Fitzgerald Industries International, Inc. Syndecan 4 antibody 70R-7798

Rabbit polyclonal Human Syndecan 4 antibody Background: Syndecan, a cell surface proteoglycan, is an integral membrane protein acting as a receptor for the extracellular matrix. The syndecan family of four transmembrane heparan sulfate proteoglycans binds a variety of soluble and insoluble extracellular effectors. Syndecan extracellular domains (ectodomains) can be shed intact by proteolytic cleavage of their core proteins, yielding soluble proteoglycans that retain the binding properties of their cell surface precursors. Syndecan 4 acts in conjunction with the a5beta1 integrin to promote the formation of actin stress fibers and focal adhesions in fibronectin-adherent cells.