Additional Properties
Hydrolytic Sensitivity 8: reacts rapidly with moisture, water, protic solvents Fieser F&F: Vol. 16, p 71; Vol. 17, p 75; Vol. 21, p 129. Safety
Packaging Under Nitrogen Specialty Silicon-Based Blocking Agent Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure. Chloromethyldimethyl
chlorosilane; (Chlorodimethylsilyl
)chloromethane; Chloro(chloromethyl)
dimethylsilane; CMDMCS
Can form cyclic products with appropriate 1,2-difunctional substrates
Used in analytical applications for greater ECD detectability
Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure
Gelest, Inc.
Done
Datasheet
Description
Additional Properties
Hydrolytic Sensitivity 8: reacts rapidly with moisture, water, protic solvents Fieser F&F: Vol. 16, p 71; Vol. 17, p 75; Vol. 21, p 129. Safety
Packaging Under Nitrogen Specialty Silicon-Based Blocking Agent Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure. Chloromethyldimethyl
chlorosilane; (Chlorodimethylsilyl
)chloromethane; Chloro(chloromethyl)
dimethylsilane; CMDMCS
Can form cyclic products with appropriate 1,2-difunctional substrates
Used in analytical applications for greater ECD detectability
Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure
Additional Properties
Hydrolytic Sensitivity 8: reacts rapidly with moisture, water, protic solvents Fieser F&F: Vol. 16, p 71; Vol. 17, p 75; Vol. 21, p 129. Safety
Packaging Under Nitrogen Specialty Silicon-Based Blocking Agent Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure. Chloromethyldimethyl
chlorosilane; (Chlorodimethylsilyl
)chloromethane; Chloro(chloromethyl)
dimethylsilane; CMDMCS
Can form cyclic products with appropriate 1,2-difunctional substrates
Used in analytical applications for greater ECD detectability
Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure
Additional Properties
Hydrolytic Sensitivity 8: reacts rapidly with moisture, water, protic solvents
Fieser
F&F: Vol. 16, p 71; Vol. 17, p 75; Vol. 21, p 129.
Safety
Packaging Under Nitrogen
Specialty Silicon-Based Blocking Agent
Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.
Chloromethyldimethylchlorosilane; (Chlorodimethylsilyl)chloromethane; Chloro(chloromethyl)dimethylsilane; CMDMCS
Can form cyclic products with appropriate 1,2-difunctional substrates
Used in analytical applications for greater ECD detectability
Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure
