Gelest, Inc. t-BUTYLDIMETHYLCHLOROSILANE, 2.85M in toluene, 48-52% solution SIB1935.5

Additional Properties Hydrolytic Sensitivity 7: reacts slowly with moisture/water Safety Packaging Under Nitrogen Trialkylsilyl Blocking Agent Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure. tert-Butyldimethylch lorosilane; TBS-Cl; Chlorodimethyl-t-but ylsilane; tert-Butylchlorodime thylsilane; Chloro(1,1-dimethyle thyl)dimethylsilane 2.85M in toluene Used for the protection of alcohols, amines, thiols, lactams, and carboxylic acids Clean NMR characteristics of protecting group Facile removal with flouride ion sources Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure