Gelest, Inc. DIMETHYLCHLOROSILANE, 98% SID4070.0

Additional Properties Hydrolytic Sensitivity 8: reacts rapidly with moisture, water, protic solvents Surface Tension (mN/m) 17.1 Application Review of synthetic utility.1 Enantioselectively converts ?-hydroxyketones to 1,2-diols.2 Reference 1. Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis, Fuchs, P. L. Ed., John Wiley and Sons, Ltd., 2011, p. 156-157. 2. Burk, M. J.; Feaster, J. E. Tetrahedron Lett. 1992, 33, 2099. Safety Packaging Under Nitrogen Tri-substituted Silane Reducing Agent Organosilanes are hydrocarbon-like and possess the ability to serve as both ionic and free-radical reducing agents. These reagents and their reaction by-products are safer and more easily handled and disposed than many other reducing agents. The metallic nature of silicon and its low electronegativity relative to hydrogen lead to polarization of the Si-H bond yielding a hydridic hydrogen and a milder reducing agent compared to aluminum-, boron-, and other metal-based hydrides. A summary of some key silane reductions are presented in Table 1 of the Silicon-Based Reducing Agents brochure. Dimethylchlorosilane ; Chlorodimethylsilane ; Dimethylsilyl chloride ΔHvap: 26.2 kJ/mol Surface tension: 17.1 mN/m Specific heat: 1.13 J/g/°C Thermal conductivity: 0.116 W/mK Critical temperature: 202 °C Undergoes hydrosilylation reactions Enantioselectively converts ?-hydroxyketones to 1,2-diols Will form high-boiling polymeric by-products with aqueous work-up Extensive review of silicon based reducing agents: Larson, G.; Fry, J. L. "Ionic and Organometallic-Catal yzed Organosilane Reductions", Wipf, P., Ed.; Wiley, 2007