Fitzgerald Industries International, Inc. PRAS40 antibody 70R-7768

Description
Rabbit polyclonal Human PRAS40 antibody Background: PRAS40 (proline-rich Akt substrate of 40 kDa) is a protein with a proline-rich domain and appears at about 40 kDa by SDS PAGE. Initially it was identified as a substrate of PKB/Akt, it was later shown that it is also phosphorylated by mTORC1 (a complex including scaffold protein which is necessary for mTOR and phosphorylation of substrate by mTOR). PRAS40 binds to raptor through the mediation of the TOS motif in its structure in the same way as p70 S6 kinase and 4EP1 do as substrates of mTOR, then PRAS40 is phosphorylated by mTORC1 at Ser183 (human), and the phosphorylated PRAS40 will be dissociated from raptor. Therefore, it is considered that PRAS40 is involved in signal transducing pathway through the mediation of not only PKB/Akt but also mTOR.
Description
Rabbit polyclonal Human PRAS40 antibody Background: PRAS40 (proline-rich Akt substrate of 40 kDa) is a protein with a proline-rich domain and appears at about 40 kDa by SDS PAGE. Initially it was identified as a substrate of PKB/Akt, it was later shown that it is also phosphorylated by mTORC1 (a complex including scaffold protein which is necessary for mTOR and phosphorylation of substrate by mTOR). PRAS40 binds to raptor through the mediation of the TOS motif in its structure in the same way as p70 S6 kinase and 4EP1 do as substrates of mTOR, then PRAS40 is phosphorylated by mTORC1 at Ser183 (human), and the phosphorylated PRAS40 will be dissociated from raptor. Therefore, it is considered that PRAS40 is involved in signal transducing pathway through the mediation of not only PKB/Akt but also mTOR.

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Fitzgerald Industries International, Inc.
Acton, MA, USA
PRAS40 antibody
70R-7768
PRAS40 antibody 70R-7768
Rabbit polyclonal Human PRAS40 antibody Background: PRAS40 (proline-rich Akt substrate of 40 kDa) is a protein with a proline-rich domain and appears at about 40 kDa by SDS PAGE. Initially it was identified as a substrate of PKB/Akt, it was later shown that it is also phosphorylated by mTORC1 (a complex including scaffold protein which is necessary for mTOR and phosphorylation of substrate by mTOR). PRAS40 binds to raptor through the mediation of the TOS motif in its structure in the same way as p70 S6 kinase and 4EP1 do as substrates of mTOR, then PRAS40 is phosphorylated by mTORC1 at Ser183 (human), and the phosphorylated PRAS40 will be dissociated from raptor. Therefore, it is considered that PRAS40 is involved in signal transducing pathway through the mediation of not only PKB/Akt but also mTOR.

Rabbit polyclonal Human PRAS40 antibody
Background:
PRAS40 (proline-rich Akt substrate of 40 kDa) is a protein with a proline-rich domain and appears at about 40 kDa by SDS PAGE. Initially it was identified as a substrate of PKB/Akt, it was later shown that it is also phosphorylated by mTORC1 (a complex including scaffold protein which is necessary for mTOR and phosphorylation of substrate by mTOR). PRAS40 binds to raptor through the mediation of the TOS motif in its structure in the same way as p70 S6 kinase and 4EP1 do as substrates of mTOR, then PRAS40 is phosphorylated by mTORC1 at Ser183 (human), and the phosphorylated PRAS40 will be dissociated from raptor. Therefore, it is considered that PRAS40 is involved in signal transducing pathway through the mediation of not only PKB/Akt but also mTOR.

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Technical Specifications

  Fitzgerald Industries International, Inc.
Product Category Biological Materials
Product Number 70R-7768
Product Name PRAS40 antibody
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