Fitzgerald Industries International, Inc. TSC1 antibody 70R-7807

Description
Rabbit polyclonal Human TSC1 antibody Background: TSC1 is a tumor suppressor gene encoding a protein TSC1/Hamartin of about 130 kDa. Loss of its function causes TSC (tuberous sclerosis complex) or angiomyolipoma in human and in an animal model, a TSC1 knockout mouse develops a renal tumor. TSC1/Hamartin, a product of TSC1, forms a complex with TSC2/Tuberin, a product of another tumor suppressor gene TSC2 in cytoplasm. The complex suppresses mTOR activity and regulates cellular growth and division in an insulin signaling pathway. Under the condition of proliferation stimulus, forming of the complex is inhibited, and as a result, suppression to mTOR comes off and it leads to cellular growth and division.
Description
Rabbit polyclonal Human TSC1 antibody Background: TSC1 is a tumor suppressor gene encoding a protein TSC1/Hamartin of about 130 kDa. Loss of its function causes TSC (tuberous sclerosis complex) or angiomyolipoma in human and in an animal model, a TSC1 knockout mouse develops a renal tumor. TSC1/Hamartin, a product of TSC1, forms a complex with TSC2/Tuberin, a product of another tumor suppressor gene TSC2 in cytoplasm. The complex suppresses mTOR activity and regulates cellular growth and division in an insulin signaling pathway. Under the condition of proliferation stimulus, forming of the complex is inhibited, and as a result, suppression to mTOR comes off and it leads to cellular growth and division.

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Product
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Fitzgerald Industries International, Inc.
Acton, MA, USA
TSC1 antibody
70R-7807
TSC1 antibody 70R-7807
Rabbit polyclonal Human TSC1 antibody Background: TSC1 is a tumor suppressor gene encoding a protein TSC1/Hamartin of about 130 kDa. Loss of its function causes TSC (tuberous sclerosis complex) or angiomyolipoma in human and in an animal model, a TSC1 knockout mouse develops a renal tumor. TSC1/Hamartin, a product of TSC1, forms a complex with TSC2/Tuberin, a product of another tumor suppressor gene TSC2 in cytoplasm. The complex suppresses mTOR activity and regulates cellular growth and division in an insulin signaling pathway. Under the condition of proliferation stimulus, forming of the complex is inhibited, and as a result, suppression to mTOR comes off and it leads to cellular growth and division.

Rabbit polyclonal Human TSC1 antibody
Background:
TSC1 is a tumor suppressor gene encoding a protein TSC1/Hamartin of about 130 kDa. Loss of its function causes TSC (tuberous sclerosis complex) or angiomyolipoma in human and in an animal model, a TSC1 knockout mouse develops a renal tumor. TSC1/Hamartin, a product of TSC1, forms a complex with TSC2/Tuberin, a product of another tumor suppressor gene TSC2 in cytoplasm. The complex suppresses mTOR activity and regulates cellular growth and division in an insulin signaling pathway. Under the condition of proliferation stimulus, forming of the complex is inhibited, and as a result, suppression to mTOR comes off and it leads to cellular growth and division.

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Technical Specifications

  Fitzgerald Industries International, Inc.
Product Category Biological Materials
Product Number 70R-7807
Product Name TSC1 antibody
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