyl group than the trimethylsilyl group.2 Reference 1. Amemiya, R. et al. Tetrahedron Lett. 2006, 47, 1797. 2. Larson, G. L. “Silicon-Based Cross-Coupling Reagents” Gelest, Inc. 2011. Safety
Packaging Under Nitrogen Alkynylsilane Cross-Coupling Agent The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile. Ethynyltriethylsilan
e; Triethylsilylacetyle
ne
More stable protected acetylene useful in Sonogashira reactions.
Reacts with enol silyl ethers to form ?,?-bis-trans-&beta-
triethylsilylethenyl ketones
Extensive review of silicon based cross-coupling agents: Denmark, S. E. et al. "Organic Reactions, Volume 75" Denmark, S. E. ed., John Wiley and Sons, 233, 2011
Additional Properties
Hydrolytic Sensitivity 4: no reaction with water under neutral conditions
Application
Reacts with enol silyl ethers to form ?,?-bis-trans-?-triethylsilylethenyl ketones.1 Useful in Sonogashira cross-coupling reactions w/ more stable silyl group than the trimethylsilyl group.2
Reference
1. Amemiya, R. et al. Tetrahedron Lett. 2006, 47, 1797. 2. Larson, G. L. “Silicon-Based Cross-Coupling Reagents” Gelest, Inc. 2011.
Safety
Packaging Under Nitrogen
Alkynylsilane Cross-Coupling Agent
The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile.
Ethynyltriethylsilane; Triethylsilylacetylene
More stable protected acetylene useful in Sonogashira reactions.
Reacts with enol silyl ethers to form ?,?-bis-trans-&beta-triethylsilylethenyl ketones
Extensive review of silicon based cross-coupling agents: Denmark, S. E. et al. "Organic Reactions, Volume 75" Denmark, S. E. ed., John Wiley and Sons, 233, 2011
